HitPredict

Interactor 1: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: H2AZ (P0C0S5)
Histone H2A.Z (H2A/z)
Gene: H2AZ1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	29721183
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 215 Hs			1 128
+	Hs
		449762 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		H2A2B_HUMAN (5-127): 9.2e-56: 171: 59.68
+	Hs
		449745 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		H2A2A_HUMAN (5-125): 4.61e-55: 169: 62.30
+	Hs
		643395 HMGB2_HUMAN (1-187): 7e-43: 145: 82.89		H2A1J_HUMAN (5-125): 1.24e-55: 171: 61.48
+	Hs
		643357 HMGB2_HUMAN (1-187): 7e-43: 145: 82.89		H2A2A_HUMAN (5-125): 4.61e-55: 169: 62.30
+	Hs
		470005 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00
+	Hs
		996754 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		H2A2B_HUMAN (5-127): 9.2e-56: 171: 59.68
+	Hs
		996856 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		H2A1J_HUMAN (5-125): 1.24e-55: 171: 61.48
+	Hs
		996868 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		H2AJ_HUMAN (5-127): 8.35e-56: 171: 60.48
+	Hs
		996693 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		H2A2C_HUMAN (5-127): 3.47e-55: 170: 61.29
+	Hs
		391670 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		H2A1B_HUMAN (5-125): 9.18e-55: 169: 61.48
+	Hs
		470362 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		H2A1_HUMAN (5-125): 8.23e-55: 169: 61.48
+	Hs
		555429 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		H2AX_HUMAN (5-124): 1.08e-54: 169: 61.98
+	Hs
		996711 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		H2A2A_HUMAN (5-125): 4.61e-55: 169: 62.30
+	Hs
		996730 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		H2A3_HUMAN (5-125): 5.08e-55: 169: 62.30
+	Hs
		594829 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		H2A1D_HUMAN (5-125): 7.06e-55: 169: 62.30
+	Hs
		470171 HM20A_HUMAN (64-204): 9.14e-16: 76.3: 25.69		H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00
+	Hs
		391917 HM20A_HUMAN (64-204): 9.14e-16: 76.3: 25.69		H2A1B_HUMAN (5-125): 9.18e-55: 169: 61.48
+	Hs
		470568 HM20A_HUMAN (64-204): 9.14e-16: 76.3: 25.69		H2A1_HUMAN (5-125): 8.23e-55: 169: 61.48
+	Hs
		555655 HM20A_HUMAN (64-204): 9.14e-16: 76.3: 25.69		H2AX_HUMAN (5-124): 1.08e-54: 169: 61.98
+	Sc
		514225 NHP6A_YEAST (75-164): 2.33e-23: 91.4: 45.56		H2AZ_YEAST (4-126): 3.32e-39: 129: 65.91