Protein: SRP54
Signal recognition particle subunit SRP54 (EC 3.6.5.4) (Signal recognition particle 54 kDa protein)

Gene: SRP54
Organism: Homo sapiens
Interactions: 139
UniProt ID: P61011

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

956198

SRP68
Signal recognition particle subunit SRP68

5

2

Small-scale

0.927

High

884015

SRP09
Signal recognition particle 9 kDa protein

5

1

Small-scale

0.716

High

956128

SRP54
Signal recognition particle subunit SRP54

1

11

Small-scale

0.710

High

469046

SRPRA
Signal recognition particle receptor subunit alpha

1

11

Small-scale

0.692

High

479363

SRP19
Signal recognition particle 19 kDa protein

1

3

High-throughput

0.691

High

956208

SRPRB
Signal recognition particle receptor subunit beta

1

7

High-throughput

0.691

High

303477

SRP72
Signal recognition particle subunit SRP72

2

3

High-throughput

0.628

High

536866

HSP7C
Heat shock cognate 71 kDa protein

2

1

High-throughput

0.628

High

788612

SRP14
Signal recognition particle 14 kDa protein

3

0

Small-scale

0.622

High

956171

GIMA8
GTPase IMAP family member 8

2

0

High-throughput

0.602

High

191578

MAGB2
Melanoma-associated antigen B2

2

1

High-throughput

0.601

High

956132

RL23A
Large ribosomal subunit protein uL23

1

0

High-throughput

0.586

High

241256

PRKN
E3 ubiquitin-protein ligase parkin

2

3

High-throughput

0.584

High

956176

LRC59
Leucine-rich repeat-containing protein 59

2

1

High-throughput

0.584

High

956184

DERL1
Derlin-1

2

3

Small-scale

0.584

High

395793

ESR1
Estrogen receptor

2

3

High-throughput

0.571

High

431046

LA
Lupus La protein

1

2

High-throughput

0.536

High

542411

TOP2A
DNA topoisomerase 2-alpha

1

1

High-throughput

0.536

High

581471

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

1

High-throughput

0.536

High

687178

HMGB2
High mobility group protein B2

1

1

High-throughput

0.536

High

785036

RL4
Large ribosomal subunit protein uL4

1

2

High-throughput

0.536

High

831980

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

4

High-throughput

0.536

High

859174

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.536

High

930841

HSP72
Heat shock-related 70 kDa protein 2

1

2

High-throughput

0.536

High

934041

XPO2
Exportin-2

1

3

High-throughput

0.536

High

956129

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

956136

RT11
Small ribosomal subunit protein uS11m

1

3

High-throughput

0.536

High

956137

RL19
Large ribosomal subunit protein eL19

1

1

High-throughput

0.536

High

956148

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.536

High

956153

CAPR1
Caprin-1

1

1

High-throughput

0.536

High

956173

PSPC1
Paraspeckle component 1

1

1

High-throughput

0.536

High

956183

DNJC2
DnaJ homolog subfamily C member 2

1

2

High-throughput

0.536

High

956193

DUS22
Dual specificity protein phosphatase 22

1

2

High-throughput

0.536

High

956194

STK26
Serine/threonine-protein kinase 26

1

1

High-throughput

0.536

High

956204

G3BP2
Ras GTPase-activating protein-binding protein 2

1

2

High-throughput

0.536

High

346939

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.513

High

446824

NPM
Nucleophosmin

1

0

High-throughput

0.513

High

567332

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.513

High

866957

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

872133

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.513

High

886388

CTCF
Transcriptional repressor CTCF

1

0

High-throughput

0.513

High

896963

MAP2
Methionine aminopeptidase 2

1

0

High-throughput

0.513

High

956131

RS11
Small ribosomal subunit protein uS17

1

0

High-throughput

0.513

High

956138

KPCE
Protein kinase C epsilon type

1

0

High-throughput

0.513

High

956141

DHX9
ATP-dependent RNA helicase A

1

0

High-throughput

0.513

High

956149

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

956154

CND2
Condensin complex subunit 2

1

0

High-throughput

0.513

High

956156

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

956161

C102B
Coiled-coil domain-containing protein 102B

1

0

High-throughput

0.513

High

956163

CPLX2
Complexin-2

1

0

High-throughput

0.513

High

956182

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

956185

MND1
Meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.513

High

956191

DMAP1
DNA methyltransferase 1-associated protein 1

1

0

High-throughput

0.513

High

956201

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

High-throughput

0.513

High

956205

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.513

High

956207

ATG4B
Cysteine protease ATG4B

1

0

High-throughput

0.513

High

185571

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.501

High

956140

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

0

High-throughput

0.493

High

906232

SSDH
Succinate-semialdehyde dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

157159

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.479

High

172637

XPO1
Exportin-1

1

2

High-throughput

0.479

High

259706

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

315359

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

345590

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

3

High-throughput

0.479

High

371615

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

400576

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

588354

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

606525

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

611067

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

1

High-throughput

0.479

High

695085

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

713990

PML
Protein PML

1

2

High-throughput

0.479

High

837504

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.479

High

847490

SSRA
Translocon-associated protein subunit alpha

1

1

High-throughput

0.479

High

891086

GSK3A
Glycogen synthase kinase-3 alpha

1

1

High-throughput

0.479

High

891415

GSK3B
Glycogen synthase kinase-3 beta

1

1

High-throughput

0.479

High

894662

EMD
Emerin

1

1

High-throughput

0.479

High

951049

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.479

High

956134

RL31
Large ribosomal subunit protein eL31

1

2

High-throughput

0.479

High

956139

CKAP4
Cytoskeleton-associated protein 4

1

3

High-throughput

0.479

High

956143

STX4
Syntaxin-4

1

2

High-throughput

0.479

High

956146

RFA4
Replication protein A 30 kDa subunit

1

2

High-throughput

0.479

High

956147

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.479

High

956150

STIM1
Stromal interaction molecule 1

1

1

High-throughput

0.479

High

956151

CUL3
Cullin-3

1

1

High-throughput

0.479

High

956152

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

2

High-throughput

0.479

High

956155

TRBP2
RISC-loading complex subunit TARBP2

1

3

High-throughput

0.479

High

956158

LARP7
La-related protein 7

1

2

High-throughput

0.479

High

956162

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

956164

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

956165

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

956170

RN149
E3 ubiquitin-protein ligase RNF149

1

3

High-throughput

0.479

High

956172

GEMI5
Gem-associated protein 5

1

2

Small-scale

0.479

High

956174

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

956178

RN185
E3 ubiquitin-protein ligase RNF185

1

1

Small-scale

0.479

High

956179

DNJC1
DnaJ homolog subfamily C member 1

1

4

High-throughput

0.479

High

956181

SEC62
Translocation protein SEC62

1

1

High-throughput

0.479

High

956188

DERL2
Derlin-2

1

3

Small-scale

0.479

High

956196

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

956199

UBQL2
Ubiquilin-2

1

1

High-throughput

0.479

High

956202

FZR1
Fizzy-related protein homolog

1

2

High-throughput

0.479

High

956209

RBM8A
RNA-binding protein 8A

1

1

High-throughput

0.479

High

131877

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.458

High

167072

GEMI2
Gem-associated protein 2

1

0

Small-scale

0.458

High

369335

A1AT
Alpha-1-antitrypsin

1

0

Small-scale

0.458

High

904522

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

906386

DHB4
Peroxisomal multifunctional enzyme type 2

1

0

High-throughput

0.458

High

944441

GEMI4
Gem-associated protein 4

1

0

Small-scale

0.458

High

956130

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

956133

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

956135

RS21
Small ribosomal subunit protein eS21

1

0

High-throughput

0.458

High

956145

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.458

High

956157

SMN
Survival motor neuron protein

1

0

Small-scale

0.458

High

956168

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

956175

ARHG2
Rho guanine nucleotide exchange factor 2

1

0

Small-scale

0.458

High

956189

DNJC5
DnaJ homolog subfamily C member 5

1

0

High-throughput

0.458

High

956190

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

956197

TES
Testin

1

0

High-throughput

0.458

High

956200

DDX20
Probable ATP-dependent RNA helicase DDX20

1

0

Small-scale

0.458

High

956144

STK4
Serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

956159

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

956160

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.445

High

411676

NTRK1
High affinity nerve growth factor receptor

1

15

High-throughput

0.437

High

767843

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

956142

DDR1
Epithelial discoidin domain-containing receptor 1

1

13

Small-scale

0.437

High

956167

TM11B
Transmembrane protease serine 11B

1

4

High-throughput

0.437

High

956169

CXD3
Gap junction delta-3 protein

1

2

High-throughput

0.437

High

956180

DERL3
Derlin-3

1

3

Small-scale

0.437

High

956192

TMPS4
Transmembrane protease serine 4

1

4

High-throughput

0.437

High

956195

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

1

High-throughput

0.437

High

956203

ALK
ALK tyrosine kinase receptor

1

12

High-throughput

0.437

High

942522

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.426

High

956166

CFA47
Cilia- and flagella-associated protein 47

1

0

High-throughput

0.426

High

956177

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

886695

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

230169

S28A2
Sodium/nucleoside cotransporter 2

1

1

High-throughput

0.407

High

956187

S6A16
Orphan sodium- and chloride-dependent neurotransmitter transporter NTT5

1

2

High-throughput

0.407

High

956206

RT18C
Small ribosomal subunit protein bS18m

1

0

High-throughput

0.279

Low

956186

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025