HitPredict

Interactor 1: TPM1 (P09493)
Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1)
Gene: TPM1

Interactor 2: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35063084
Identification Methods	proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003779 - actin binding GO:0005829 - cytosol GO:0034614 - cellular response to reactive oxygen species
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 284 Hs			1 758
+	Hs
		418857 TPM3_HUMAN (1-284): 1.02e-43: 152: 91.20		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		434331 TPM2_HUMAN (1-284): 1.39e-38: 138: 85.56		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		496812 TPM4_HUMAN (42-284): 3.76e-33: 123: 68.72		TAU_HUMAN (1-758): 3.6e-89: 298: 100.00
+	Hs
		451255 TPM1_HUMAN (1-284): 2.35e-44: 153: 100.00		MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57
+	Hs
		418956 TPM3_HUMAN (1-284): 1.02e-43: 152: 91.20		MDC1_HUMAN (2-755): 3.72e-28: 124: 8.57