HitPredict

Interactor 1: LEG1 (P09382)
Galectin-1 (Gal-1) (14 kDa laminin-binding protein) (HLBP14) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (HBL) (HPL) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (Putative MAPK-activating protein PM12) (S-Lac lectin 1)
Gene: LGALS1

Interactor 2: MPRI (P11717)
Cation-independent mannose-6-phosphate receptor (CI Man-6-P receptor) (CI-MPR) (M6PR) (300 kDa mannose 6-phosphate receptor) (MPR 300) (Insulin-like growth factor 2 receptor) (Insulin-like growth factor II receptor) (IGF-II receptor) (M6P/IGF2 receptor) (M6P/IGF2R) (CD antigen CD222)
Gene: IGF2R

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0043065 - positive regulation of apoptotic process GO:0070062 - extracellular exosome
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 135 Hs			1 2491
+	Hs
		449371 LEG1_HUMAN (1-135): 2.27e-54: 168: 100.00		MRC2_HUMAN (1813-1943): 3.47e-21: 104: 21.23
+	Hs
		572469 LEG3_HUMAN (3-134): 1.88e-49: 160: 28.47		MRC2_HUMAN (1813-1943): 3.47e-21: 104: 21.23
+	Hs
		362725 LEG1_HUMAN (1-135): 2.27e-54: 168: 100.00		FINC_HUMAN (1769-2040): 1.28e-16: 89.5: 14.63
+	Hs
		439224 LEG3_HUMAN (3-134): 1.88e-49: 160: 28.47		MMP2_HUMAN (1785-1890): 9.46e-19: 95.2: 18.18
+	Hs
		540411 LEG3_HUMAN (3-134): 1.88e-49: 160: 28.47		MMP9_HUMAN (1785-1890): 4.44e-17: 90.2: 17.27
+	Hs
		362790 LEG3_HUMAN (3-134): 1.88e-49: 160: 28.47		FINC_HUMAN (1769-2040): 1.28e-16: 89.5: 14.63
+	Hs
		121221 LEG8_HUMAN (12-134): 1.22e-36: 128: 28.13		MRC2_HUMAN (1813-1943): 3.47e-21: 104: 21.23
+	Hs
		362931 LEG7_HUMAN (1-132): 1.27e-43: 141: 33.58		FINC_HUMAN (1769-2040): 1.28e-16: 89.5: 14.63
+	Hs
		119549 LEG9_HUMAN (10-133): 2.96e-35: 126: 31.50		MRC2_HUMAN (1813-1943): 3.47e-21: 104: 21.23
+	Hs
		1107985 LEG9B_HUMAN (10-133): 1.12e-34: 124: 30.71		MRC2_HUMAN (1813-1943): 3.47e-21: 104: 21.23
+	Hs
		121099 LEG8_HUMAN (12-134): 1.22e-36: 128: 28.13		MMP9_HUMAN (1785-1890): 4.44e-17: 90.2: 17.27
+	Hs
		121070 LEG8_HUMAN (12-134): 1.22e-36: 128: 28.13		FINC_HUMAN (1769-2040): 1.28e-16: 89.5: 14.63
+	Hs
		119068 LEG9_HUMAN (10-133): 2.96e-35: 126: 31.50		FINC_HUMAN (1769-2040): 1.28e-16: 89.5: 14.63