HitPredict

Interactor 1: PABP1 (P11940)
Polyadenylate-binding protein 1 (PABP-1) (Poly(A)-binding protein 1)
Gene: PABPC1

Interactor 2: SRSF3 (P84103)
Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3)
Gene: SRSF3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27381497
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0003723 - RNA binding GO:0005737 - cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 636 Hs			1 164
+	Hs
		516478 PABP1_HUMAN (1-636): 0: 582: 100.00		SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65
+	Hs
		266904 PABP1_HUMAN (1-636): 0: 582: 100.00		SRS10_HUMAN (1-164): 2.25e-24: 96.6: 32.54
+	Hs
		516425 PABP1_HUMAN (1-636): 0: 582: 100.00		NCBP2_HUMAN (7-117): 3.6e-25: 96.1: 24.14
+	Hs
		516495 PABP1_HUMAN (1-636): 0: 582: 100.00		PABP4_HUMAN (5-91): 1.61e-21: 91.9: 26.09
+	Hs
		516339 PABP1_HUMAN (1-636): 0: 582: 100.00		PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77
+	Hs
		516689 PABP1_HUMAN (1-636): 0: 582: 100.00		PABP3_HUMAN (1-91): 6.48e-19: 84.6: 23.71
+	Hs
		516493 PABP1_HUMAN (1-636): 0: 582: 100.00		SRSF9_HUMAN (9-82): 1.91e-19: 83.2: 40.79
+	Hs
		516674 PABP1_HUMAN (1-636): 0: 582: 100.00		RBM4_HUMAN (11-88): 3.45e-18: 81.9: 28.21
+	Mm
		665745 PABP1_MOUSE (1-636): 0: 581: 99.69		TIA1_MOUSE (5-107): 1.59e-18: 82.6: 21.70
+	Hs
		516471 PABP1_HUMAN (1-636): 0: 582: 100.00		TIAR_HUMAN (1-95): 5.6e-18: 81.1: 26.00
+	Hs
		853881 PABP4_HUMAN (1-635): 0: 534: 74.69		NCBP2_HUMAN (7-117): 3.6e-25: 96.1: 24.14
+	Sc
		376562 PABP_YEAST (2-335): 1.06e-64: 225: 26.71		PABP_YEAST (2-93): 6.85e-19: 84.2: 20.62
+	Hs
		680437 TIA1_HUMAN (4-172): 1.71e-42: 159: 28.57		SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00
+	Hs
		992875 PABP5_HUMAN (6-179): 5.04e-39: 149: 25.26		SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65
+	Hs
		267046 PABP5_HUMAN (6-179): 5.04e-39: 149: 25.26		SRS10_HUMAN (1-164): 2.25e-24: 96.6: 32.54
+	Hs
		680422 TIA1_HUMAN (4-172): 1.71e-42: 159: 28.57		TIA1_HUMAN (5-107): 1.38e-18: 83: 21.70
+	Hs
		680439 TIA1_HUMAN (4-172): 1.71e-42: 159: 28.57		TIAR_HUMAN (1-95): 5.6e-18: 81.1: 26.00
+	Hs
		516635 PABP5_HUMAN (6-179): 5.04e-39: 149: 25.26		PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77