HitPredict

Interactor 1: PGFRB (P09619)
Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
Gene: PDGFRB

Interactor 2: PTN1 (P18031)
Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)
Gene: PTPN1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	19167335, 12614164, 9355745
Identification Methods	phosphatase assay, affinity technology, anti tag coimmunoprecipitation
Interaction Type	dephosphorylation reaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005737 - cytoplasm GO:0019899 - enzyme binding GO:0019901 - protein kinase binding GO:0035791 - platelet-derived growth factor receptor-beta signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1106 Hs			1 435
+	Hs
		452355 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTPRB_HUMAN (2-311): 4.08e-124: 398: 34.39
+	Hs
		452405 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44
+	Hs
		452398 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTN12_HUMAN (24-314): 1e-122: 376: 33.55
+	Hs
		452411 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTPRS_HUMAN (1-278): 3.66e-109: 355: 30.74
+	Hs
		452356 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTPRE_HUMAN (3-278): 1.26e-92: 295: 26.71
+	Hs
		441166 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTPRC_HUMAN (16-337): 3.28e-77: 263: 22.95
+	Hs
		452426 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTPRK_HUMAN (6-279): 1.27e-61: 218: 25.18
+	Hs
		499261 KIT_HUMAN (3-1003): 0: 601: 29.99		PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44
+	Hs
		499258 KIT_HUMAN (3-1003): 0: 601: 29.99		PTN12_HUMAN (24-314): 1e-122: 376: 33.55
+	Hs
		452433 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTPRO_HUMAN (20-274): 4.19e-48: 178: 38.31
+	Hs
		452399 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80
+	Hs
		452357 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTPRG_HUMAN (342-435): 1.43e-21: 99.7: 13.46
+	Hs
		557099 PGFRA_HUMAN (3-1106): 0: 716: 42.48		PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80
+	Hs
		452498 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTN22_HUMAN (297-430): 8.46e-19: 91.2: 13.10
+	Hs
		452363 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTN6_HUMAN (342-432): 1.75e-12: 71.2: 10.48
+	Hs
		499270 KIT_HUMAN (3-1003): 0: 601: 29.99		PTPRO_HUMAN (20-274): 4.19e-48: 178: 38.31
+	Hs
		499259 KIT_HUMAN (3-1003): 0: 601: 29.99		PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80
+	Hs
		738197 FLT3_HUMAN (21-1008): 7e-168: 522: 26.73		PTN11_HUMAN (39-274): 7.78e-49: 177: 38.80
+	Hs
		499281 KIT_HUMAN (3-1003): 0: 601: 29.99		PTPRU_HUMAN (341-434): 6.63e-17: 85.4: 13.59
+	Hs
		499236 KIT_HUMAN (3-1003): 0: 601: 29.99		PTN6_HUMAN (342-432): 1.75e-12: 71.2: 10.48