HitPredict

Interactor 1: LEG1 (P09382)
Galectin-1 (Gal-1) (14 kDa laminin-binding protein) (HLBP14) (14 kDa lectin) (Beta-galactoside-binding lectin L-14-I) (Galaptin) (HBL) (HPL) (Lactose-binding lectin 1) (Lectin galactoside-binding soluble 1) (Putative MAPK-activating protein PM12) (S-Lac lectin 1)
Gene: LGALS1

Interactor 2: ITA4 (P13612)
Integrin alpha-4 (CD49 antigen-like family member D) (Integrin alpha-IV) (VLA-4 subunit alpha) (CD antigen CD49d)
Gene: ITGA4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	33961781, 22623428
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0070062 - extracellular exosome GO:0098609 - cell-cell adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 135 Hs			1 1032
+	Hs
		121095 LEG8_HUMAN (12-134): 1.22e-36: 128: 28.13		ITA4_HUMAN (1-1032): 0: 1246: 100.00
+	Hs
		449259 LEG1_HUMAN (1-135): 2.27e-54: 168: 100.00		ITA9_HUMAN (29-1025): 0: 1060: 41.59
+	Hs
		449225 LEG1_HUMAN (1-135): 2.27e-54: 168: 100.00		ITA8_HUMAN (1-1023): 0: 903: 24.08
+	Hs
		449190 LEG1_HUMAN (1-135): 2.27e-54: 168: 100.00		ITA6_HUMAN (14-1009): 0: 867: 24.46
+	Hs
		449257 LEG1_HUMAN (1-135): 2.27e-54: 168: 100.00		ITA7_HUMAN (1-1009): 0: 863: 24.52
+	Hs
		419138 LEG1_HUMAN (1-135): 2.27e-54: 168: 100.00		ITAV_HUMAN (31-1007): 0: 862: 25.46
+	Hs
		443022 LEG1_HUMAN (1-135): 2.27e-54: 168: 100.00		ITA5_HUMAN (33-1017): 0: 862: 24.90
+	Hs
		443032 LEG3_HUMAN (3-134): 1.88e-49: 160: 28.47		ITA5_HUMAN (33-1017): 0: 862: 24.90
+	Hs
		443090 LEG12_HUMAN (6-134): 8.15e-40: 137: 24.64		ITA5_HUMAN (33-1017): 0: 862: 24.90
+	Hs
		121078 LEG8_HUMAN (12-134): 1.22e-36: 128: 28.13		ITAV_HUMAN (31-1007): 0: 862: 25.46
+	Hs
		121084 LEG8_HUMAN (12-134): 1.22e-36: 128: 28.13		ITA5_HUMAN (33-1017): 0: 862: 24.90
+	Hs
		449196 LEG1_HUMAN (1-135): 2.27e-54: 168: 100.00		ITA3_HUMAN (1-1021): 0: 818: 22.87
+	Mm
		139224 LEG9_MOUSE (5-133): 5.75e-38: 133: 27.21		ITA2B_MOUSE (27-1012): 0: 774: 26.20
+	Hs
		449228 LEG1_HUMAN (1-135): 2.27e-54: 168: 100.00		ITA1_HUMAN (1-186): 1.04e-41: 168: 25.67
+	Hs
		572330 LEG3_HUMAN (3-134): 1.88e-49: 160: 28.47		ITA1_HUMAN (1-186): 1.04e-41: 168: 25.67
+	Hs
		449180 LEG1_HUMAN (1-135): 2.27e-54: 168: 100.00		ITA2_HUMAN (27-183): 2.04e-34: 145: 28.30
+	Hs
		566849 LEG3_HUMAN (3-134): 1.88e-49: 160: 28.47		ITA2_HUMAN (27-183): 2.04e-34: 145: 28.30
+	Hs
		506097 LEG3_HUMAN (3-134): 1.88e-49: 160: 28.47		ITAM_HUMAN (22-185): 1.4e-26: 119: 24.39
+	Hs
		121102 LEG8_HUMAN (12-134): 1.22e-36: 128: 28.13		ITA2_HUMAN (27-183): 2.04e-34: 145: 28.30
+	Hs
		121106 LEG8_HUMAN (12-134): 1.22e-36: 128: 28.13		ITAL_HUMAN (12-183): 1.18e-15: 84.4: 21.02