Protein: PARP2
Poly [ADP-ribose] polymerase 2 (PARP-2) (hPARP-2) (EC 2.4.2.30) (ADP-ribosyltransferase diphtheria toxin-like 2) (ARTD2) (DNA ADP-ribosyltransferase PARP2) (EC 2.4.2.-) (NAD(+) ADP-ribosyltransferase 2) (ADPRT-2) (Poly[ADP-ribose] synthase 2) (pADPRT-2) (Protein poly-ADP-ribosyltransferase PARP2) (EC 2.4.2.-)

Gene: PARP2
Organism: Homo sapiens
Interactions: 157
UniProt ID: Q9UGN5

Gene Ontology (top 5):
GO:0003684 - damaged DNA binding
GO:0003682 - chromatin binding
GO:0003950 - NAD+ poly-ADP-ribosyltransferase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

487853

PARP1
Poly [ADP-ribose] polymerase 1

3

13

Small-scale

0.839

High

1451569

HPF1
Histone PARylation factor 1

2

1

Small-scale

0.812

High

892641

DNLI3
DNA ligase 3

2

2

High-throughput

0.776

High

1449658

RN146
E3 ubiquitin-protein ligase RNF146

6

3

Small-scale

0.727

High

1309441

APLF
Aprataxin and PNK-like factor

5

3

Small-scale

0.709

High

998914

H31
Histone H3.1

4

12

Small-scale

0.689

High

1292520

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

3

13

Small-scale

0.675

High

446549

DPOLB
DNA polymerase beta

3

1

High-throughput

0.667

High

589956

RFA2
Replication protein A 32 kDa subunit

3

4

High-throughput

0.667

High

1096848

RFA4
Replication protein A 30 kDa subunit

3

4

High-throughput

0.667

High

1381879

H2B1A
Histone H2B type 1-A

3

17

High-throughput

0.667

High

426590

HMGN2
Non-histone chromosomal protein HMG-17

3

3

Small-scale

0.662

High

558469

XRCC6
X-ray repair cross-complementing protein 6

3

5

High-throughput

0.662

High

1017274

H33
Histone H3.3

3

12

Small-scale

0.660

High

981162

H2B1C
Histone H2B type 1-C/E/F/G/I

3

17

Small-scale

0.646

High

980489

H4
Histone H4

3

2

High-throughput

0.640

High

1409758

SPI2B
Spindlin-2B

3

0

High-throughput

0.638

High

591874

H2AX
Histone H2AX

2

15

High-throughput

0.628

High

868397

CDX1
Homeobox protein CDX-1

2

3

High-throughput

0.628

High

1032882

XPC
DNA repair protein complementing XP-C cells

2

1

High-throughput

0.628

High

1086192

CETN1
Centrin-1

2

2

High-throughput

0.628

High

1289688

NAA40
N-alpha-acetyltransferase 40

2

1

High-throughput

0.628

High

1410178

MACD1
ADP-ribose glycohydrolase MACROD1

2

6

High-throughput

0.628

High

1453890

H2AW
Core histone macro-H2A.2

2

19

High-throughput

0.628

High

419257

H2A1B
Histone H2A type 1-B/E

2

13

High-throughput

0.611

High

1329927

SIR6
NAD-dependent protein deacylase sirtuin-6

2

3

High-throughput

0.611

High

591388

CD44
CD44 antigen

2

0

High-throughput

0.602

High

601894

HMGA1
High mobility group protein HMG-I/HMG-Y

2

1

High-throughput

0.601

High

1331922

DTX3
Probable E3 ubiquitin-protein ligase DTX3

2

3

High-throughput

0.601

High

1315260

CA174
UPF0688 protein C1orf174

2

0

High-throughput

0.576

High

616819

SDC1
Syndecan-1

2

2

High-throughput

0.574

High

760509

SDC2
Syndecan-2

2

2

High-throughput

0.574

High

397147

ESR1
Estrogen receptor

2

8

High-throughput

0.571

High

931149

HSP72
Heat shock-related 70 kDa protein 2

1

2

Small-scale

0.561

High

1053166

STP2
Nuclear transition protein 2

1

0

Small-scale

0.537

High

137492

HMGN4
High mobility group nucleosome-binding domain-containing protein 4

1

3

High-throughput

0.536

High

166202

AIM2
Interferon-inducible protein AIM2

1

3

High-throughput

0.536

High

216556

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

2

High-throughput

0.536

High

424469

HMGN1
Non-histone chromosomal protein HMG-14

1

1

High-throughput

0.536

High

502164

H2AZ
Histone H2A.Z

1

15

High-throughput

0.536

High

502581

H2A1
Histone H2A type 1

1

13

High-throughput

0.536

High

603693

JUNB
Transcription factor JunB

1

1

High-throughput

0.536

High

915492

HMGA2
High mobility group protein HMGI-C

1

3

High-throughput

0.536

High

939912

DLX6
Homeobox protein DLX-6

1

6

High-throughput

0.536

High

946033

VSX2
Visual system homeobox 2

1

2

High-throughput

0.536

High

1013117

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

2

High-throughput

0.536

High

1048230

EMX2
Homeobox protein EMX2

1

5

High-throughput

0.536

High

1134758

NUMA1
Nuclear mitotic apparatus protein 1

1

4

High-throughput

0.536

High

1162918

H2A2C
Histone H2A type 2-C

1

13

High-throughput

0.536

High

1163265

H2B2E
Histone H2B type 2-E

1

17

High-throughput

0.536

High

1232740

H2A2A
Histone H2A type 2-A

1

13

High-throughput

0.536

High

1235557

IFIX
Pyrin and HIN domain-containing protein 1

1

3

High-throughput

0.536

High

1278829

HDGR2
Hepatoma-derived growth factor-related protein 2

1

12

High-throughput

0.536

High

1323996

H2B3B
Histone H2B type 3-B

1

17

High-throughput

0.536

High

1407769

FOXB1
Forkhead box protein B1

1

3

High-throughput

0.536

High

1432946

UN45A
Protein unc-45 homolog A

1

5

High-throughput

0.536

High

1436818

WDR76
WD repeat-containing protein 76

1

6

High-throughput

0.536

High

1446805

LHX9
LIM/homeobox protein Lhx9

1

1

High-throughput

0.536

High

1446889

TF7L2
Transcription factor 7-like 2

1

10

High-throughput

0.536

High

290781

SURF6
Surfeit locus protein 6

1

0

High-throughput

0.513

High

1313179

ZC3H3
Zinc finger CCCH domain-containing protein 3

1

0

High-throughput

0.513

High

1385470

ZN707
Zinc finger protein 707

1

0

High-throughput

0.513

High

1390652

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.513

High

455885

H10
Histone H1.0

1

1

Small-scale

0.501

High

508780

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

High-throughput

0.501

High

595629

H15
Histone H1.5

1

7

Small-scale

0.501

High

1162071

H31T
Histone H3.1t

1

12

Small-scale

0.501

High

726704

SDC4
Syndecan-4

1

2

High-throughput

0.489

High

1091728

MYO1E
Unconventional myosin-Ie

1

3

High-throughput

0.489

High

1459603

CTNA3
Catenin alpha-3

1

1

High-throughput

0.489

High

1404632

STAC
SH3 and cysteine-rich domain-containing protein

1

5

Small-scale

0.484

High

373408

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.479

High

504994

H2AB2
Histone H2A-Bbd type 2/3

1

13

High-throughput

0.479

High

617750

XRCC1
DNA repair protein XRCC1

1

1

Small-scale

0.479

High

755019

H2B1B
Histone H2B type 1-B

1

17

High-throughput

0.479

High

851817

NKX21
Homeobox protein Nkx-2.1

1

6

High-throughput

0.479

High

853430

CBX5
Chromobox protein homolog 5

1

8

Small-scale

0.479

High

879582

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

4

High-throughput

0.479

High

913424

MSH6
DNA mismatch repair protein Msh6

1

6

High-throughput

0.479

High

937955

FOXA1
Hepatocyte nuclear factor 3-alpha

1

2

High-throughput

0.479

High

1100496

TIF1B
Transcription intermediary factor 1-beta

1

4

Small-scale

0.479

High

1110152

HDAC1
Histone deacetylase 1

1

8

High-throughput

0.479

High

1138139

TNIP1
TNFAIP3-interacting protein 1

1

3

High-throughput

0.479

High

1330966

CGAS
Cyclic GMP-AMP synthase

1

1

High-throughput

0.479

High

1367506

ESR2
Estrogen receptor beta

1

8

High-throughput

0.479

High

1403668

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

6

Small-scale

0.479

High

1446417

BRD7
Bromodomain-containing protein 7

1

6

High-throughput

0.479

High

1447394

ANLN
Anillin

1

2

High-throughput

0.479

High

1449243

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

1459192

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1026919

FKBP3
Peptidyl-prolyl cis-trans isomerase FKBP3

1

0

Small-scale

0.464

High

1032062

TFAP4
Transcription factor AP-4

1

0

Small-scale

0.458

High

1289803

SHLD2
Shieldin complex subunit 2

1

0

High-throughput

0.458

High

1431334

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

1448531

DISC1
Disrupted in schizophrenia 1 protein

1

2

High-throughput

0.457

High

63272

VP37C
Vacuolar protein sorting-associated protein 37C

1

3

Small-scale

0.445

High

176278

SYNJ2
Synaptojanin-2

1

1

Small-scale

0.445

High

208412

RRP8
Ribosomal RNA-processing protein 8

1

1

High-throughput

0.445

High

288809

NPM3
Nucleoplasmin-3

1

2

High-throughput

0.445

High

401655

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

3

High-throughput

0.445

High

521994

H14
Histone H1.4

1

6

Small-scale

0.445

High

765090

CTNB1
Catenin beta-1

1

5

Small-scale

0.445

High

903049

ZNF83
Zinc finger protein 83

1

1

Small-scale

0.445

High

962918

NCALD
Neurocalcin-delta

1

2

Small-scale

0.445

High

969504

RS8
Small ribosomal subunit protein eS8

1

1

High-throughput

0.445

High

1065478

SSRP1
FACT complex subunit SSRP1

1

9

High-throughput

0.445

High

1238527

PP4R4
Serine/threonine-protein phosphatase 4 regulatory subunit 4

1

2

Small-scale

0.445

High

1324768

S35F6
Solute carrier family 35 member F6

1

2

Small-scale

0.445

High

1352461

UTP15
U3 small nucleolar RNA-associated protein 15 homolog

1

4

Small-scale

0.445

High

1361592

ING5
Inhibitor of growth protein 5

1

4

Small-scale

0.445

High

1413329

DIDO1
Death-inducer obliterator 1

1

12

Small-scale

0.445

High

1453272

GRHL1
Grainyhead-like protein 1 homolog

1

2

High-throughput

0.445

High

1459602

DDX20
Probable ATP-dependent RNA helicase DDX20

1

2

Small-scale

0.445

High

1459604

AGO1
Protein argonaute-1

1

1

Small-scale

0.445

High

1459605

CERT
Ceramide transfer protein

1

2

Small-scale

0.445

High

1459607

ZHX2
Zinc fingers and homeoboxes protein 2

1

2

Small-scale

0.445

High

963474

STXB1
Syntaxin-binding protein 1

1

0

High-throughput

0.438

High

106797

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

1255959

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

303054

DFFB
DNA fragmentation factor subunit beta

1

0

Small-scale

0.426

High

425858

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

0

Small-scale

0.426

High

635807

PTMS
Parathymosin

1

0

Small-scale

0.426

High

1136877

MO4L2
Mortality factor 4-like protein 2

1

0

High-throughput

0.426

High

1278456

HAUS6
HAUS augmin-like complex subunit 6

1

0

Small-scale

0.426

High

1335041

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.426

High

1416345

CDCA7
Cell division cycle-associated protein 7

1

0

Small-scale

0.426

High

1432889

TPK1
Thiamine pyrophosphokinase 1

1

0

Small-scale

0.426

High

318413

MYO1D
Unconventional myosin-Id

1

3

Small-scale

0.407

High

329027

RTN3
Reticulon-3

1

1

Small-scale

0.407

High

755517

ERD22
ER lumen protein-retaining receptor 2

1

1

Small-scale

0.407

High

1228819

ANKS6
Ankyrin repeat and SAM domain-containing protein 6

1

5

Small-scale

0.407

High

1277092

PRIC2
Prickle-like protein 2

1

3

Small-scale

0.407

High

1307212

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

4

Small-scale

0.407

High

1331165

ZN321
Putative protein ZNF321

1

2

Small-scale

0.407

High

1413922

CRDL1
Chordin-like protein 1

1

2

Small-scale

0.407

High

1415064

ZN747
Zinc finger protein 747

1

1

Small-scale

0.407

High

1384093

ZN428
Zinc finger protein 428

2

0

High-throughput

0.328

High

1013350

HTRA4
Serine protease HTRA4

1

0

High-throughput

0.279

Low

50359

F168B
Myelin-associated neurite-outgrowth inhibitor

1

0

Small-scale

0.232

Low

137840

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

Small-scale

0.232

Low

420266

IFN16
Interferon alpha-16

1

0

Small-scale

0.232

Low

619319

LFA3
Lymphocyte function-associated antigen 3

1

0

Small-scale

0.232

Low

893539

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

0

Small-scale

0.232

Low

1127622

HABP2
Factor VII-activating protease

1

0

Small-scale

0.232

Low

1214137

DIK1A
Divergent protein kinase domain 1A

1

0

Small-scale

0.232

Low

1219961

FHI2A
FHF complex subunit HOOK interacting protein 2A

1

0

Small-scale

0.232

Low

1314891

LAS2
Lung adenoma susceptibility protein 2

1

0

Small-scale

0.232

Low

1315419

ASTRC
Protein Aster-C

1

0

Small-scale

0.232

Low

1328416

CCD33
Coiled-coil domain-containing protein 33

1

0

Small-scale

0.232

Low

1339963

OR4D6
Olfactory receptor 4D6

1

0

Small-scale

0.232

Low

1356632

CT55
Cancer/testis antigen 55

1

0

Small-scale

0.232

Low

1357806

CC107
Coiled-coil domain-containing protein 107

1

0

Small-scale

0.232

Low

1384229

LDAF1
Lipid droplet assembly factor 1

1

0

Small-scale

0.232

Low

1416624

TM2D2
TM2 domain-containing protein 2

1

0

Small-scale

0.232

Low

1417276

TMM59
Transmembrane protein 59

1

0

Small-scale

0.232

Low

1438142

IL21
Interleukin-21

1

0

Small-scale

0.232

Low

1459606

TEST
Testisin

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025