HitPredict

Interactor 1: PARP1 (P09874)
Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]
Gene: PARP1

Interactor 2: H2A2A (Q6FI13)
Histone H2A type 2-A (H2A-clustered histone 18) (H2A-clustered histone 19) (Histone H2A.2) (Histone H2A/o)
Gene: H2AC18

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	20525793
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1014 Hs			1 130
+	Hs
		455732 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H2A1C_HUMAN (1-130): 5.62e-67: 200: 98.46
+	Hs
		391516 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H2A1B_HUMAN (1-130): 9.51e-67: 199: 96.92
+	Hs
		455012 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H2A1_HUMAN (1-130): 6.85e-67: 199: 98.46
+	Hs
		455802 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H2A1J_HUMAN (1-128): 2.76e-66: 198: 97.66
+	Hs
		455622 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H2A2B_HUMAN (1-130): 1.54e-65: 196: 94.62
+	Hs
		455818 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H2AJ_HUMAN (1-128): 2.61e-64: 193: 94.53
+	Hs
		455054 PARP1_HUMAN (1-1014): 0: 1362: 100.00		H2AX_HUMAN (1-130): 3.33e-63: 190: 88.81
+	Dm
		728986 PARP_DROME (6-1009): 0: 1046: 41.29		H2A_DROME (17-125): 2.5e-59: 180: 89.91
+	Hs
		1151393 PARP2_HUMAN (514-1014): 0: 594: 41.72		H2A2A_HUMAN (1-130): 4.66e-67: 200: 100.00
+	Hs
		391953 PARP2_HUMAN (514-1014): 0: 594: 41.72		H2A1B_HUMAN (1-130): 9.51e-67: 199: 96.92
+	Hs
		470599 PARP2_HUMAN (514-1014): 0: 594: 41.72		H2A1_HUMAN (1-130): 6.85e-67: 199: 98.46
+	Hs
		1087127 PARP2_HUMAN (514-1014): 0: 594: 41.72		H2A2C_HUMAN (1-128): 2.7e-64: 193: 96.88
+	Hs
		555678 PARP2_HUMAN (514-1014): 0: 594: 41.72		H2AX_HUMAN (1-130): 3.33e-63: 190: 88.81
+	Hs
		391601 DNLI3_HUMAN (3-104): 4.41e-30: 130: 25.46		H2A1B_HUMAN (1-130): 9.51e-67: 199: 96.92
+	Hs
		470301 DNLI3_HUMAN (3-104): 4.41e-30: 130: 25.46		H2A1_HUMAN (1-130): 6.85e-67: 199: 98.46
+	Hs
		836737 DNLI3_HUMAN (3-104): 4.41e-30: 130: 25.46		H2A2C_HUMAN (1-128): 2.7e-64: 193: 96.88
+	Hs
		555353 DNLI3_HUMAN (3-104): 4.41e-30: 130: 25.46		H2AX_HUMAN (1-130): 3.33e-63: 190: 88.81
+	Hs
		470434 ZCCHV_HUMAN (798-1005): 5.42e-21: 101: 15.71		H2A1_HUMAN (1-130): 6.85e-67: 199: 98.46
+	Hs
		555522 ZCCHV_HUMAN (798-1005): 5.42e-21: 101: 15.71		H2AX_HUMAN (1-130): 3.33e-63: 190: 88.81
+	Hs
		1087011 PAR10_HUMAN (801-1004): 1.15e-19: 97.3: 12.62		H2A2C_HUMAN (1-128): 2.7e-64: 193: 96.88