HitPredict

Interactor 1: TRXB (P0A9P4)
Thioredoxin reductase (TRXR) (EC 1.8.1.9)
Gene: TRXB

Interactor 2: THIO (P0AA25)
Thioredoxin 1 (Trx-1)
Gene: trxA

Species: Escherichia coli K-12

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	1.00	0.800

Property	Details
Experiments	24561554, 10947986
Identification Methods	two hybrid, x-ray crystallography, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Pyr_redox_2~Thioredoxin
Common GO terms	GO:0005829 - cytosol GO:0045454 - cell redox homeostasis
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 321 Ec			1 109
+	At
		186687 TRXB3_ARATH (2-316): 2.33e-86: 270: 46.27		TRXY1_ARATH (9-108): 1.06e-36: 124: 39.00
+	Os
		1174198 NTRC_ORYSJ (3-314): 6.61e-86: 269: 45.14		TRXX_ORYSJ (5-109): 3.66e-35: 120: 39.25
+	At
		186690 TRXB3_ARATH (2-316): 2.33e-86: 270: 46.27		TRXX_ARATH (3-108): 3.37e-34: 117: 36.11
+	Sc
		606193 TRXB1_YEAST (6-318): 5.97e-85: 260: 47.53		TRX1_YEAST (9-107): 3.5e-34: 115: 40.40
+	Sc
		611711 TRXB1_YEAST (6-318): 5.97e-85: 260: 47.53		TRX2_YEAST (9-108): 7.6e-34: 114: 33.00
+	Cj
		1011632 Q0PBZ1_CAMJE (8-317): 1.63e-72: 228: 36.16		Q0PBZ0_CAMJE (3-108): 1.47e-38: 126: 45.28
+	Hs
		452782 DLDH_HUMAN (6-313): 2.45e-67: 220: 17.19		PDIA6_HUMAN (2-108): 3.32e-35: 126: 26.85
+	Ec
		465637 STHA_ECOLI (1-313): 4.52e-59: 198: 17.48		THIO_ECOLI (1-109): 2.99e-42: 136: 100.00
+	Hs
		1067720 TRXR1_HUMAN (17-321): 1.76e-59: 203: 16.34		PDIA6_HUMAN (2-108): 3.32e-35: 126: 26.85
+	Dm
		954892 TRXR1_DROME (2-321): 3.22e-79: 254: 14.60		THIO2_DROME (13-108): 6.76e-16: 68.9: 37.11
+	At
		1155146 Q8W4M1_ARATH (218-316): 1.7e-34: 127: 50.00		TRXY1_ARATH (9-108): 1.06e-36: 124: 39.00