HitPredict

Interactor 1: PGFRB (P09619)
Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
Gene: PDGFRB

Interactor 2: NCK1 (P16333)
SH2/SH3 adapter protein NCK1 (Cytoplasmic protein NCK1) (NCK adapter protein 1) (Nck-1) (SH2/SH3 adapter protein NCK-alpha)
Gene: NCK1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	1333047, 10026169, 7692233
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1
Common GO terms	GO:0005102 - signaling receptor binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1106 Hs			1 377
+	Hs
		208979 PGFRB_HUMAN (1-1106): 0: 795: 100.00		NCK2_HUMAN (1-376): 7.1e-90: 277: 68.24
+	Hs
		452370 PGFRB_HUMAN (1-1106): 0: 795: 100.00		ABL2_HUMAN (83-375): 1.75e-33: 134: 23.05
+	Mm
		404009 PGFRB_MOUSE (1-1106): 0: 801: 85.44		P85A_MOUSE (241-376): 1.59e-22: 101: 19.57
+	Mm
		404012 PGFRB_MOUSE (1-1106): 0: 801: 85.44		FYN_MOUSE (7-173): 7.13e-21: 96: 15.39
+	Hs
		452361 PGFRB_HUMAN (1-1106): 0: 795: 100.00		P85A_HUMAN (241-376): 1.37e-22: 101: 19.57
+	Hs
		129176 PGFRB_HUMAN (1-1106): 0: 795: 100.00		P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61
+	Hs
		411953 PGFRB_HUMAN (1-1106): 0: 795: 100.00		FYN_HUMAN (7-173): 7.47e-21: 96: 15.39
+	Mm
		404013 PGFRB_MOUSE (1-1106): 0: 801: 85.44		GRB2_MOUSE (1-61): 1.55e-16: 79.4: 29.03
+	Hs
		452338 PGFRB_HUMAN (1-1106): 0: 795: 100.00		SRC_HUMAN (5-114): 1.61e-15: 79.7: 22.32
+	Hs
		452385 PGFRB_HUMAN (1-1106): 0: 795: 100.00		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Hs
		452495 PGFRB_HUMAN (1-1106): 0: 795: 100.00		VAV3_HUMAN (1-58): 1.16e-12: 71.4: 24.59
+	Hs
		433221 PGFRB_HUMAN (1-1106): 0: 795: 100.00		YES_HUMAN (112-218): 4.18e-11: 66.1: 19.27
+	Hs
		452467 PGFRB_HUMAN (1-1106): 0: 795: 100.00		SH3K1_HUMAN (58-207): 2.14e-09: 61.3: 17.76
+	Hs
		557041 PGFRA_HUMAN (3-1106): 0: 716: 42.48		P85A_HUMAN (241-376): 1.37e-22: 101: 19.57
+	Hs
		129191 PGFRA_HUMAN (3-1106): 0: 716: 42.48		P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61
+	Hs
		557088 PGFRA_HUMAN (3-1106): 0: 716: 42.48		GRB2_HUMAN (3-61): 2.12e-16: 79.1: 28.81
+	Mm
		403533 KIT_MOUSE (24-1004): 0: 603: 31.01		P85A_MOUSE (241-376): 1.59e-22: 101: 19.57
+	Mm
		140055 KIT_MOUSE (24-1004): 0: 603: 31.01		P85B_MOUSE (252-376): 2.57e-21: 97.5: 24.41
+	Hs
		129178 KIT_HUMAN (3-1003): 0: 601: 29.99		P85B_HUMAN (100-376): 1.85e-21: 98.3: 16.61
+	Mm
		403541 KIT_MOUSE (24-1004): 0: 603: 31.01		GRB2_MOUSE (1-61): 1.55e-16: 79.4: 29.03