HitPredict

Interactor 1: PARP1 (P09874)
Poly [ADP-ribose] polymerase 1 (PARP-1) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 1) (ARTD1) (DNA ADP-ribosyltransferase PARP1) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 1) (ADPRT 1) (Poly[ADP-ribose] synthase 1) (Protein poly-ADP-ribosyltransferase PARP1) (EC 2.4.2.-) [Cleaved into: Poly [ADP-ribose] polymerase 1, processed C-terminus (Poly [ADP-ribose] polymerase 1, 89-kDa form); Poly [ADP-ribose] polymerase 1, processed N-terminus (NT-PARP-1) (Poly [ADP-ribose] polymerase 1, 24-kDa form) (Poly [ADP-ribose] polymerase 1, 28-kDa form)]
Gene: PARP1

Interactor 2: SMRC2 (Q8TAQ2)
SWI/SNF complex subunit SMARCC2 (BRG1-associated factor 170) (BAF170) (SWI/SNF complex 170 kDa subunit) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 2)
Gene: SMARCC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	34079125, 35271311
Identification Methods	proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000785 - chromatin GO:0005654 - nucleoplasm GO:0032991 - protein-containing complex GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 1014 Hs			1 1214
+	Hs
		455727 PARP1_HUMAN (1-1014): 0: 1362: 100.00		SMRC1_HUMAN (4-1082): 0: 957: 60.83
+	Hs
		455538 PARP1_HUMAN (1-1014): 0: 1362: 100.00		MYSM1_HUMAN (276-523): 7.61e-53: 202: 22.96
+	Hs
		455255 PARP1_HUMAN (1-1014): 0: 1362: 100.00		SC24C_HUMAN (1005-1213): 5.27e-13: 75.8: 19.28
+	Hs
		302243 PARP1_HUMAN (1-1014): 0: 1362: 100.00		SC31A_HUMAN (741-1068): 3.97e-10: 66.6: 9.06
+	Hs
		1188590 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		SMRC2_HUMAN (1-1203): 0: 992: 100.00
+	Hs
		1188660 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		SMRC1_HUMAN (4-1082): 0: 957: 60.83
+	Hs
		232275 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		KDM1A_HUMAN (253-543): 1.97e-43: 173: 15.00
+	Hs
		1189126 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		NCOR2_HUMAN (588-1208): 2.06e-32: 139: 14.22
+	Hs
		261537 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		NCOR1_HUMAN (597-1154): 8.84e-32: 137: 10.86
+	Hs
		1188963 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		OGFR_HUMAN (804-1190): 3.3e-13: 76.2: 16.02
+	Hs
		1188580 PARPT_HUMAN (710-1006): 4.56e-65: 234: 15.84		KMT2C_HUMAN (650-1128): 8.15e-09: 62.4: 8.57