HitPredict

Interactor 1: PUTA (P09546)
Bifunctional protein PutA [Includes: Proline dehydrogenase (EC 1.5.5.2) (Proline oxidase); Delta-1-pyrroline-5-carboxylate dehydrogenase (P5C dehydrogenase) (EC 1.2.1.88) (L-glutamate gamma-semialdehyde dehydrogenase)]
Gene: PUTA

Interactor 2: PUTA (P09546)
Bifunctional protein PutA [Includes: Proline dehydrogenase (EC 1.5.5.2) (Proline oxidase); Delta-1-pyrroline-5-carboxylate dehydrogenase (P5C dehydrogenase) (EC 1.2.1.88) (L-glutamate gamma-semialdehyde dehydrogenase)]
Gene: PUTA

Species: Escherichia coli K-12

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.866

The method score is based on:

Property Details
Experiments 12009917, 12514740, 1618807
Identification Methods molecular sieving, x-ray crystallography, dynamic light scattering, cosedimentation through density gradient
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Aldedh~Aldedh, Aldedh~Pro_dh, Aldedh~Pro_dh-DNA_bdg, Pro_dh~Pro_dh, Pro_dh~Pro_dh-DNA_bdg, Pro_dh~PRODH
Common GO terms GO:0000987 - cis-regulatory region sequence-specific DNA binding
GO:0001217 - DNA-binding transcription repressor activity
GO:0003677 - DNA binding
GO:0003842 - 1-pyrroline-5-carboxylate dehydrogenase activity
GO:0004657 - proline dehydrogenase activity
and 10 others

more...
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 1320
Ec

1 1320
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Dr
+ Sc
+ Sc
+ Sc
+ Sc
+ Ec

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Last updated: 15 Jul 2024