HitPredict

Interactor 1: PGFRB (P09619)
Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
Gene: PDGFRB

Interactor 2: PTPRE (P23469)
Receptor-type tyrosine-protein phosphatase epsilon (Protein-tyrosine phosphatase epsilon) (R-PTP-epsilon) (EC 3.1.3.48)
Gene: PTPRE

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	19167335
Identification Methods	phosphatase assay
Interaction Type	dephosphorylation reaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1106 Hs			1 700
+	Hs
		452411 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTPRS_HUMAN (1-697): 0: 886: 40.50
+	Hs
		452357 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTPRG_HUMAN (11-695): 0: 745: 32.78
+	Rn
		976067 NTRK3_RAT (65-966): 4.84e-137: 437: 16.32		PTPRS_RAT (1-697): 0: 891: 40.85
+	Hs
		1031989 NTRK3_HUMAN (65-966): 1.49e-133: 427: 16.58		PTPRS_HUMAN (1-697): 0: 886: 40.50
+	Hs
		499281 KIT_HUMAN (3-1003): 0: 601: 29.99		PTPRU_HUMAN (7-694): 0: 712: 32.52
+	Hs
		452405 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTPRJ_HUMAN (409-695): 5.77e-113: 371: 36.81
+	Hs
		452355 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTPRB_HUMAN (336-692): 2.25e-108: 363: 30.66
+	Hs
		507980 FGFR1_HUMAN (218-720): 1.52e-70: 254: 20.44		PTPRS_HUMAN (1-697): 0: 886: 40.50
+	Hs
		452433 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTPRO_HUMAN (400-696): 1.58e-103: 344: 31.89
+	Hs
		452346 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTN1_HUMAN (425-700): 3.73e-109: 339: 26.35
+	Hs
		441166 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTPRC_HUMAN (119-409): 3.12e-76: 268: 30.63
+	Hs
		452426 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PTPRK_HUMAN (122-398): 9.09e-62: 226: 32.39
+	Hs
		499261 KIT_HUMAN (3-1003): 0: 601: 29.99		PTPRJ_HUMAN (409-695): 5.77e-113: 371: 36.81
+	Hs
		499270 KIT_HUMAN (3-1003): 0: 601: 29.99		PTPRO_HUMAN (400-696): 1.58e-103: 344: 31.89
+	Hs
		169163 MUSK_HUMAN (120-966): 1.11e-145: 460: 16.48		PTN1_HUMAN (425-700): 3.73e-109: 339: 26.35
+	Hs
		573716 NTRK3_HUMAN (65-966): 1.49e-133: 427: 16.58		PTN1_HUMAN (425-700): 3.73e-109: 339: 26.35
+	Hs
		445820 ROS1_HUMAN (118-1073): 2.6e-112: 388: 16.99		PTN1_HUMAN (425-700): 3.73e-109: 339: 26.35
+	Hs
		507839 FGFR1_HUMAN (218-720): 1.52e-70: 254: 20.44		PTN1_HUMAN (425-700): 3.73e-109: 339: 26.35
+	Hs
		572628 VGFR1_HUMAN (33-627): 2.19e-51: 200: 18.47		PTPRJ_HUMAN (409-695): 5.77e-113: 371: 36.81
+	Hs
		572587 VGFR1_HUMAN (33-627): 2.19e-51: 200: 18.47		PTPRB_HUMAN (336-692): 2.25e-108: 363: 30.66