HitPredict

Interactor 1: NPM (P06748)
Nucleophosmin (NPM) (Nucleolar phosphoprotein B23) (Nucleolar protein NO38) (Numatrin)
Gene: NPM1

Interactor 2: AURKB (Q96GD4)
Aurora kinase B (EC 2.7.11.1) (Aurora 1) (Aurora- and IPL1-like midbody-associated protein 1) (AIM-1) (Aurora/IPL1-related kinase 2) (ARK-2) (Aurora-related kinase 2) (STK-1) (Serine/threonine-protein kinase 12) (Serine/threonine-protein kinase 5) (Serine/threonine-protein kinase aurora-B)
Gene: AURKB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.639

Property	Details
Experiments	31586073, 24857377
Identification Methods	affinity chromatography technology, protein kinase assay, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, phosphorylation reaction, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005813 - centrosome GO:0005829 - cytosol GO:0034644 - cellular response to UV
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 294 Hs			1 344
+	Hs
		446689 NPM_HUMAN (1-294): 1.76e-143: 406: 100.00		AKT1_HUMAN (3-343): 8.07e-137: 399: 28.53
+	Hs
		169899 NPM_HUMAN (1-294): 1.76e-143: 406: 100.00		AURKA_HUMAN (1-342): 1.71e-132: 385: 58.12