HitPredict

Interactor 1: PGFRB (P09619)
Platelet-derived growth factor receptor beta (PDGF-R-beta) (PDGFR-beta) (EC 2.7.10.1) (Beta platelet-derived growth factor receptor) (Beta-type platelet-derived growth factor receptor) (CD140 antigen-like family member B) (Platelet-derived growth factor receptor 1) (PDGFR-1) (CD antigen CD140b)
Gene: PDGFRB

Interactor 2: GRB7 (Q14451)
Growth factor receptor-bound protein 7 (B47) (Epidermal growth factor receptor GRB-7) (GRB7 adapter protein)
Gene: GRB7

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	8940081
Identification Methods	affinity chromatography technology, pull down, competition binding
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	BPS~PK_Tyr_Ser-Thr, PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0005925 - focal adhesion GO:0019901 - protein kinase binding GO:0030335 - positive regulation of cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1106 Hs			1 532
+	Hs
		452423 PGFRB_HUMAN (1-1106): 0: 795: 100.00		GRB14_HUMAN (12-532): 0: 614: 47.91
+	Hs
		452410 PGFRB_HUMAN (1-1106): 0: 795: 100.00		GRB10_HUMAN (1-532): 0: 593: 53.17
+	Hs
		452342 PGFRB_HUMAN (1-1106): 0: 795: 100.00		VAV_HUMAN (84-526): 4.42e-86: 285: 15.27
+	Hs
		452375 PGFRB_HUMAN (1-1106): 0: 795: 100.00		VAV2_HUMAN (81-526): 4.93e-78: 264: 14.77
+	Hs
		452495 PGFRB_HUMAN (1-1106): 0: 795: 100.00		VAV3_HUMAN (81-526): 1.65e-62: 221: 10.44
+	Mm
		404014 PGFRB_MOUSE (1-1106): 0: 801: 85.44		PLCG1_MOUSE (200-532): 1.92e-49: 185: 14.97
+	Mm
		404012 PGFRB_MOUSE (1-1106): 0: 801: 85.44		FYN_MOUSE (357-529): 5.57e-50: 182: 20.88
+	Hs
		452348 PGFRB_HUMAN (1-1106): 0: 795: 100.00		PLCG1_HUMAN (200-532): 6.64e-50: 187: 14.69
+	Hs
		411953 PGFRB_HUMAN (1-1106): 0: 795: 100.00		FYN_HUMAN (357-529): 5.57e-50: 182: 20.88
+	Hs
		433221 PGFRB_HUMAN (1-1106): 0: 795: 100.00		YES_HUMAN (366-528): 8.94e-48: 175: 19.53
+	Hs
		452338 PGFRB_HUMAN (1-1106): 0: 795: 100.00		SRC_HUMAN (351-528): 1.08e-46: 172: 24.32
+	Hs
		557029 PGFRA_HUMAN (3-1106): 0: 716: 42.48		PLCG1_HUMAN (200-532): 6.64e-50: 187: 14.69
+	Mm
		403536 KIT_MOUSE (24-1004): 0: 603: 31.01		VAV_MOUSE (85-526): 8.09e-90: 295: 15.52
+	Rn
		595729 PGFRA_RAT (5-1106): 0: 709: 42.02		LYN_RAT (347-531): 2.72e-49: 179: 18.46
+	Mm
		404013 PGFRB_MOUSE (1-1106): 0: 801: 85.44		GRB2_MOUSE (427-513): 2.66e-13: 71: 29.89
+	Hs
		452385 PGFRB_HUMAN (1-1106): 0: 795: 100.00		GRB2_HUMAN (427-513): 2.66e-13: 71: 29.89
+	Hs
		557088 PGFRA_HUMAN (3-1106): 0: 716: 42.48		GRB2_HUMAN (427-513): 2.66e-13: 71: 29.89
+	Mm
		403538 KIT_MOUSE (24-1004): 0: 603: 31.01		MATK_MOUSE (398-525): 1.43e-39: 152: 30.37
+	Mm
		403542 KIT_MOUSE (24-1004): 0: 603: 31.01		GRB10_MOUSE (2-77): 1.15e-12: 72.6: 33.33
+	Mm
		403541 KIT_MOUSE (24-1004): 0: 603: 31.01		GRB2_MOUSE (427-513): 2.66e-13: 71: 29.89