HitPredict

Interactor 1: PARP1 (P09874)
Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]
Gene: PARP1

Interactor 2: APTX (Q7Z2E3)
Aprataxin (EC 3.6.1.71) (EC 3.6.1.72) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT)
Gene: APTX

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.692

Property	Details
Experiments	15555565, 15044383, 35271311
Identification Methods	affinity chromatography technology, two hybrid, pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0003682 - chromatin binding GO:0003684 - damaged DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm and 1 others more... GO:0005730 - nucleolus
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 1014 Hs			1 356
+	Hs
		455785 PARP1_HUMAN (1-1014): 0: 1362: 100.00		PNKP_HUMAN (20-155): 1.27e-57: 196: 34.31
+	Hs
		455219 PARP1_HUMAN (1-1014): 0: 1362: 100.00		HINT1_HUMAN (161-296): 6.3e-50: 164: 21.74
+	Hs
		836745 DNLI3_HUMAN (3-104): 4.41e-30: 130: 25.46		APTX_HUMAN (1-356): 2e-177: 498: 100.00
+	Hs
		836767 DNLI3_HUMAN (3-104): 4.41e-30: 130: 25.46		PNKP_HUMAN (20-155): 1.27e-57: 196: 34.31