Protein: ANXA5
Annexin A5 (Anchorin CII) (Annexin V) (Annexin-5) (Calphobindin I) (CPB-I) (Endonexin II) (Lipocortin V) (Placental anticoagulant protein 4) (PP4) (Placental anticoagulant protein I) (PAP-I) (Thromboplastin inhibitor) (Vascular anticoagulant-alpha) (VAC-alpha)

Gene: ANXA5
Organism: Homo sapiens
Interactions: 185
UniProt ID: P08758

Gene Ontology (top 5):
GO:0001786 - phosphatidylserine binding
GO:0004859 - phospholipase inhibitor activity
GO:0005509 - calcium ion binding
GO:0005543 - phospholipid binding
GO:0005544 - calcium-dependent phospholipid binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

476176

LRC15
Leucine-rich repeat-containing protein 15

3

0

High-throughput

0.629

High

456574

ANXA2
Annexin A2

1

7

High-throughput

0.618

High

476201

CRNN
Cornulin

1

12

High-throughput

0.618

High

476071

CFTR
Cystic fibrosis transmembrane conductance regulator

2

4

Small-scale

0.611

High

400155

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

8

High-throughput

0.584

High

476097

PDIA3
Protein disulfide-isomerase A3

2

5

High-throughput

0.584

High

476114

YAP1
Transcriptional coactivator YAP1

2

14

High-throughput

0.584

High

476123

TERA
Transitional endoplasmic reticulum ATPase

2

7

High-throughput

0.584

High

476146

DX39B
Spliceosome RNA helicase DDX39B

2

4

High-throughput

0.584

High

476068

FGR
Tyrosine-protein kinase Fgr

2

1

High-throughput

0.571

High

476069

TAU
Microtubule-associated protein tau

2

5

Small-scale

0.571

High

476130

RAC1
Ras-related C3 botulinum toxin substrate 1

2

7

High-throughput

0.571

High

476150

KPCD1
Serine/threonine-protein kinase D1

2

6

High-throughput

0.571

High

476173

DOCK8
Dedicator of cytokinesis protein 8

2

4

High-throughput

0.571

High

476188

SH3G3
Endophilin-A3

2

4

High-throughput

0.571

High

476082

ITB5
Integrin beta-5

1

1

Small-scale

0.561

High

192357

GSC2
Homeobox protein goosecoid-2

2

1

High-throughput

0.553

High

476122

TERF1
Telomeric repeat-binding factor 1

1

4

High-throughput

0.552

High

476199

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

2

High-throughput

0.552

High

161934

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

7

High-throughput

0.536

High

180669

TIF1A
Transcription intermediary factor 1-alpha

1

16

High-throughput

0.536

High

213778

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

2

High-throughput

0.536

High

317394

KPCD3
Serine/threonine-protein kinase D3

1

6

High-throughput

0.536

High

362634

EGFR
Epidermal growth factor receptor

1

10

High-throughput

0.536

High

476077

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

4

High-throughput

0.536

High

476080

H2AX
Histone H2AX

1

7

High-throughput

0.536

High

476098

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

1

Small-scale

0.536

High

476112

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

3

High-throughput

0.536

High

476113

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

10

High-throughput

0.536

High

476154

MYLK
Myosin light chain kinase, smooth muscle

1

1

High-throughput

0.536

High

476175

NEK7
Serine/threonine-protein kinase Nek7

1

6

High-throughput

0.536

High

476180

SGK3
Serine/threonine-protein kinase Sgk3

1

5

High-throughput

0.536

High

476191

KPCD2
Serine/threonine-protein kinase D2

1

6

High-throughput

0.536

High

476104

VGFR2
Vascular endothelial growth factor receptor 2

1

1

Small-scale

0.527

High

476189

TINF2
TERF1-interacting nuclear factor 2

1

3

High-throughput

0.523

High

476105

FDFT
Squalene synthase

1

0

High-throughput

0.518

High

425267

ISG15
Ubiquitin-like protein ISG15

1

5

High-throughput

0.515

High

301308

WFS1
Wolframin

1

1

High-throughput

0.515

High

415287

HSPB1
Heat shock protein beta-1

1

3

High-throughput

0.515

High

476181

OPTN
Optineurin

1

14

High-throughput

0.515

High

476075

IRF2
Interferon regulatory factor 2

1

0

High-throughput

0.513

High

476086

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.513

High

476153

TERF2
Telomeric repeat-binding factor 2

1

4

High-throughput

0.504

High

384233

CO2A1
Collagen alpha-1(II) chain

1

4

Small-scale

0.501

High

421349

A4
Amyloid-beta precursor protein

1

3

High-throughput

0.501

High

476134

COAA1

1

5

Small-scale

0.501

High

178464

TBX3
T-box transcription factor TBX3

1

0

High-throughput

0.493

High

476174

OR1M1
Olfactory receptor 1M1

1

0

High-throughput

0.493

High

476185

LMTK3
Serine/threonine-protein kinase LMTK3

1

8

High-throughput

0.489

High

476195

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

4

High-throughput

0.489

High

476107

INGR2
Interferon gamma receptor 2

1

1

Small-scale

0.483

High

123317

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

1

High-throughput

0.479

High

127254

LEG8
Galectin-8

1

10

Small-scale

0.479

High

179124

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

1

Small-scale

0.479

High

227326

SPOP
Speckle-type POZ protein

1

3

High-throughput

0.479

High

239683

PCDH7
Protocadherin-7

1

2

High-throughput

0.479

High

258059

IF2P
Eukaryotic translation initiation factor 5B

1

1

High-throughput

0.479

High

271216

CPNE3
Copine-3

1

3

High-throughput

0.479

High

279619

CISY
Citrate synthase, mitochondrial

1

4

High-throughput

0.479

High

298288

DNJC8
DnaJ homolog subfamily C member 8

1

1

High-throughput

0.479

High

302333

RNF8
E3 ubiquitin-protein ligase RNF8

1

9

High-throughput

0.479

High

323118

TRI37
E3 ubiquitin-protein ligase TRIM37

1

15

High-throughput

0.479

High

347481

BAG3
BAG family molecular chaperone regulator 3

1

4

High-throughput

0.479

High

352871

AGR2
Anterior gradient protein 2 homolog

1

5

High-throughput

0.479

High

361069

SODC
Superoxide dismutase [Cu-Zn]

1

3

High-throughput

0.479

High

365274

PGK1
Phosphoglycerate kinase 1

1

2

High-throughput

0.479

High

370978

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.479

High

411221

NTRK1
High affinity nerve growth factor receptor

1

5

High-throughput

0.479

High

439624

INSR
Insulin receptor

1

9

High-throughput

0.479

High

476070

MYH1
Myosin-1

1

3

High-throughput

0.479

High

476073

PLST
Plastin-3

1

3

High-throughput

0.479

High

476076

ENPL
Endoplasmin

1

5

High-throughput

0.479

High

476079

TIMP2
Metalloproteinase inhibitor 2

1

2

High-throughput

0.479

High

476083

PGAM1
Phosphoglycerate mutase 1

1

2

High-throughput

0.479

High

476084

RO52
E3 ubiquitin-protein ligase TRIM21

1

5

High-throughput

0.479

High

476087

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

6

High-throughput

0.479

High

476088

CDK2
Cyclin-dependent kinase 2

1

4

High-throughput

0.479

High

476089

TNR6
Tumor necrosis factor receptor superfamily member 6

1

1

High-throughput

0.479

High

476091

HMGB2
High mobility group protein B2

1

9

High-throughput

0.479

High

476093

CALR
Calreticulin

1

3

High-throughput

0.479

High

476094

TKT
Transketolase

1

3

High-throughput

0.479

High

476096

PEBP1
Phosphatidylethanolamine-binding protein 1

1

5

High-throughput

0.479

High

476102

FBN1
Fibrillin-1 [Cleaved into: Asprosin]

1

2

Small-scale

0.479

High

476106

BRCA1
Breast cancer type 1 susceptibility protein

1

9

High-throughput

0.479

High

476108

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

1

2

High-throughput

0.479

High

476109

MDHM
Malate dehydrogenase, mitochondrial

1

2

High-throughput

0.479

High

476110

CCNF
Cyclin-F

1

4

High-throughput

0.479

High

476115

PA24A
Cytosolic phospholipase A2

1

4

Small-scale

0.479

High

476116

SOX2
Transcription factor SOX-2

1

6

High-throughput

0.479

High

476117

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

2

High-throughput

0.479

High

476119

CDK7
Cyclin-dependent kinase 7

1

4

High-throughput

0.479

High

476120

MECP2
Methyl-CpG-binding protein 2

1

4

High-throughput

0.479

High

476126

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

4

High-throughput

0.479

High

476127

CH10
10 kDa heat shock protein, mitochondrial

1

2

High-throughput

0.479

High

476129

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

476132

BASP1
Brain acid soluble protein 1

1

1

High-throughput

0.479

High

476133

HSF1
Heat shock factor protein 1

1

3

High-throughput

0.479

High

476136

DHX9
ATP-dependent RNA helicase A

1

3

Small-scale

0.479

High

476138

FBLN3
EGF-containing fibulin-like extracellular matrix protein 1

1

5

Small-scale

0.479

High

476140

TRI26
Tripartite motif-containing protein 26

1

5

Small-scale

0.479

High

476141

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

4

High-throughput

0.479

High

476142

NFX1
Transcriptional repressor NF-X1

1

1

High-throughput

0.479

High

476143

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

1

High-throughput

0.479

High

476144

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

476145

CUL4A
Cullin-4A

1

11

High-throughput

0.479

High

476147

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

6

High-throughput

0.479

High

476148

CUL7
Cullin-7

1

2

High-throughput

0.479

High

476149

EMC2
ER membrane protein complex subunit 2

1

5

High-throughput

0.479

High

476151

IPYR
Inorganic pyrophosphatase

1

2

High-throughput

0.479

High

476157

TET5C
Terminal nucleotidyltransferase 5C

1

1

High-throughput

0.479

High

476158

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

476159

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.479

High

476161

SND1
Staphylococcal nuclease domain-containing protein 1

1

4

High-throughput

0.479

High

476163

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

10

High-throughput

0.479

High

476164

ARMC8
Armadillo repeat-containing protein 8

1

1

High-throughput

0.479

High

476167

RPTOR
Regulatory-associated protein of mTOR

1

4

High-throughput

0.479

High

476168

EMC5
ER membrane protein complex subunit 5

1

3

High-throughput

0.479

High

476169

EMC1
ER membrane protein complex subunit 1

1

3

High-throughput

0.479

High

476170

CGAS
Cyclic GMP-AMP synthase

1

2

High-throughput

0.479

High

476172

UN13C
Protein unc-13 homolog C

1

5

High-throughput

0.479

High

476177

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.479

High

476178

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

10

High-throughput

0.479

High

476179

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

1

2

High-throughput

0.479

High

476182

GCP3
Gamma-tubulin complex component 3

1

1

High-throughput

0.479

High

476183

ASB9
Ankyrin repeat and SOCS box protein 9

1

5

High-throughput

0.479

High

476190

DOCK9
Dedicator of cytokinesis protein 9

1

4

High-throughput

0.479

High

476192

DDX24
ATP-dependent RNA helicase DDX24

1

4

High-throughput

0.479

High

476194

NMRL1
NmrA-like family domain-containing protein 1

1

1

High-throughput

0.479

High

476196

ARGAL
Rho guanine nucleotide exchange factor 10-like protein

1

3

High-throughput

0.479

High

476200

PD1L1
Programmed cell death 1 ligand 1

1

6

Small-scale

0.479

High

476202

HDAC6
Protein deacetylase HDAC6

1

5

High-throughput

0.479

High

476204

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.479

High

476205

PA2G4
Proliferation-associated protein 2G4

1

2

High-throughput

0.479

High

476208

LAMC3
Laminin subunit gamma-3

1

0

High-throughput

0.460

High

143532

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

0

High-throughput

0.458

High

213046

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.458

High

223493

ZN207
BUB3-interacting and GLEBS motif-containing protein ZNF207

1

0

High-throughput

0.458

High

361840

HPRT
Hypoxanthine-guanine phosphoribosyltransferase

1

0

High-throughput

0.458

High

424336

HMGN1
Non-histone chromosomal protein HMG-14

1

0

High-throughput

0.458

High

446114

PYGL
Glycogen phosphorylase, liver form

1

0

High-throughput

0.458

High

446365

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.458

High

459411

PROF1
Profilin-1

1

0

High-throughput

0.458

High

476074

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.458

High

476081

STMN1
Stathmin

1

0

High-throughput

0.458

High

476085

PTMS
Parathymosin

1

0

High-throughput

0.458

High

476095

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

476125

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.458

High

476137

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.458

High

476156

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

0

High-throughput

0.458

High

476166

AGRF5
Adhesion G protein-coupled receptor F5

1

0

High-throughput

0.458

High

476186

PARK7
Parkinson disease protein 7

1

0

High-throughput

0.458

High

476187

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

476198

SIAS
N-acetylneuraminate-9-phosphate synthase

1

0

High-throughput

0.458

High

476203

ATIF1
ATPase inhibitor, mitochondrial

1

0

High-throughput

0.458

High

476206

WBP11
WW domain-binding protein 11

1

0

High-throughput

0.458

High

476135

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

1

High-throughput

0.457

High

476100

BMI1
Polycomb complex protein BMI-1

1

10

High-throughput

0.445

High

476124

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.445

High

476160

NEK10
Serine/threonine-protein kinase Nek10

1

5

High-throughput

0.445

High

476171

POC5
Centrosomal protein POC5

1

1

Small-scale

0.445

High

105163

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

259331

BRD4
Bromodomain-containing protein 4

1

5

High-throughput

0.437

High

276039

NIPS2
Protein NipSnap homolog 2

1

2

Small-scale

0.437

High

471759

RU2B
U2 small nuclear ribonucleoprotein B''

1

3

High-throughput

0.437

High

476072

PDIA4
Protein disulfide-isomerase A4

1

5

High-throughput

0.437

High

476078

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.437

High

476090

U2AF2
Splicing factor U2AF 65 kDa subunit

1

7

High-throughput

0.437

High

476092

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

476101

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

476103

FUS
RNA-binding protein FUS

1

3

High-throughput

0.437

High

476111

BCL6
B-cell lymphoma 6 protein

1

3

High-throughput

0.437

High

476128

SUMO2
Small ubiquitin-related modifier 2

1

6

High-throughput

0.437

High

476139

SF3A3
Splicing factor 3A subunit 3

1

1

High-throughput

0.437

High

476155

EZH2
Histone-lysine N-methyltransferase EZH2

1

5

High-throughput

0.437

High

476162

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

3

High-throughput

0.437

High

476165

TRI59
Tripartite motif-containing protein 59

1

8

Small-scale

0.437

High

476184

TIGD1
Tigger transposable element-derived protein 1

1

1

High-throughput

0.437

High

476193

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

2

High-throughput

0.437

High

476207

AAR2
Protein AAR2 homolog

1

2

High-throughput

0.437

High

476118

CEBPA
CCAAT/enhancer-binding protein alpha

1

9

High-throughput

0.373

High

476099

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.279

Low

476197

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

1

0

High-throughput

0.279

Low

476121

RM12
Large ribosomal subunit protein bL12m

1

0

High-throughput

0.249

Low

476152

SF3A1
Splicing factor 3A subunit 1

1

0

High-throughput

0.249

Low

476131

SPT4H
Transcription elongation factor SPT4

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025