HitPredict

Interactor 1: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: CDK2 (P24941)
Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)
Gene: CDK2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	21319273
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000793 - condensed chromosome GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005768 - endosome
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 215 Hs			1 298
+	Hs
		625125 HMGB2_HUMAN (1-187): 7e-43: 145: 82.89		CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00
+	Hs
		414690 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90
+	Hs
		414748 HMGB2_HUMAN (1-187): 7e-43: 145: 82.89		CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90
+	Hs
		643326 HMGB2_HUMAN (1-187): 7e-43: 145: 82.89		CDK5_HUMAN (1-292): 1.62e-138: 394: 59.39
+	Hs
		567641 UBF1_HUMAN (49-205): 2.54e-09: 58.2: 20.00		CDK2_HUMAN (1-298): 8.79e-167: 466: 100.00
+	Hs
		414816 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90
+	Hs
		415030 CIC_HUMAN (3-96): 2.76e-12: 67: 22.34		CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90
+	Hs
		841179 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		CDK7_HUMAN (2-298): 9.81e-124: 359: 44.00
+	Hs
		414863 TFAM_HUMAN (95-186): 2.95e-09: 57.1: 17.39		CDK1_HUMAN (1-289): 7.44e-144: 408: 66.90