HitPredict

Interactor 1: PARP1 (P09874)
Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]
Gene: PARP1

Interactor 2: CTR9 (Q6PD62)
RNA polymerase-associated protein CTR9 homolog (SH2 domain-binding protein 1)
Gene: CTR9

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	34079125, 35013556
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1014 Hs			1 1173
+	Hs
		174569 PARP1_HUMAN (1-1014): 0: 1362: 100.00		OGT1_HUMAN (10-501): 1.15e-43: 175: 13.19
+	Hs
		455571 PARP1_HUMAN (1-1014): 0: 1362: 100.00		SKI3_HUMAN (9-514): 3.93e-11: 69.9: 9.36
+	Hs
		300038 PARP1_HUMAN (1-1014): 0: 1362: 100.00		PRP6_HUMAN (32-285): 7.01e-11: 68.7: 12.02
+	Hs
		1160933 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		CTR9_HUMAN (1-1173): 0: 592: 100.00
+	Hs
		175001 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		OGT1_HUMAN (10-501): 1.15e-43: 175: 13.19
+	Hs
		183130 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		KDM6A_HUMAN (4-261): 4.06e-20: 99.1: 11.03
+	Hs
		1161392 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		SKI3_HUMAN (9-514): 3.93e-11: 69.9: 9.36
+	Hs
		300191 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		PRP6_HUMAN (32-285): 7.01e-11: 68.7: 12.02
+	Hs
		174998 ZCCHV_HUMAN (798-1005): 5.42e-21: 101: 15.71		OGT1_HUMAN (10-501): 1.15e-43: 175: 13.19