HitPredict

Interactor 1: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: H4 (P62805)
Histone H4
Gene: H4C1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	30804502, 29721183
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005576 - extracellular region GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 215 Hs			1 103
+	Hs
		643301 HMGB2_HUMAN (1-187): 7e-43: 145: 82.89		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		175766 HMGB3_HUMAN (13-181): 1.02e-42: 144: 71.60		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917167 SSRP1_HUMAN (53-164): 1.59e-28: 114: 37.50		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		297483 TOX4_HUMAN (91-163): 1.19e-27: 111: 38.36		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Ce
		136663 SSP1B_CAEEL (91-208): 5.6e-18: 83.7: 32.80		H4_CAEEL (1-103): 1.41e-48: 151: 99.03
+	Hs
		917971 HM20A_HUMAN (64-204): 9.14e-16: 76.3: 25.69		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		918056 HM20B_HUMAN (64-165): 1.22e-15: 76: 32.35		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Sc
		356198 NHP6A_YEAST (75-164): 2.33e-23: 91.4: 45.56		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Sc
		356199 NHP6B_YEAST (73-164): 1.14e-21: 87.1: 42.39		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Hs
		917780 CIC_HUMAN (3-96): 2.76e-12: 67: 22.34		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Sc
		356373 IXR1_YEAST (79-174): 6.78e-16: 77.4: 23.96		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Hs
		567667 UBF1_HUMAN (49-205): 2.54e-09: 58.2: 20.00		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917116 TFAM_HUMAN (95-186): 2.95e-09: 57.1: 17.39		H4_HUMAN (1-103): 1.38e-48: 151: 100.00