HitPredict

Interactor 1: ACRA (P0AE06)
Multidrug efflux pump subunit AcrA (AcrAB-TolC multidrug efflux pump subunit AcrA) (Acridine resistance protein A)
Gene: ACRA

Interactor 2: ACRA (P0AE06)
Multidrug efflux pump subunit AcrA (AcrAB-TolC multidrug efflux pump subunit AcrA) (Acridine resistance protein A)
Gene: ACRA

Species: Escherichia coli K-12

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.927

The method score is based on:

Property	Details
Experiments	24561554, 16079137, 16531241, 19805313, 19254725
Identification Methods	two hybrid, blue native page, x-ray crystallography, surface plasmon resonance, cross-linking study, molecular sieving, two hybrid array
Interaction Type	direct interaction, physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	CusB_dom_1~CusB_dom_1, HlyD_D23~HlyD_D23
Common GO terms	GO:0015721 - bile acid and bile salt transport GO:0022857 - transmembrane transporter activity GO:0030288 - outer membrane-bounded periplasmic space GO:0042908 - xenobiotic transport GO:0046677 - response to antibiotic and 3 others more... GO:0098567 - periplasmic side of plasma membrane GO:0140330 - xenobiotic detoxification by transmembrane export across the cell outer membrane GO:1990281 - efflux pump complex
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	397
Ec

1	397

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024