HitPredict

Interactor 1: ROA1 (P09651)
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) (Helix-destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1) [Cleaved into: Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed]
Gene: HNRNPA1

Interactor 2: CPSF7 (Q8N684)
Cleavage and polyadenylation specificity factor subunit 7 (Cleavage and polyadenylation specificity factor 59 kDa subunit) (CPSF 59 kDa subunit) (Cleavage factor Im complex 59 kDa subunit) (CFIm59) (Pre-mRNA cleavage factor Im 59 kDa subunit)
Gene: CPSF7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 372 Hs			1 471
+	Hs
		609957 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		CPSF7_HUMAN (1-456): 1.39e-122: 367: 100.00
+	Hs
		453387 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		CPSF6_HUMAN (1-451): 1.98e-76: 250: 39.51
+	Hs
		162062 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		CPSF6_HUMAN (1-451): 1.98e-76: 250: 39.51
+	Hs
		609888 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		CPSF6_HUMAN (1-451): 1.98e-76: 250: 39.51
+	Hs
		852074 ROA3_HUMAN (7-202): 5.98e-55: 186: 85.71		CPSF6_HUMAN (1-451): 1.98e-76: 250: 39.51
+	Hs
		1048080 HNRPD_HUMAN (2-101): 4.8e-18: 86.4: 31.00		CPSF6_HUMAN (1-451): 1.98e-76: 250: 39.51
+	Hs
		453647 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		RBM12_HUMAN (70-286): 4.33e-19: 92.6: 18.43
+	Hs
		453331 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		PABP4_HUMAN (73-165): 2.96e-11: 67.6: 18.28
+	Hs
		453107 ROA1_HUMAN (1-372): 3.69e-61: 202: 100.00		PABP1_HUMAN (73-165): 7.95e-10: 63: 19.36
+	Hs
		162035 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		PABP4_HUMAN (73-165): 2.96e-11: 67.6: 18.28
+	Hs
		161948 HNRDL_HUMAN (2-283): 5.5e-56: 190: 32.41		PABP1_HUMAN (73-165): 7.95e-10: 63: 19.36
+	Hs
		516358 ROA2_HUMAN (1-339): 4.42e-56: 188: 59.00		PABP1_HUMAN (73-165): 7.95e-10: 63: 19.36
+	Hs
		516424 ROA3_HUMAN (7-202): 5.98e-55: 186: 85.71		PABP1_HUMAN (73-165): 7.95e-10: 63: 19.36
+	Sc
		376562 PABP_YEAST (4-189): 6.12e-39: 147: 24.47		PABP_YEAST (83-159): 2.45e-16: 83.4: 24.68
+	Hs
		516689 PABP3_HUMAN (6-193): 6.86e-35: 137: 17.90		PABP1_HUMAN (73-165): 7.95e-10: 63: 19.36
+	Hs
		516663 ROAA_HUMAN (6-184): 1.25e-35: 134: 39.44		PABP1_HUMAN (73-165): 7.95e-10: 63: 19.36
+	Hs
		1020249 ELAV2_HUMAN (1-186): 1.4e-22: 99.5: 14.98		PABP4_HUMAN (73-165): 2.96e-11: 67.6: 18.28
+	Hs
		516484 ELAV2_HUMAN (1-186): 1.4e-22: 99.5: 14.98		PABP1_HUMAN (73-165): 7.95e-10: 63: 19.36
+	Hs
		516511 HNRPD_HUMAN (2-101): 4.8e-18: 86.4: 31.00		PABP1_HUMAN (73-165): 7.95e-10: 63: 19.36
+	Hs
		516495 PABP4_HUMAN (102-190): 3.52e-15: 79: 15.56		PABP1_HUMAN (73-165): 7.95e-10: 63: 19.36