HitPredict - High confidence protein-protein interactions

Interactor 1: ACHA4 (P09483)
Neuronal acetylcholine receptor subunit alpha-4
Gene: Chrna4

Interactor 2: ACHB4 (P12392)
Neuronal acetylcholine receptor subunit beta-4 (Neuronal acetylcholine receptor non-alpha-2 chain) (N-alpha 2)
Gene: Chrnb4

Species: Rattus norvegicus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	20566638
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Neur_chan_LBD~Neur_chan_LBD, Neur_chan_LBD~Neur_chan_memb, Neur_chan_memb~Neur_chan_memb
Common GO terms	GO:0005886 - plasma membrane GO:0005892 - acetylcholine-gated channel complex GO:0007165 - signal transduction GO:0007626 - locomotory behavior GO:0015464 - acetylcholine receptor activity and 15 others more... GO:0019228 - neuronal action potential GO:0022848 - acetylcholine-gated monoatomic cation-selective channel activity GO:0032991 - protein-containing complex GO:0035094 - response to nicotine GO:0035095 - behavioral response to nicotine GO:0042166 - acetylcholine binding GO:0042391 - regulation of membrane potential GO:0043005 - neuron projection GO:0044877 - protein-containing complex binding GO:0045202 - synapse GO:0051899 - membrane depolarization GO:0095500 - acetylcholine receptor signaling pathway GO:0098981 - cholinergic synapse GO:1901363 - heterocyclic compound binding GO:1904315 - transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1	630
Rn

1	495

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024