Protein: HCK
Tyrosine-protein kinase HCK (EC 2.7.10.2) (Hematopoietic cell kinase) (Hemopoietic cell kinase) (p59-HCK/p60-HCK) (p59Hck) (p61Hck)

Gene: HCK
Organism: Homo sapiens
Interactions: 179
UniProt ID: P08631

Gene Ontology (top 5):
GO:0001784 - phosphotyrosine residue binding
GO:0002522 - leukocyte migration involved in immune response
GO:0002758 - innate immune response-activating signaling pathway
GO:0002862 - negative regulation of inflammatory response to antigenic stimulus
GO:0004713 - protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

337804

EGFR
Epidermal growth factor receptor

3

20

High-throughput

0.843

High

433530

LYN
Tyrosine-protein kinase Lyn

3

20

High-throughput

0.839

High

442864

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

20

High-throughput

0.819

High

442812

FAK1
Focal adhesion kinase 1

2

20

High-throughput

0.811

High

442813

BTK
Tyrosine-protein kinase BTK

2

19

Small-scale

0.799

High

442772

SRC
Proto-oncogene tyrosine-protein kinase Src

2

20

Small-scale

0.789

High

145968

SH2B2
SH2B adapter protein 2

2

19

High-throughput

0.783

High

442840

PKHG4
Puratrophin-1

2

15

High-throughput

0.783

High

442779

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

20

High-throughput

0.778

High

442817

ACK1
Activated CDC42 kinase 1

2

20

Small-scale

0.778

High

442869

SH3K1
SH3 domain-containing kinase-binding protein 1

2

20

Small-scale

0.776

High

442816

SOS1
Son of sevenless homolog 1

2

20

Small-scale

0.768

High

442894

ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

2

15

Small-scale

0.768

High

442854

NGEF
Ephexin-1

2

18

High-throughput

0.767

High

269514

SKAP2
Src kinase-associated phosphoprotein 2

2

20

Small-scale

0.757

High

337315

ABL1
Tyrosine-protein kinase ABL1

2

18

Small-scale

0.754

High

442768

BCR
Breakpoint cluster region protein

2

20

Small-scale

0.754

High

175811

P73
Tumor protein p73

1

5

Small-scale

0.747

High

442822

PAK2
Serine/threonine-protein kinase PAK 2

1

18

Small-scale

0.747

High

442828

GRB14
Growth factor receptor-bound protein 14

2

20

High-throughput

0.743

High

442795

CDK9
Cyclin-dependent kinase 9

2

19

High-throughput

0.737

High

442777

RASA1
Ras GTPase-activating protein 1

1

20

Small-scale

0.724

High

442830

RASA3
Ras GTPase-activating protein 3

1

20

Small-scale

0.724

High

442875

CSF3R
Granulocyte colony-stimulating factor receptor

1

13

Small-scale

0.724

High

442815

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

5

20

Small-scale

0.713

High

442780

CBL
E3 ubiquitin-protein ligase CBL

4

20

Small-scale

0.698

High

442789

ABL2
Tyrosine-protein kinase ABL2

1

19

High-throughput

0.698

High

442897

M4K5
Mitogen-activated protein kinase kinase kinase kinase 5

1

20

High-throughput

0.698

High

441403

MET
Hepatocyte growth factor receptor

1

20

High-throughput

0.692

High

442765

KIT
Mast/stem cell growth factor receptor Kit

1

20

High-throughput

0.692

High

442825

GAB1
GRB2-associated-binding protein 1

1

20

High-throughput

0.692

High

159139

CSKP
Peripheral plasma membrane protein CASK

1

20

High-throughput

0.691

High

197879

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

3

High-throughput

0.691

High

411559

LCK
Tyrosine-protein kinase Lck

1

19

High-throughput

0.691

High

442880

STK33
Serine/threonine-protein kinase 33

1

12

High-throughput

0.691

High

431445

HS90A
Heat shock protein HSP 90-alpha

4

20

High-throughput

0.683

High

437817

HS90B
Heat shock protein HSP 90-beta

4

20

High-throughput

0.683

High

442838

CDC37
Hsp90 co-chaperone Cdc37

4

13

Small-scale

0.683

High

442824

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

3

20

Small-scale

0.680

High

442803

KR109
Keratin-associated protein 10-9

3

9

High-throughput

0.675

High

442843

MTUS2
Microtubule-associated tumor suppressor candidate 2

3

16

High-throughput

0.675

High

442846

K1C40
Keratin, type I cytoskeletal 40

3

9

High-throughput

0.675

High

442887

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

3

12

High-throughput

0.675

High

383547

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.647

High

442788

STAT3
Signal transducer and activator of transcription 3

1

15

Small-scale

0.647

High

442799

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

20

Small-scale

0.647

High

442833

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

20

High-throughput

0.647

High

442853

ABI1
Abl interactor 1

1

20

Small-scale

0.647

High

442876

DOK1
Docking protein 1

1

20

Small-scale

0.647

High

442791

WASP
Actin nucleation-promoting factor WAS

2

20

Small-scale

0.639

High

442861

PDC6I
Programmed cell death 6-interacting protein

2

16

Small-scale

0.636

High

207290

FRS3
Fibroblast growth factor receptor substrate 3

2

20

High-throughput

0.628

High

442858

OLIG1
Oligodendrocyte transcription factor 1

2

1

High-throughput

0.628

High

129173

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

Small-scale

0.618

High

442759

HCK
Tyrosine-protein kinase HCK

1

19

High-throughput

0.618

High

442782

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

20

Small-scale

0.618

High

442785

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

20

Small-scale

0.618

High

442787

IL6RB
Interleukin-6 receptor subunit beta

1

14

Small-scale

0.618

High

442794

DYN2
Dynamin-2

1

11

Small-scale

0.618

High

442821

LCP2
Lymphocyte cytosolic protein 2

1

20

Small-scale

0.618

High

442867

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

20

Small-scale

0.618

High

442889

ANLN
Anillin

1

5

High-throughput

0.618

High

442898

CD2AP
CD2-associated protein

1

20

Small-scale

0.618

High

61846

CC88B
Coiled-coil domain-containing protein 88B

2

10

High-throughput

0.606

High

252955

HSF2B
Heat shock factor 2-binding protein

2

1

High-throughput

0.606

High

280510

KRT34
Keratin, type I cuticular Ha4

2

9

High-throughput

0.606

High

280771

KRT36
Keratin, type I cuticular Ha6

2

8

High-throughput

0.606

High

329262

AGR2
Anterior gradient protein 2 homolog

2

1

High-throughput

0.606

High

442773

TRI27
Zinc finger protein RFP

2

8

High-throughput

0.606

High

442801

KR107
Keratin-associated protein 10-7

2

16

High-throughput

0.606

High

442802

KR108
Keratin-associated protein 10-8

2

7

High-throughput

0.606

High

442814

KRA11
Keratin-associated protein 1-1

2

6

High-throughput

0.606

High

442835

K1H1
Keratin, type I cuticular Ha1

2

10

High-throughput

0.606

High

442837

TRIP6
Thyroid receptor-interacting protein 6

2

20

High-throughput

0.606

High

442845

FHL5
Four and a half LIM domains protein 5

2

20

High-throughput

0.606

High

442852

KRA13
Keratin-associated protein 1-3

2

4

High-throughput

0.606

High

442856

ZSCA4
Zinc finger and SCAN domain-containing protein 4

2

1

High-throughput

0.606

High

442865

KRT35
Keratin, type I cuticular Ha5

2

10

High-throughput

0.606

High

442873

TOX2
TOX high mobility group box family member 2

2

4

High-throughput

0.606

High

442893

TRIM1
Probable E3 ubiquitin-protein ligase MID2

2

14

High-throughput

0.606

High

442778

MK
Midkine

2

0

High-throughput

0.580

High

442818

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

442862

TEKT4
Tektin-4

2

0

High-throughput

0.580

High

442868

RBPMS
RNA-binding protein with multiple splicing

2

0

High-throughput

0.580

High

442872

AP4AT
AP-4 complex accessory subunit Tepsin

2

0

High-throughput

0.580

High

442879

KRA31
Keratin-associated protein 3-1

2

0

High-throughput

0.580

High

442888

BPIA1
BPI fold-containing family A member 1

2

0

High-throughput

0.580

High

442850

NT2NA
Notch homolog 2 N-terminal-like protein A

2

9

High-throughput

0.578

High

442826

RPGF1
Rap guanine nucleotide exchange factor 1

1

14

Small-scale

0.573

High

180198

MAGB2
Melanoma-associated antigen B2

2

2

High-throughput

0.571

High

225830

KPRB
Phosphoribosyl pyrophosphate synthase-associated protein 2

2

10

High-throughput

0.571

High

241257

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

2

12

High-throughput

0.571

High

323553

BAG2
BAG family molecular chaperone regulator 2

2

3

High-throughput

0.571

High

388165

HSPB1
Heat shock protein beta-1

2

6

High-throughput

0.571

High

432510

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

2

13

High-throughput

0.571

High

442766

BIP
Endoplasmic reticulum chaperone BiP

2

17

High-throughput

0.571

High

442767

HSP7C
Heat shock cognate 71 kDa protein

2

11

High-throughput

0.571

High

442769

PRPS2
Ribose-phosphate pyrophosphokinase 2

2

10

High-throughput

0.571

High

442775

HSP76
Heat shock 70 kDa protein 6

2

11

High-throughput

0.571

High

442783

RL22
Large ribosomal subunit protein eL22

2

1

High-throughput

0.571

High

442786

GRP75
Stress-70 protein, mitochondrial

2

20

High-throughput

0.571

High

442796

FXR1
RNA-binding protein FXR1

2

5

High-throughput

0.571

High

442805

PRPS1
Ribose-phosphate pyrophosphokinase 1

2

10

High-throughput

0.571

High

442806

RL37
Large ribosomal subunit protein eL37

2

1

High-throughput

0.571

High

442810

AKA12
A-kinase anchor protein 12

2

10

High-throughput

0.571

High

442819

CHD3
Chromodomain-helicase-DNA-binding protein 3

2

6

High-throughput

0.571

High

442829

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

2

10

High-throughput

0.571

High

442831

CHD4
Chromodomain-helicase-DNA-binding protein 4

2

6

High-throughput

0.571

High

442834

RBP1
RalA-binding protein 1

2

20

High-throughput

0.571

High

442859

CHD5
Chromodomain-helicase-DNA-binding protein 5

2

6

High-throughput

0.571

High

442899

NS1BP
Influenza virus NS1A-binding protein

2

1

High-throughput

0.571

High

442863

ELMO1
Engulfment and cell motility protein 1

1

0

Small-scale

0.554

High

66956

CRTP1
Cysteine-rich tail protein 1

2

1

High-throughput

0.553

High

442808

CTG1B
Cancer/testis antigen 1

2

1

High-throughput

0.553

High

442820

MKRN3
Probable E3 ubiquitin-protein ligase makorin-3

2

1

High-throughput

0.553

High

442857

PNMA1
Paraneoplastic antigen Ma1

2

4

High-throughput

0.553

High

442847

LTMD1
LETM1 domain-containing protein 1

2

0

High-throughput

0.551

High

442770

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

2

0

High-throughput

0.547

High

442790

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

2

0

High-throughput

0.547

High

442891

DPP2
Dipeptidyl peptidase 2

2

0

High-throughput

0.547

High

197581

ADA12
Disintegrin and metalloproteinase domain-containing protein 12

1

20

Small-scale

0.536

High

442764

ANDR
Androgen receptor

1

20

High-throughput

0.536

High

442784

SPR2A
Small proline-rich protein 2A

1

6

Small-scale

0.536

High

442881

TMG4
Transmembrane gamma-carboxyglutamic acid protein 4

1

6

Small-scale

0.536

High

442851

ADCK2
Uncharacterized aarF domain-containing protein kinase 2

1

1

High-throughput

0.536

High

206677

WIPF1
WAS/WASL-interacting protein family member 1

1

20

Small-scale

0.527

High

442792

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

12

Small-scale

0.527

High

327157

TXD12
Thioredoxin domain-containing protein 12

2

1

High-throughput

0.521

High

442870

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

2

2

High-throughput

0.521

High

442761

WNT2
Protein Wnt-2

1

0

High-throughput

0.518

High

442874

RUFY1
RUN and FYVE domain-containing protein 1

1

14

Small-scale

0.515

High

442883

MED28
Mediator of RNA polymerase II transcription subunit 28

1

8

Small-scale

0.515

High

442827

FHL2
Four and a half LIM domains protein 2

1

20

High-throughput

0.508

High

442800

NAL12
NACHT, LRR and PYD domains-containing protein 12

1

1

Small-scale

0.506

High

393966

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.501

High

442762

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

1

6

Small-scale

0.501

High

442781

RL10
Large ribosomal subunit protein uL16

1

4

Small-scale

0.501

High

442823

U119A
Protein unc-119 homolog A

1

4

Small-scale

0.501

High

442866

CBP
CREB-binding protein

1

15

Small-scale

0.501

High

442882

ADA19
Disintegrin and metalloproteinase domain-containing protein 19

1

20

Small-scale

0.501

High

442890

ADA22
Disintegrin and metalloproteinase domain-containing protein 22

1

20

Small-scale

0.501

High

281509

WFS1
Wolframin

1

0

High-throughput

0.493

High

359584

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

9

High-throughput

0.481

High

152233

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

20

Small-scale

0.479

High

302807

HEXI1
Protein HEXIM1

1

6

High-throughput

0.479

High

442760

LEG1
Galectin-1

1

1

High-throughput

0.479

High

442771

FCGR1
High affinity immunoglobulin gamma Fc receptor I

1

20

Small-scale

0.479

High

442774

PECA1
Platelet endothelial cell adhesion molecule

1

16

Small-scale

0.479

High

442776

NUCL
Nucleolin

1

3

Small-scale

0.479

High

442793

PAXI
Paxillin

1

20

High-throughput

0.479

High

442797

CCR3
C-C chemokine receptor type 3

1

6

Small-scale

0.479

High

442798

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

5

High-throughput

0.479

High

442804

ACTB
Actin, cytoplasmic 1

1

5

Small-scale

0.479

High

442807

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

11

Small-scale

0.479

High

442811

UPAR
Urokinase plasminogen activator surface receptor

1

2

Small-scale

0.479

High

442832

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.479

High

442836

SF3B3
Splicing factor 3B subunit 3

1

2

Small-scale

0.479

High

442839

LARP7
La-related protein 7

1

12

High-throughput

0.479

High

442885

TRPV4
Transient receptor potential cation channel subfamily V member 4

1

11

Small-scale

0.479

High

442886

GPVI
Platelet glycoprotein VI

1

14

Small-scale

0.479

High

442892

EVL
Ena/VASP-like protein

1

17

Small-scale

0.479

High

442896

3BP1
SH3 domain-binding protein 1

1

20

Small-scale

0.479

High

442763

NT2NC
Notch homolog 2 N-terminal-like protein C

1

9

High-throughput

0.470

High

442877

TS101
Tumor susceptibility gene 101 protein

1

0

Small-scale

0.458

High

442878

CNPY3
Protein canopy homolog 3

1

0

Small-scale

0.458

High

237552

DIAP1
Protein diaphanous homolog 1

1

9

Small-scale

0.445

High

442841

H90B3
Putative heat shock protein HSP 90-beta-3

1

20

High-throughput

0.445

High

442842

H90B2
Putative heat shock protein HSP 90-beta 2

1

20

High-throughput

0.445

High

442855

CD177
CD177 antigen

1

1

Small-scale

0.445

High

463

NBPFJ
Neuroblastoma breakpoint family member 19

1

1

High-throughput

0.439

High

442884

WDCP
WD repeat and coiled-coil-containing protein

1

1

Small-scale

0.437

High

442809

MDM2
E3 ubiquitin-protein ligase Mdm2

1

5

Small-scale

0.408

High

442844

KPRP
Keratinocyte proline-rich protein

2

0

High-throughput

0.316

High

442860

NEUFC
Neuferricin

2

0

High-throughput

0.316

High

442871

CA074
UPF0739 protein C1orf74

1

0

High-throughput

0.279

Low

442895

RT02
Small ribosomal subunit protein uS2m

1

0

High-throughput

0.279

Low

442849

CHSTF
Carbohydrate sulfotransferase 15

1

0

Small-scale

0.249

Low

442848

Q75KN0
Uncharacterized protein FLJ10842

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024