HitPredict

Interactor 1: HMGB1 (P09429)
High mobility group protein B1 (High mobility group protein 1) (HMG-1)
Gene: HMGB1

Interactor 2: LHX4 (Q969G2)
LIM/homeobox protein Lhx4 (LIM homeobox protein 4)
Gene: LHX4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006357 - regulation of transcription by RNA polymerase II GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 215 Hs			1 390
+	Hs
		643381 HMGB2_HUMAN (1-187): 7e-43: 145: 82.89		LHX4_HUMAN (1-390): 1.1e-107: 323: 100.00
+	Hs
		1281169 CIC_HUMAN (3-96): 2.76e-12: 67: 22.34		LHX4_HUMAN (1-390): 1.1e-107: 323: 100.00
+	Hs
		1300973 CIC_HUMAN (3-96): 2.76e-12: 67: 22.34		LHX3_HUMAN (1-390): 1.94e-87: 271: 60.25
+	Hs
		449608 HMGB1_HUMAN (1-174): 9.92e-46: 152: 100.00		LHX2_HUMAN (8-361): 5.19e-45: 162: 21.99
+	Hs
		175759 HMGB3_HUMAN (13-181): 1.02e-42: 144: 71.60		LHX2_HUMAN (8-361): 5.19e-45: 162: 21.99
+	Dm
		1098042 DICH_DROME (7-101): 3.34e-27: 108: 24.21		Q9V472_DROME (11-357): 1.22e-51: 181: 22.93
+	Hs
		238117 CIC_HUMAN (3-96): 2.76e-12: 67: 22.34		LMX1B_HUMAN (10-347): 2.11e-62: 207: 28.00
+	Hs
		818192 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		PRIC2_HUMAN (2-367): 1.17e-46: 172: 16.67
+	Hs
		818332 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		ISL2_HUMAN (21-319): 1.05e-47: 167: 28.02
+	Ce
		447557 EGL13_CAEEL (4-96): 1.53e-24: 102: 19.36		MEC3_CAEEL (2-246): 3.67e-47: 165: 25.16
+	Hs
		881817 SOX10_HUMAN (4-98): 1.86e-21: 93.2: 14.74		LMO3_HUMAN (19-158): 3.93e-52: 172: 37.67
+	Hs
		818493 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		LHX9_HUMAN (19-348): 1.54e-45: 163: 23.30
+	Dm
		102044 G2J5V9_DROME (95-164): 2.96e-15: 71.7: 35.21		AWH_DROME (24-279): 5.64e-49: 168: 32.85
+	Dm
		1215217 Q9VCZ4_DROME (95-164): 1.78e-13: 66.7: 35.21		AWH_DROME (24-279): 5.64e-49: 168: 32.85
+	Hs
		1301002 CIC_HUMAN (3-96): 2.76e-12: 67: 22.34		LHX6_HUMAN (8-290): 1.23e-46: 165: 27.78
+	Hs
		839810 CIC_HUMAN (3-96): 2.76e-12: 67: 22.34		LHX2_HUMAN (8-361): 5.19e-45: 162: 21.99
+	Hs
		300992 SOX2_HUMAN (3-94): 2.8e-25: 102: 23.91		ABLM3_HUMAN (30-193): 1.92e-23: 104: 21.77
+	Ce
		590592 SEM2_CAEEL (61-161): 2.83e-29: 114: 20.79		HM14_CAEEL (88-390): 1.5e-13: 73.1: 10.79
+	Ce
		590589 EGL13_CAEEL (4-96): 1.53e-24: 102: 19.36		HM14_CAEEL (88-390): 1.5e-13: 73.1: 10.79
+	Hs
		638579 HM20A_HUMAN (64-204): 9.14e-16: 76.3: 25.69		RBTN1_HUMAN (89-189): 8.78e-11: 61.9: 16.83