Protein: MDHC
Malate dehydrogenase, cytoplasmic (EC 1.1.1.37) (Aromatic alpha-keto acid reductase) (KAR) (EC 1.1.1.96) (Cytosolic malate dehydrogenase)

Gene: MDHC, MDH1
Organism: Homo sapiens
Interactions: 110
UniProt ID: P40925

Gene Ontology (top 5):
GO:0004470 - malic enzyme activity
GO:0005615 - extracellular space
GO:0005737 - cytoplasm
GO:0005813 - centrosome
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

828626

MDHC
Malate dehydrogenase, cytoplasmic

2

14

Small-scale

0.768

High

240966

PRKN
E3 ubiquitin-protein ligase parkin

3

14

Small-scale

0.640

High

358632

LDHA
L-lactate dehydrogenase A chain

1

15

High-throughput

0.618

High

362905

EGFR
Epidermal growth factor receptor

2

4

Small-scale

0.608

High

410681

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

1

High-throughput

0.576

High

828633

TERF1
Telomeric repeat-binding factor 1

1

2

High-throughput

0.573

High

828634

TERA
Transitional endoplasmic reticulum ATPase

2

8

High-throughput

0.571

High

828658

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

8

High-throughput

0.571

High

413334

P53
Cellular tumor antigen p53

1

3

Small-scale

0.561

High

828632

TTC3
E3 ubiquitin-protein ligase TTC3

1

5

High-throughput

0.541

High

180737

TIF1A
Transcription intermediary factor 1-alpha

1

9

High-throughput

0.536

High

213847

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

1

High-throughput

0.536

High

385520

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

5

High-throughput

0.536

High

468143

HS90B
Heat shock protein HSP 90-beta

1

10

Small-scale

0.536

High

529259

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.536

High

828645

KPCZ
Protein kinase C zeta type

1

4

High-throughput

0.536

High

828655

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

1

High-throughput

0.536

High

828665

MYLK4
Myosin light chain kinase family member 4

1

7

High-throughput

0.536

High

828675

KPCD2
Serine/threonine-protein kinase D2

1

5

High-throughput

0.536

High

828690

SAR1B
Small COPII coat GTPase SAR1B

1

5

High-throughput

0.536

High

828685

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.529

High

683397

IKBA
NF-kappa-B inhibitor alpha

1

4

High-throughput

0.515

High

187306

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

0

High-throughput

0.513

High

828656

HSPB2
Heat shock protein beta-2

1

4

High-throughput

0.508

High

828627

MAOX
NADP-dependent malic enzyme

1

2

Small-scale

0.505

High

828636

CDC42
Cell division control protein 42 homolog

1

2

High-throughput

0.501

High

828647

MPP3
MAGUK p55 subfamily member 3

1

2

High-throughput

0.494

High

634334

LMNB1
Lamin-B1

1

6

High-throughput

0.489

High

547102

PYC
Pyruvate carboxylase, mitochondrial

1

2

Small-scale

0.484

High

828671

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

3

Small-scale

0.481

High

65522

DDTL
D-dopachrome decarboxylase-like protein

1

1

High-throughput

0.479

High

169990

AURKA
Aurora kinase A

1

3

High-throughput

0.479

High

176947

CE290
Centrosomal protein of 290 kDa

1

10

High-throughput

0.479

High

353061

AGR2
Anterior gradient protein 2 homolog

1

3

High-throughput

0.479

High

365747

KAD1
Adenylate kinase isoenzyme 1

1

3

High-throughput

0.479

High

400418

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.479

High

461233

HS90A
Heat shock protein HSP 90-alpha

1

10

Small-scale

0.479

High

606361

CEBPB
CCAAT/enhancer-binding protein beta

1

8

High-throughput

0.479

High

713913

PML
Protein PML

1

9

High-throughput

0.479

High

728079

AKT1
RAC-alpha serine/threonine-protein kinase

1

2

Small-scale

0.479

High

772104

MSX2
Homeobox protein MSX-2

1

2

High-throughput

0.479

High

798793

BRCA1
Breast cancer type 1 susceptibility protein

1

9

High-throughput

0.479

High

828628

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.479

High

828629

SYAC
Alanine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.479

High

828630

GSK3B
Glycogen synthase kinase-3 beta

1

7

High-throughput

0.479

High

828631

GDIR1
Rho GDP-dissociation inhibitor 1

1

1

High-throughput

0.479

High

828635

MTPN
Myotrophin

1

4

High-throughput

0.479

High

828637

UBC12
NEDD8-conjugating enzyme Ubc12

1

3

High-throughput

0.479

High

828639

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

828641

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

6

Small-scale

0.479

High

828642

CYC
Cytochrome c

1

1

High-throughput

0.479

High

828643

HSF1
Heat shock factor protein 1

1

4

High-throughput

0.479

High

828648

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

828651

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

3

High-throughput

0.479

High

828653

EMC2
ER membrane protein complex subunit 2

1

2

High-throughput

0.479

High

828654

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

828657

IF44L
Interferon-induced protein 44-like

1

2

High-throughput

0.479

High

828659

TET5C
Terminal nucleotidyltransferase 5C

1

2

High-throughput

0.479

High

828662

ANR12
Ankyrin repeat domain-containing protein 12

1

2

High-throughput

0.479

High

828663

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.479

High

828669

ALMS1
Centrosome-associated protein ALMS1

1

2

High-throughput

0.479

High

828670

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

6

High-throughput

0.479

High

828672

ANM1
Protein arginine N-methyltransferase 1

1

7

High-throughput

0.479

High

828673

BAG1
BAG family molecular chaperone regulator 1

1

3

High-throughput

0.479

High

828674

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

8

High-throughput

0.479

High

828677

ZN106
Zinc finger protein 106

1

4

High-throughput

0.479

High

828678

PKHA4
Pleckstrin homology domain-containing family A member 4

1

10

High-throughput

0.479

High

828680

NMRL1
NmrA-like family domain-containing protein 1

1

3

High-throughput

0.479

High

828682

ACO13
Acyl-coenzyme A thioesterase 13

1

1

High-throughput

0.479

High

828684

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.479

High

828686

PD1L1
Programmed cell death 1 ligand 1

1

2

High-throughput

0.479

High

828687

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

787616

SPB5
Serpin B5

1

0

Small-scale

0.460

High

276758

TBCA
Tubulin-specific chaperone A

1

0

High-throughput

0.458

High

370166

CYTN
Cystatin-SN

1

0

Small-scale

0.458

High

402753

CYTB
Cystatin-B

1

0

High-throughput

0.458

High

762267

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

0

High-throughput

0.458

High

828640

RS28
Small ribosomal subunit protein eS28

1

0

High-throughput

0.458

High

828649

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.458

High

828668

DDX55
ATP-dependent RNA helicase DDX55

1

0

High-throughput

0.458

High

563358

CFTR
Cystic fibrosis transmembrane conductance regulator

1

5

High-throughput

0.445

High

765204

BMI1
Polycomb complex protein BMI-1

1

11

High-throughput

0.445

High

828638

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

3

High-throughput

0.445

High

828660

A16L1
Autophagy-related protein 16-1

1

6

High-throughput

0.445

High

828661

PKHA7
Pleckstrin homology domain-containing family A member 7

1

12

High-throughput

0.445

High

828676

ATG5
Autophagy protein 5

1

1

High-throughput

0.445

High

774896

FUS
RNA-binding protein FUS

1

4

High-throughput

0.439

High

105491

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

239764

PCDH7
Protocadherin-7

1

2

High-throughput

0.437

High

259563

BRD4
Bromodomain-containing protein 4

1

4

High-throughput

0.437

High

411506

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.437

High

588094

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.437

High

694809

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

767586

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

828644

LMNB2
Lamin-B2

1

5

High-throughput

0.437

High

828646

TADBP
TAR DNA-binding protein 43

1

9

Small-scale

0.437

High

828652

RBM39
RNA-binding protein 39

1

4

High-throughput

0.437

High

828666

EMC5
ER membrane protein complex subunit 5

1

1

High-throughput

0.437

High

828667

EMC1
ER membrane protein complex subunit 1

1

2

High-throughput

0.437

High

828683

SLX9
Ribosome biogenesis protein SLX9 homolog

1

1

High-throughput

0.437

High

828689

AAR2
Protein AAR2 homolog

1

3

High-throughput

0.437

High

828650

DAG1
Dystroglycan 1

1

0

Small-scale

0.426

High

116511

H7C1K6
Interferon induced protein 44 like

1

2

High-throughput

0.407

High

429447

JUN
Transcription factor Jun

1

10

High-throughput

0.407

High

828664

CSMD2
CUB and sushi domain-containing protein 2

2

0

High-throughput

0.313

High

466844

ACM2
Muscarinic acetylcholine receptor M2

1

0

High-throughput

0.282

High

828681

LT4R2
Leukotriene B4 receptor 2

1

0

High-throughput

0.282

High

828679

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.279

Low

828688

FA50B
Protein FAM50B

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025