HitPredict

Interactor 1: ROA1 (P09651)
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]
Gene: HNRNPA1

Interactor 2: TADBP (Q13148)
TAR DNA-binding protein 43 (TDP-43)
Gene: TARDBP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.873

Property	Details
Experiments	34079125, 17643375, 22446626, 20020773
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003677 - DNA binding GO:0003723 - RNA binding GO:0003730 - mRNA 3'-UTR binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 372 Hs			1 414
+	Hs
		201666 MSI1H_HUMAN (2-340): 5.33e-59: 196: 27.87		TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00
+	Hs
		162032 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00
+	Hs
		161942 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60
+	Hs
		453229 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		ROA3_HUMAN (98-269): 2.33e-69: 225: 28.57
+	Hs
		162063 RA1L2_HUMAN (1-302): 4.03e-58: 193: 83.44		HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60
+	Hs
		161962 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60
+	Hs
		852075 RA1L2_HUMAN (1-302): 4.03e-58: 193: 83.44		ROA3_HUMAN (98-269): 2.33e-69: 225: 28.57
+	Hs
		609770 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		ROA3_HUMAN (98-269): 2.33e-69: 225: 28.57
+	Hs
		201642 MSI1H_HUMAN (2-340): 5.33e-59: 196: 27.87		MSI1H_HUMAN (96-409): 4.25e-61: 203: 23.93
+	Mm
		1142607 MSI1H_MOUSE (2-340): 8.71e-59: 196: 27.87		MSI1H_MOUSE (96-409): 1.97e-60: 201: 23.93
+	Hs
		453331 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		PABP4_HUMAN (98-274): 3.77e-37: 144: 19.02
+	Hs
		162035 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		PABP4_HUMAN (98-274): 3.77e-37: 144: 19.02
+	Hs
		453107 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95
+	Hs
		161948 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95
+	Hs
		516358 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95
+	Hs
		453351 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93
+	Hs
		201699 MSI1H_HUMAN (2-340): 5.33e-59: 196: 27.87		MSI2H_HUMAN (41-207): 5.16e-20: 92.2: 23.81
+	Hs
		1048086 RA1L2_HUMAN (1-302): 4.03e-58: 193: 83.44		HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93
+	Mm
		825781 ROA1_MOUSE (1-302): 7.42e-58: 192: 86.09		HNRPD_MOUSE (81-238): 5.86e-21: 95.1: 35.93
+	Hs
		162045 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93