Protein: SYTC
Threonine--tRNA ligase, cytoplasmic (EC 6.1.1.3) (Threonyl-tRNA synthetase) (ThrRS)

Gene: SYTC, THS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 119
UniProt ID: P04801

Gene Ontology (top 5):
GO:0004829 - threonine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0006435 - threonyl-tRNA aminoacylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

416057

SYTC
Threonine--tRNA ligase, cytoplasmic

2

14

High-throughput

0.776

High

416093

HS104
Heat shock protein 104

3

3

Small-scale

0.640

High

416132

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

3

2

High-throughput

0.640

High

416063

SYH
Histidine--tRNA ligase, mitochondrial

1

1

High-throughput

0.618

High

416113

SYG
Glycine--tRNA ligase 1, mitochondrial

1

9

High-throughput

0.618

High

416119

YHI0
Putative proline--tRNA ligase YHR020W

1

12

High-throughput

0.618

High

416073

SSB1
Ribosome-associated molecular chaperone SSB1

2

4

High-throughput

0.611

High

416084

SIS1
Protein SIS1

3

4

High-throughput

0.587

High

391953

HSP82
ATP-dependent molecular chaperone HSP82

2

9

Small-scale

0.584

High

416076

HSC82
ATP-dependent molecular chaperone HSC82

2

9

High-throughput

0.571

High

416167

RRP6
Exosome complex exonuclease RRP6

2

3

High-throughput

0.558

High

416127

SSB2
Ribosome-associated molecular chaperone SSB2

2

4

High-throughput

0.552

High

416080

FKBP
FK506-binding protein 1

1

6

High-throughput

0.536

High

416106

PTK1
Serine/threonine-protein kinase PTK1/STK1

1

4

High-throughput

0.536

High

416109

MAOM
NAD-dependent malic enzyme, mitochondrial

1

1

High-throughput

0.536

High

416144

BRE5
UBP3-associated protein BRE5

1

4

High-throughput

0.536

High

416147

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

416150

YMY9
Glucose-6-phosphate 1-epimerase

1

0

High-throughput

0.513

High

416103

HSL1
Probable serine/threonine-protein kinase HSL1

1

4

High-throughput

0.501

High

416116

RCK1
Serine/threonine-protein kinase RCK1

1

1

High-throughput

0.501

High

416117

KSP1
Serine/threonine-protein kinase KSP1

1

3

High-throughput

0.501

High

416135

GYP7
GTPase-activating protein GYP7

1

0

High-throughput

0.493

High

416079

MYO2
Myosin-2

1

1

Small-scale

0.481

High

416159

PIN3
[PSI+] inducibility protein 3

1

1

Small-scale

0.481

High

149460

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.479

High

368843

SYMC
Methionine--tRNA ligase, cytoplasmic

1

11

High-throughput

0.479

High

416058

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

10

High-throughput

0.479

High

416060

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

416061

SC160
Protein SCP160

1

3

High-throughput

0.479

High

416064

SYV
Valine--tRNA ligase, mitochondrial

1

10

High-throughput

0.479

High

416066

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

10

Small-scale

0.479

High

416070

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.479

High

416074

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.479

High

416075

SYQ
Glutamine--tRNA ligase

1

7

High-throughput

0.479

High

416077

SYKC
Lysine--tRNA ligase, cytoplasmic

1

11

High-throughput

0.479

High

416082

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

1

High-throughput

0.479

High

416083

IF5A1
Eukaryotic translation initiation factor 5A-1

1

3

High-throughput

0.479

High

416086

RS2
Small ribosomal subunit protein uS5

1

3

High-throughput

0.479

High

416087

CDC48
Cell division control protein 48

1

5

High-throughput

0.479

High

416088

SYLC
Leucine--tRNA ligase, cytoplasmic

1

12

High-throughput

0.479

High

416092

BMH1
Protein BMH1

1

1

High-throughput

0.479

High

416095

HOG1
Mitogen-activated protein kinase HOG1

1

3

High-throughput

0.479

High

416096

ZUO1
Zuotin

1

5

High-throughput

0.479

High

416098

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

1

High-throughput

0.479

High

416099

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

416101

PRS6A
26S proteasome regulatory subunit 6A

1

3

High-throughput

0.479

High

416105

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.479

High

416107

KKQ8
Probable serine/threonine-protein kinase KKQ8

1

6

High-throughput

0.479

High

416108

EF1G2
Elongation factor 1-gamma 2

1

4

High-throughput

0.479

High

416110

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

4

High-throughput

0.479

High

416111

LONM
Lon protease homolog, mitochondrial

1

8

High-throughput

0.479

High

416112

RM16
Large ribosomal subunit protein uL16m

1

1

High-throughput

0.479

High

416115

ATG8
Autophagy-related protein 8

1

3

High-throughput

0.479

High

416118

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

10

High-throughput

0.479

High

416120

RPN1
26S proteasome regulatory subunit RPN1

1

2

High-throughput

0.479

High

416121

SSZ1
Ribosome-associated complex subunit SSZ1

1

3

High-throughput

0.479

High

416123

DHH1
ATP-dependent RNA helicase DHH1

1

2

High-throughput

0.479

High

416129

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

1

High-throughput

0.479

High

416130

TM108
Protein TMA108

1

1

High-throughput

0.479

High

416134

MPS3
Spindle pole body assembly component MPS3

1

1

High-throughput

0.479

High

416136

HOSC
Homocitrate synthase, cytosolic isozyme

1

2

High-throughput

0.479

High

416137

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

416141

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.479

High

416142

SPC98
Spindle pole body component SPC98

1

1

High-throughput

0.479

High

416143

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

2

High-throughput

0.479

High

416145

PDR16
Phosphatidylinositol transfer protein PDR16

1

1

High-throughput

0.479

High

416146

NUM1
Nuclear migration protein NUM1

1

2

High-throughput

0.479

High

416149

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

416151

TOM1
E3 ubiquitin-protein ligase TOM1

1

6

High-throughput

0.479

High

416153

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

1

High-throughput

0.479

High

416160

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.479

High

416168

DBP10
ATP-dependent RNA helicase DBP10

1

4

High-throughput

0.479

High

416065

PBS2
MAP kinase kinase PBS2

1

0

High-throughput

0.458

High

416081

ATP5E
ATP synthase subunit epsilon, mitochondrial

1

0

High-throughput

0.458

High

416085

RBSK
Ribokinase

1

0

High-throughput

0.458

High

416131

MMM1
Maintenance of mitochondrial morphology protein 1

1

0

High-throughput

0.458

High

416154

VMS1
tRNA endonuclease VMS1

1

0

High-throughput

0.458

High

416161

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

416164

TIM18
Mitochondrial import inner membrane translocase subunit TIM18

1

0

High-throughput

0.458

High

416166

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.458

High

416162

ESA1
Histone acetyltransferase ESA1

1

1

Small-scale

0.457

High

416068

HSP77
Import motor subunit, mitochondrial

1

7

High-throughput

0.445

High

416071

HSP71
Heat shock protein SSA1

1

4

High-throughput

0.445

High

416072

HSP72
Heat shock protein SSA2

1

4

High-throughput

0.445

High

416078

BIP
Endoplasmic reticulum chaperone BiP

1

2

High-throughput

0.445

High

416097

HSP7F
Heat shock protein homolog SSE1

1

6

High-throughput

0.445

High

416102

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.445

High

416126

HSP7E
Heat shock protein SSC3, mitochondrial

1

7

High-throughput

0.445

High

416139

INO80
Chromatin-remodeling ATPase INO80

1

3

High-throughput

0.445

High

416059

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

416062

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.437

High

416067

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

416091

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

416094

MET4
Transcriptional activator of sulfur metabolism MET4

1

1

High-throughput

0.437

High

416122

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.437

High

416125

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

416138

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.437

High

416140

EIF2A
Eukaryotic translation initiation factor 2A

1

1

High-throughput

0.437

High

416148

MAP1
Methionine aminopeptidase 1

1

1

High-throughput

0.437

High

416152

YMC0
Uncharacterized protein YML020W

1

1

High-throughput

0.437

High

416158

TFC6
Transcription factor tau 91 kDa subunit

1

1

High-throughput

0.437

High

416163

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.437

High

416165

AP3D
AP-3 complex subunit delta

1

2

High-throughput

0.437

High

416124

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.426

High

416156

YL287
Uncharacterized protein YLR287C

1

0

High-throughput

0.426

High

416089

LAC1
Ceramide synthase LAC1

1

1

High-throughput

0.407

High

416128

ELO3
Fatty acid elongase 3

1

1

High-throughput

0.407

High

416155

SEN15
tRNA-splicing endonuclease subunit SEN15

1

0

High-throughput

0.279

Low

416133

TRS85
Trafficking protein particle complex III-specific subunit 85

1

0

High-throughput

0.269

Low

416100

PRP40
Pre-mRNA-processing protein PRP40

1

0

High-throughput

0.261

Low

416069

RL18B
Large ribosomal subunit protein eL18B

1

0

High-throughput

0.249

Low

416104

SPT10
Protein SPT10

1

0

High-throughput

0.249

Low

416114

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

416157

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

416169

EMC6
ER membrane protein complex subunit 6

1

0

High-throughput

0.249

Low

416170

RKM4
Ribosomal lysine N-methyltransferase 4

1

0

High-throughput

0.249

Low

416171

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

High-throughput

0.249

Low

416090

SEC20
Protein transport protein SEC20

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025