HitPredict

Interactor 1: UCHL1 (P09936)
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCH-L1) (EC 3.4.19.12) (Neuron cytoplasmic protein 9.5) (PGP 9.5) (PGP9.5) (Ubiquitin thioesterase L1)
Gene: UCHL1

Interactor 2: UBP21 (Q9UK80)
Ubiquitin carboxyl-terminal hydrolase 21 (EC 3.4.19.12) (Deubiquitinating enzyme 21) (Ubiquitin thioesterase 21) (Ubiquitin-specific-processing protease 21)
Gene: USP21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.73 0.60 0.662

The method score is based on:

Property Details
Experiments 19615732, 22626734, 32814053
Identification Methods affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0004843 - cysteine-type deubiquitinase activity
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 223
Hs

1 565
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024