HitPredict

Interactor 1: NPM (P06748)
Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin)
Gene: NPM1

Interactor 2: RS6 (P62753)
Small ribosomal subunit protein eS6 (40S ribosomal protein S6) (Phosphoprotein NP33)
Gene: RPS6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.729

The method score is based on:

Property	Details
Experiments	29568061, 34079125, 26496610, 30021884, 36652389, 39501047
Identification Methods	proximity labelling technology, affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005730 - nucleolus GO:0005737 - cytoplasm and 7 others more... GO:0005829 - cytosol GO:0008284 - positive regulation of cell population proliferation GO:0015935 - small ribosomal subunit GO:0016020 - membrane GO:0019901 - protein kinase binding GO:0042274 - ribosomal small subunit biogenesis GO:1990904 - ribonucleoprotein complex
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1	294
Hs

1	249

Service provided by Combinatics, Japan

Last updated: 11Aug2025