HitPredict

Interactor 1: PARP1 (P09874)
Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]
Gene: PARP1

Interactor 2: H31 (P68431)
Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
Gene: H3C1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.92	0.60	0.746

Property	Details
Experiments	28190768, 32937373, 29568061, 34079125, 33961781, 36089195, 20504901, 20080577
Identification Methods	enzymatic study, proximity labelling technology, affinity chromatography technology, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0016020 - membrane GO:0032991 - protein-containing complex
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 1014 Hs			1 136
+	Hs
		455497 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H31T_HUMAN (1-136): 1.27e-61: 187: 97.06
+	Hs
		455324 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		455584 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H32_HUMAN (1-136): 6.5e-61: 185: 99.27
+	Hs
		455562 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H3C_HUMAN (1-136): 5.49e-58: 177: 93.38
+	Mm
		935448 Q3UJ03_MOUSE (1-1014): 0: 1333: 91.13		H31_MOUSE (1-136): 2.8e-62: 188: 100.00
+	Mm
		952740 Q3UJ03_MOUSE (1-1014): 0: 1333: 91.13		H33_MOUSE (1-136): 2.73e-61: 186: 96.32
+	Mm
		952254 Q3UJ03_MOUSE (1-1014): 0: 1333: 91.13		H32_MOUSE (1-136): 6.5e-61: 185: 99.27
+	Hs
		455212 PARP1_HUMAN (1-1014): 0: 1362: 100.00		CENPA_HUMAN (9-133): 5.62e-45: 145: 50.00
+	Hs
		935340 PARP2_HUMAN (514-1014): 0: 594: 41.72		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		1086343 PARP2_HUMAN (514-1014): 0: 594: 41.72		H31T_HUMAN (1-136): 1.27e-61: 187: 97.06
+	Hs
		952679 PARP2_HUMAN (514-1014): 0: 594: 41.72		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		1174707 PARP3_HUMAN (485-1005): 1.45e-147: 451: 31.87		H32_HUMAN (1-136): 6.5e-61: 185: 99.27
+	Hs
		836706 DNLI3_HUMAN (3-104): 4.41e-30: 130: 25.46		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		836708 DNLI3_HUMAN (3-104): 4.41e-30: 130: 25.46		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		934836 PAR10_HUMAN (801-1004): 1.15e-19: 97.3: 12.62		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		828173 DNLI3_HUMAN (3-104): 4.41e-30: 130: 25.46		CENPA_HUMAN (9-133): 5.62e-45: 145: 50.00