Interactor 1: CSF1R (P07333)
Macrophage colony-stimulating factor 1 receptor (CSF-1 receptor) (CSF-1-R) (CSF-1R) (M-CSF-R) (EC 2.7.10.1) (Proto-oncogene c-Fms) (CD antigen CD115)
Gene: CSF1R
Interactor 2: CSF1 (P09603)
Macrophage colony-stimulating factor 1 (CSF-1) (M-CSF) (MCSF) (Lanimostim) (Proteoglycan macrophage colony-stimulating factor) (PG-M-CSF) [Cleaved into: Processed macrophage colony-stimulating factor 1; Macrophage colony-stimulating factor 1 43 kDa subunit]
Gene: CSF1
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.88 | 1.00 | 0.939 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 8355686, 22483114, 22153499, 26235028, 22902366 |
| Identification Methods | pull down, isothermal titration calorimetry, field flow fractionation, bio-layer interferometry, x-ray crystallography, transmission electron microscopy, molecular sieving, light scattering, x ray scattering |
| Interaction Type | direct interaction |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | CSF-1~ig |
| Common GO terms | GO:0002931 - response to ischemia GO:0005886 - plasma membrane GO:0006954 - inflammatory response GO:0007169 - cell surface receptor protein tyrosine kinase signaling pathway GO:0008284 - positive regulation of cell population proliferation and 10 others more... |
| Homologous interactions | 3 |
Homologous interactions
Color coding for hit scores 
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
