HitPredict

Interactor 1: DLDH (P09624)
Dihydrolipoyl dehydrogenase, mitochondrial (DLD) (EC 1.8.1.4) (2-oxoglutarate dehydrogenase complex component E3) (OGDC-E3) (OGDHC subunit E3) (Alpha-ketoglutarate dehydrogenase complex subunit E3) (alpha-KGDHC subunit E3) (Dihydrolipoamide dehydrogenase) (Dihydrolipoamide:NAD(+) oxidoreductase) (Glycine decarboxylase complex subunit L) (GDC subunit L) (Lipoamide dehydrogenase component of pyruvate dehydrogenase complex) (Pyruvate dehydrogenase complex E3 component) (PDC subunit E3) (PDH complex subunit E3)
Gene: LPD1

Interactor 2: ODO2 (P19262)
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST) (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (OGDHC subunit E2) (Alpha-ketoglutarate dehydrogenase subunit E2) (alpha-KGDHC subunit E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex)
Gene: KGD2

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.748

Property	Details
Experiments	8575446, 2072900, 11805826, 16429126, 25165143, 32051233, 37968396
Identification Methods	biochemical, biophysical, cosedimentation through density gradient, tandem affinity purification, affinity chromatography technology, cross-linking study, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0006103 - 2-oxoglutarate metabolic process GO:0042645 - mitochondrial nucleoid
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 499 Sc			1 463
+	Dm
		114448 Q9VVL7_DROME (13-498): 4.89e-155: 452: 55.53		M9PCG1_DROME (5-462): 2.98e-161: 466: 23.66
+	Hs
		452591 DLDH_HUMAN (4-498): 7.46e-157: 457: 54.20		ODB2_HUMAN (36-462): 4e-157: 455: 24.30
+	Hs
		452657 DLDH_HUMAN (4-498): 7.46e-157: 457: 54.20		ODO2_HUMAN (1-462): 3.05e-157: 454: 40.85
+	Sc
		452941 DLDH_YEAST (1-499): 4.29e-169: 488: 100.00		ODP2_YEAST (49-462): 2.97e-124: 372: 24.16
+	Hs
		126212 DLDH_HUMAN (4-498): 7.46e-157: 457: 54.20		ODPX_HUMAN (60-460): 4.03e-131: 390: 23.39
+	Gs
		516781 DLDH1_GEOSE (26-498): 1.36e-144: 424: 42.50		ODP2_GEOSE (75-462): 6.12e-134: 394: 28.07
+	Ec
		465061 DLDH_ECOLI (21-491): 3.59e-129: 385: 38.85		ODO2_ECOLI (71-462): 2.58e-143: 417: 42.18
+	At
		67654 PLPD1_ARATH (44-492): 1.59e-119: 365: 31.39		ODP24_ARATH (55-462): 1.6e-120: 362: 20.35
+	Ss
		937183 DLDH_SYNY3 (21-493): 6.82e-119: 359: 34.98		P74510_SYNY3 (75-461): 2.73e-100: 308: 24.77
+	At
		1012986 DLDH1_ARATH (5-498): 2.41e-156: 456: 56.48		ODP21_ARATH (7-212): 3.01e-27: 117: 15.39
+	Hs
		452588 DLDH_HUMAN (4-498): 7.46e-157: 457: 54.20		ODP2_HUMAN (20-209): 3.77e-27: 116: 15.54
+	Ec
		420918 DLDH_ECOLI (21-491): 3.59e-129: 385: 38.85		ODP2_ECOLI (212-462): 3.01e-30: 125: 29.06