HitPredict

Interactor 1: H2AZ (P0C0S5)
Histone H2A.Z (H2A/z)
Gene: H2AZ1

Interactor 2: CBX5 (P45973)
Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha)
Gene: CBX5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000792 - heterochromatin GO:0005634 - nucleus GO:0006325 - chromatin organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 128 Hs			1 191
+	Hs
		470011 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22
+	Hs
		800438 H2A3_HUMAN (5-125): 5.08e-55: 169: 62.30		CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00
+	Hs
		469996 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65
+	Hs
		594841 H2A1D_HUMAN (5-125): 7.06e-55: 169: 62.30		CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22
+	Hs
		949822 H2AV_HUMAN (1-127): 2.06e-60: 183: 98.43		CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65
+	Dm
		398981 H2AV_DROME (1-125): 2.57e-60: 183: 96.00		HP1_DROME (1-180): 3.46e-50: 162: 42.23
+	Hs
		391654 H2A1B_HUMAN (5-125): 9.18e-55: 169: 61.48		CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65
+	Hs
		594840 H2A1D_HUMAN (5-125): 7.06e-55: 169: 62.30		CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65
+	Hs
		470208 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		CDYL_HUMAN (6-159): 1.34e-34: 129: 22.84
+	Hs
		203730 H2A2B_HUMAN (5-127): 9.2e-56: 171: 59.68		SUV91_HUMAN (4-135): 2.04e-36: 132: 19.70
+	Hs
		203696 H2A2C_HUMAN (5-127): 3.47e-55: 170: 61.29		SUV91_HUMAN (4-135): 2.04e-36: 132: 19.70
+	Hs
		1087137 H2A2C_HUMAN (5-127): 3.47e-55: 170: 61.29		CDYL_HUMAN (6-159): 1.34e-34: 129: 22.84
+	Hs
		391975 H2A1B_HUMAN (5-125): 9.18e-55: 169: 61.48		CDYL_HUMAN (6-159): 1.34e-34: 129: 22.84
+	Hs
		470020 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		CBX2_HUMAN (10-111): 5.1e-24: 99.9: 31.37
+	Hs
		1312232 H2AJ_HUMAN (5-127): 8.35e-56: 171: 60.48		CBX8_HUMAN (11-132): 1.8e-29: 113: 25.41
+	Hs
		391912 H2A1B_HUMAN (5-125): 9.18e-55: 169: 61.48		CBX8_HUMAN (11-132): 1.8e-29: 113: 25.41
+	Hs
		123160 H2A1B_HUMAN (5-125): 9.18e-55: 169: 61.48		CBX4_HUMAN (11-125): 7.54e-26: 105: 25.22
+	Hs
		316082 H2A2B_HUMAN (5-127): 9.2e-56: 171: 59.68		CBX6_HUMAN (11-103): 2.2e-24: 100: 31.18
+	Hs
		315950 H2A1B_HUMAN (5-125): 9.18e-55: 169: 61.48		CBX6_HUMAN (11-103): 2.2e-24: 100: 31.18
+	Hs
		391702 H2A1B_HUMAN (5-125): 9.18e-55: 169: 61.48		CBX2_HUMAN (10-111): 5.1e-24: 99.9: 31.37