Protein: NEK7
Serine/threonine-protein kinase Nek7 (EC 2.7.11.34) (Never in mitosis A-related kinase 7) (NimA-related protein kinase 7)

Gene: NEK7
Organism: Homo sapiens
Interactions: 224
UniProt ID: Q8TDX7

Gene Ontology (top 5):
GO:0000922 - spindle pole
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1351862

NLRP3
NACHT, LRR and PYD domains-containing protein 3

11

3

Small-scale

0.974

High

1351881

NEK6
Serine/threonine-protein kinase Nek6

6

16

High-throughput

0.950

High

1350542

NEK9
Serine/threonine-protein kinase Nek9

5

18

Small-scale

0.934

High

1228806

ANKS6
Ankyrin repeat and SAM domain-containing protein 6

3

5

High-throughput

0.871

High

1257199

ANKS3
Ankyrin repeat and SAM domain-containing protein 3

3

14

High-throughput

0.871

High

1286370

NEK8
Serine/threonine-protein kinase Nek8

2

19

High-throughput

0.811

High

1351848

ZN669
Zinc finger protein 669

2

5

High-throughput

0.811

High

920135

PLK1
Serine/threonine-protein kinase PLK1

2

17

High-throughput

0.754

High

331777

MTMR5
Myotubularin-related protein 5

1

4

High-throughput

0.691

High

426303

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

2

High-throughput

0.691

High

573591

ENPL
Endoplasmin

1

20

High-throughput

0.691

High

886538

CTCF
Transcriptional repressor CTCF

1

7

High-throughput

0.691

High

1006575

SRPK2
SRSF protein kinase 2

1

20

High-throughput

0.691

High

1038670

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

14

High-throughput

0.691

High

1160216

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

7

High-throughput

0.691

High

1351840

PSPC1
Paraspeckle component 1

1

12

High-throughput

0.691

High

1351843

RREB1
Ras-responsive element-binding protein 1

1

4

High-throughput

0.691

High

1351860

SCYL1
N-terminal kinase-like protein

1

17

High-throughput

0.691

High

1351866

DNJC2
DnaJ homolog subfamily C member 2

1

7

High-throughput

0.691

High

1351877

BICC1
Protein bicaudal C homolog 1

1

15

High-throughput

0.691

High

1351878

ZN556
Zinc finger protein 556

1

8

High-throughput

0.691

High

1351884

ZN331
Zinc finger protein 331

1

6

High-throughput

0.691

High

1351894

ZN214
Zinc finger protein 214

1

4

High-throughput

0.691

High

1351898

G3BP2
Ras GTPase-activating protein-binding protein 2

1

3

High-throughput

0.691

High

991650

DYL1
Dynein light chain 1, cytoplasmic

3

7

High-throughput

0.675

High

165718

PPE1
Serine/threonine-protein phosphatase with EF-hands 1

1

20

High-throughput

0.665

High

897642

RASF2
Ras association domain-containing protein 2

1

16

High-throughput

0.665

High

913963

RBM5
RNA-binding protein 5

1

9

High-throughput

0.665

High

1187777

SP6
Transcription factor Sp6

1

12

High-throughput

0.665

High

1351858

SPF45
Splicing factor 45

1

3

High-throughput

0.665

High

1351882

MYNN
Myoneurin

1

7

High-throughput

0.665

High

1351889

TSAP1
tRNA selenocysteine 1-associated protein 1

1

4

High-throughput

0.665

High

1351896

TPX2
Targeting protein for Xklp2

1

3

High-throughput

0.665

High

1351839

NEK7
Serine/threonine-protein kinase Nek7

1

16

Small-scale

0.647

High

1181487

EMAL3
Echinoderm microtubule-associated protein-like 3

2

12

High-throughput

0.628

High

1351880

EMAL4
Echinoderm microtubule-associated protein-like 4

2

10

Small-scale

0.619

High

136114

PLK4
Serine/threonine-protein kinase PLK4

1

16

Small-scale

0.618

High

242378

PRKN
E3 ubiquitin-protein ligase parkin

1

16

High-throughput

0.618

High

831109

CCNF
Cyclin-F

1

9

High-throughput

0.618

High

1254775

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.618

High

1351876

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.618

High

191373

P4HA2
Prolyl 4-hydroxylase subunit alpha-2

2

0

High-throughput

0.602

High

60838

MBPHL
Myosin-binding protein H-like

1

1

High-throughput

0.594

High

959370

RAP1B
Ras-related protein Rap-1b

1

4

High-throughput

0.594

High

1116349

RAB31
Ras-related protein Rab-31

1

4

High-throughput

0.594

High

1280833

Q7Z780
U2 small nuclear RNA auxiliary factor 1

1

1

High-throughput

0.594

High

1323802

ARG28
Rho guanine nucleotide exchange factor 28

1

5

High-throughput

0.594

High

1351851

RAB3C
Ras-related protein Rab-3C

1

2

High-throughput

0.594

High

771188

APJ
Apelin receptor

1

0

High-throughput

0.578

High

452344

PDIA1
Protein disulfide-isomerase

2

3

High-throughput

0.574

High

1351900

LAMP3
Lysosome-associated membrane glycoprotein 3

2

4

High-throughput

0.574

High

928499

TERF1
Telomeric repeat-binding factor 1

1

0

Small-scale

0.561

High

1351891

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

2

1

High-throughput

0.549

High

130553

SPT5H
Transcription elongation factor SPT5

1

1

High-throughput

0.536

High

138239

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

1

High-throughput

0.536

High

243986

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

17

High-throughput

0.536

High

469310

ASNS
Asparagine synthetase [glutamine-hydrolyzing]

1

1

High-throughput

0.536

High

476175

ANXA5
Annexin A5

1

6

High-throughput

0.536

High

547659

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

2

High-throughput

0.536

High

551172

PCNA
Proliferating cell nuclear antigen

1

4

High-throughput

0.536

High

559427

XRCC5
X-ray repair cross-complementing protein 5

1

3

High-throughput

0.536

High

565984

EF2
Elongation factor 2

1

8

High-throughput

0.536

High

582892

EZRI
Ezrin

1

8

High-throughput

0.536

High

608162

PYRG1
CTP synthase 1

1

1

High-throughput

0.536

High

647609

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

1

High-throughput

0.536

High

657914

SYWC
Tryptophan--tRNA ligase, cytoplasmic

1

1

High-throughput

0.536

High

669951

MCM3
DNA replication licensing factor MCM3

1

7

High-throughput

0.536

High

697190

APEX1
DNA repair nuclease/redox regulator APEX1

1

1

High-throughput

0.536

High

712246

TKT
Transketolase

1

6

High-throughput

0.536

High

716327

PRDX6
Peroxiredoxin-6

1

8

High-throughput

0.536

High

749968

KINH
Kinesin-1 heavy chain

1

4

High-throughput

0.536

High

760973

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

2

High-throughput

0.536

High

775578

NU214
Nuclear pore complex protein Nup214

1

8

High-throughput

0.536

High

837410

LAP2A
Lamina-associated polypeptide 2, isoform alpha

1

5

High-throughput

0.536

High

846640

MSH2
DNA mismatch repair protein Msh2

1

3

High-throughput

0.536

High

849384

RANG
Ran-specific GTPase-activating protein

1

4

High-throughput

0.536

High

881081

NASP
Nuclear autoantigenic sperm protein

1

3

High-throughput

0.536

High

881254

FAS
Fatty acid synthase

1

3

High-throughput

0.536

High

884543

SYAC
Alanine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.536

High

894575

GDIB
Rab GDP dissociation inhibitor beta

1

1

High-throughput

0.536

High

910323

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

1

2

High-throughput

0.536

High

920857

ACLY
ATP-citrate synthase

1

2

High-throughput

0.536

High

932491

KAD2
Adenylate kinase 2, mitochondrial

1

2

High-throughput

0.536

High

957449

UBC12
NEDD8-conjugating enzyme Ubc12

1

4

High-throughput

0.536

High

957798

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

4

High-throughput

0.536

High

962989

CH10
10 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.536

High

964380

SUMO2
Small ubiquitin-related modifier 2

1

4

High-throughput

0.536

High

992620

IF5A1
Eukaryotic translation initiation factor 5A-1

1

2

High-throughput

0.536

High

1030746

CAP1
Adenylyl cyclase-associated protein 1

1

1

High-throughput

0.536

High

1048322

LGUL
Lactoylglutathione lyase

1

1

High-throughput

0.536

High

1053038

VMAT2
Synaptic vesicular amine transporter

1

2

High-throughput

0.536

High

1116430

FHL1
Four and a half LIM domains protein 1

1

4

High-throughput

0.536

High

1125167

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

13

High-throughput

0.536

High

1130118

SMC1A
Structural maintenance of chromosomes protein 1A

1

17

High-throughput

0.536

High

1137245

CND1
Condensin complex subunit 1

1

1

High-throughput

0.536

High

1153289

AAAT
Neutral amino acid transporter B(0)

1

3

High-throughput

0.536

High

1218846

GP107
Protein GPR107

1

1

High-throughput

0.536

High

1241012

L2GL2
LLGL scribble cell polarity complex component 2

1

2

High-throughput

0.536

High

1245666

LARP1
La-related protein 1

1

4

High-throughput

0.536

High

1294944

PALB2
Partner and localizer of BRCA2

1

1

High-throughput

0.536

High

1351841

DDX1
ATP-dependent RNA helicase DDX1

1

8

High-throughput

0.536

High

1351842

GCN1
Stalled ribosome sensor GCN1

1

12

High-throughput

0.536

High

1351844

HDAC2
Histone deacetylase 2

1

9

High-throughput

0.536

High

1351847

FUBP2
Far upstream element-binding protein 2

1

15

High-throughput

0.536

High

1351849

GCP3
Gamma-tubulin complex component 3

1

1

High-throughput

0.536

High

1351857

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

1

High-throughput

0.536

High

1351864

TBCB
Tubulin-folding cofactor B

1

10

High-throughput

0.536

High

1351868

CPNE1
Copine-1

1

4

High-throughput

0.536

High

1351885

SMC4
Structural maintenance of chromosomes protein 4

1

10

High-throughput

0.536

High

1351886

OLA1
Obg-like ATPase 1

1

3

High-throughput

0.536

High

1351887

S39A9
Zinc transporter ZIP9

1

2

High-throughput

0.536

High

1351890

EHD2
EH domain-containing protein 2

1

4

High-throughput

0.536

High

1351893

SAE2
SUMO-activating enzyme subunit 2

1

1

High-throughput

0.536

High

1351899

ZC3H4
Zinc finger CCCH domain-containing protein 4

1

4

High-throughput

0.536

High

365433

PGK1
Phosphoglycerate kinase 1

1

0

High-throughput

0.530

High

127379

LEG8
Galectin-8

1

2

High-throughput

0.515

High

273904

CNOT3
CCR4-NOT transcription complex subunit 3

1

1

High-throughput

0.515

High

275907

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

1

6

High-throughput

0.515

High

323940

CMTA2
Calmodulin-binding transcription activator 2

1

8

High-throughput

0.515

High

457579

TBB5
Tubulin beta chain

1

16

High-throughput

0.515

High

480861

LEG1
Galectin-1

1

2

High-throughput

0.515

High

482624

GNAO
Guanine nucleotide-binding protein G(o) subunit alpha

1

5

High-throughput

0.515

High

569441

3BHS1
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1

1

1

High-throughput

0.515

High

848209

MAGA2
Melanoma-associated antigen 2

1

2

High-throughput

0.515

High

851377

PRS6B
26S proteasome regulatory subunit 6B

1

6

High-throughput

0.515

High

1040173

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

11

High-throughput

0.515

High

1098069

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

3

High-throughput

0.515

High

1105064

TCOF
Treacle protein

1

12

High-throughput

0.515

High

1278043

MAVS
Mitochondrial antiviral-signaling protein

1

7

High-throughput

0.515

High

1280357

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

13

High-throughput

0.515

High

1324571

PIAS4
E3 SUMO-protein ligase PIAS4

1

2

High-throughput

0.515

High

1334153

POC1A
POC1 centriolar protein homolog A

1

7

High-throughput

0.515

High

1351850

DDT4L
DNA damage-inducible transcript 4-like protein

1

3

High-throughput

0.515

High

1351873

THAP7
THAP domain-containing protein 7

1

2

High-throughput

0.515

High

1351902

PYGO1
Pygopus homolog 1

1

3

High-throughput

0.515

High

1351904

SERC
Phosphoserine aminotransferase

1

1

High-throughput

0.515

High

165063

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

0

High-throughput

0.513

High

646899

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.513

High

925955

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

0

High-throughput

0.513

High

1164002

HCDH
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

1278842

DCXR
L-xylulose reductase

1

0

High-throughput

0.513

High

1351845

GGH
Gamma-glutamyl hydrolase

1

0

High-throughput

0.513

High

1351846

GSLG1
Golgi apparatus protein 1

1

0

High-throughput

0.513

High

1351854

DPH3
Diphthamide biosynthesis protein 3

1

0

High-throughput

0.513

High

1351855

LTV1
Protein LTV1 homolog

1

0

High-throughput

0.513

High

1351865

PARK7
Parkinson disease protein 7

1

0

High-throughput

0.513

High

1351871

PDD2L
Programmed cell death protein 2-like

1

0

High-throughput

0.513

High

296066

IDHC
Isocitrate dehydrogenase [NADP] cytoplasmic

1

0

High-throughput

0.493

High

877752

T23O
Tryptophan 2,3-dioxygenase

1

0

High-throughput

0.493

High

880043

DNSL1
Deoxyribonuclease-1-like 1

1

0

High-throughput

0.493

High

1228230

TPGS2
Tubulin polyglutamylase complex subunit 2

1

0

High-throughput

0.493

High

1314289

DRC7
Dynein regulatory complex subunit 7

1

0

High-throughput

0.493

High

1335535

NF2IP
NFATC2-interacting protein

1

0

High-throughput

0.493

High

1351853

MMAB
Corrinoid adenosyltransferase MMAB

1

0

High-throughput

0.493

High

1351856

FAH2A
Oxaloacetate tautomerase FAHD2A, mitochondrial

1

0

High-throughput

0.493

High

1351861

SPT17
Spermatogenesis-associated protein 17

1

0

High-throughput

0.493

High

1351875

TNMD
Tenomodulin

1

0

High-throughput

0.493

High

1351895

ISY1
Pre-mRNA-splicing factor ISY1 homolog

1

0

High-throughput

0.493

High

158859

AP3D1
AP-3 complex subunit delta-1

1

7

High-throughput

0.489

High

175133

SC16A
Protein transport protein Sec16A

1

3

High-throughput

0.489

High

336996

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

3

High-throughput

0.489

High

446449

G6PI
Glucose-6-phosphate isomerase

1

1

High-throughput

0.489

High

1128927

I13R2
Interleukin-13 receptor subunit alpha-2

1

12

High-throughput

0.489

High

1142341

PDIA6
Protein disulfide-isomerase A6

1

5

High-throughput

0.489

High

1158688

DPYL2
Dihydropyrimidinase-related protein 2

1

2

High-throughput

0.489

High

1219262

ULBP6
UL16-binding protein 6

1

5

High-throughput

0.489

High

1281002

FLIP1
Filamin-A-interacting protein 1

1

20

High-throughput

0.489

High

1311005

SULF2
Extracellular sulfatase Sulf-2

1

1

High-throughput

0.489

High

1338467

PCAT1
Lysophosphatidylcholine acyltransferase 1

1

4

High-throughput

0.489

High

1351883

LUC7L
Putative RNA-binding protein Luc7-like 1

1

1

High-throughput

0.489

High

1351901

LC7L2
Putative RNA-binding protein Luc7-like 2

1

1

High-throughput

0.489

High

1351903

PCDGD
Protocadherin gamma-B1

1

5

High-throughput

0.489

High

340915

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

10

High-throughput

0.479

High

355565

NSD2
Histone-lysine N-methyltransferase NSD2

1

8

Small-scale

0.479

High

372657

MYC
Myc proto-oncogene protein

1

13

High-throughput

0.479

High

639274

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

8

Small-scale

0.479

High

696020

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

6

High-throughput

0.479

High

712879

CASP1
Caspase-1

1

5

Small-scale

0.479

High

768718

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

771915

CBS
Cystathionine beta-synthase

1

1

High-throughput

0.479

High

837739

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

5

High-throughput

0.479

High

1113798

CUL3
Cullin-3

1

9

High-throughput

0.479

High

1163743

PTN21
Tyrosine-protein phosphatase non-receptor type 21

1

17

High-throughput

0.479

High

1276525

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

8

High-throughput

0.479

High

1294320

TRI50
E3 ubiquitin-protein ligase TRIM50

1

10

Small-scale

0.479

High

1338244

WDR19
WD repeat-containing protein 19

1

14

High-throughput

0.479

High

1351879

IF122
Intraflagellar transport protein 122 homolog

1

11

High-throughput

0.479

High

1351892

WDR35
WD repeat-containing protein 35

1

9

High-throughput

0.479

High

1351897

ASC
Apoptosis-associated speck-like protein containing a CARD

1

4

Small-scale

0.479

High

49141

A0JP07
IQ domain-containing protein N

1

2

High-throughput

0.470

High

104729

F6Y2X3
Tafazzin family protein

1

1

High-throughput

0.470

High

688599

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

5

High-throughput

0.470

High

783015

CXA5
Gap junction alpha-5 protein

1

2

High-throughput

0.470

High

888472

TSP3
Thrombospondin-3

1

8

High-throughput

0.470

High

1009157

DRB3
HLA class II histocompatibility antigen, DR beta 3 chain

1

6

High-throughput

0.470

High

1249897

CREL2
Protein disulfide isomerase CRELD2

1

6

High-throughput

0.470

High

1279571

SPRE2
Sprouty-related, EVH1 domain-containing protein 2

1

5

High-throughput

0.470

High

1351859

TMX3
Protein disulfide-isomerase TMX3

1

5

High-throughput

0.470

High

1351863

PRAM
PML-RARA-regulated adapter molecule 1

1

7

High-throughput

0.470

High

1351869

EGFL8
Epidermal growth factor-like protein 8

1

7

High-throughput

0.470

High

1026474

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

1136099

PAF15
PCNA-associated factor

1

0

High-throughput

0.458

High

628432

KLK2
Kallikrein-2

1

5

High-throughput

0.407

High

1290457

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

10

High-throughput

0.407

High

378144

TNFA
Tumor necrosis factor

2

0

High-throughput

0.318

High

423923

ALDH2
Aldehyde dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1131333

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.279

Low

1177038

INF2
Inverted formin-2

1

0

High-throughput

0.279

Low

1210357

NU188
Nucleoporin NUP188

1

0

High-throughput

0.279

Low

1351867

ACON
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.279

Low

596580

EPCAM
Epithelial cell adhesion molecule

1

0

High-throughput

0.268

Low

1083928

FUT2
Galactoside alpha-(1,2)-fucosyltransferase 2

1

0

High-throughput

0.268

Low

1242379

PBIR3
PABIR family member 1

1

0

High-throughput

0.268

Low

1242798

LEG1H
Protein LEG1 homolog

1

0

High-throughput

0.268

Low

1324679

NXPE1
NXPE family member 1

1

0

High-throughput

0.268

Low

1335986

MFI
Protein MFI

1

0

High-throughput

0.268

Low

1346684

CA216
UPF0500 protein C1orf216

1

0

High-throughput

0.268

Low

1347793

Q8TB02
MGC39372 protein

1

0

High-throughput

0.268

Low

1351852

ZHX1R
Zinc fingers and homeoboxes protein 1, isoform 2

1

0

High-throughput

0.268

Low

1351870

Q9BQ29
THAP4 protein

1

0

High-throughput

0.268

Low

1351888

EVA1B
Protein eva-1 homolog B

1

0

High-throughput

0.268

Low

1351872

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

1

0

High-throughput

0.249

Low

1351874

SHRPN
Sharpin

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025