Interactor 1: C1S (P09871)
Complement C1s subcomponent (EC 3.4.21.42) (C1 esterase) (Complement component 1 subcomponent s) [Cleaved into: Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain]
Gene: C1S

Interactor 2: C1S (P09871)
Complement C1s subcomponent (EC 3.4.21.42) (C1 esterase) (Complement component 1 subcomponent s) [Cleaved into: Complement C1s subcomponent heavy chain; Complement C1s subcomponent light chain]
Gene: C1S

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.60 1.00 0.778

The method score is based on:

Property Details
Experiments 2387866, 12788922
Identification Methods molecular sieving, x-ray crystallography
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains CUB~CUB, CUB~FXa_inhibition, CUB~Sushi, FXa_inhibition~FXa_inhibition, FXa_inhibition~Trypsin, Sushi~Sushi, Sushi~Trypsin, Trypsin~Trypsin
Common GO terms GO:0004252 - serine-type endopeptidase activity
GO:0005509 - calcium ion binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0006508 - proteolysis
and 3 others

more...

Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 688
Hs

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Last updated: 15 Jul 2024