HitPredict

Interactor 1: VAV (P15498)
Proto-oncogene vav
Gene: VAV1

Interactor 2: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	8621483
Identification Methods	coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1_1~SH2, PH~SH3_1, RhoGEF~SH3_1, SH2~SH2, SH2~SH3_1, SH2~SH3_2, SH3_1~SH3_1, SH3_1~SH3_2
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016477 - cell migration and 1 others more... GO:0043087 - regulation of GTPase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 845 Hs			1 304
+	Hs
		548628 VAV_HUMAN (1-845): 0: 641: 100.00		VAV_HUMAN (11-189): 6.6e-47: 170: 28.21
+	Hs
		548634 VAV_HUMAN (1-845): 0: 641: 100.00		PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39
+	Hs
		548630 VAV_HUMAN (1-845): 0: 641: 100.00		PLCG2_HUMAN (1-301): 1.03e-25: 109: 15.89
+	Hs
		548677 VAV_HUMAN (1-845): 0: 641: 100.00		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Mm
		654982 VAV_MOUSE (1-845): 0: 634: 93.14		GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67
+	Hs
		924938 VAV3_HUMAN (1-840): 0: 601: 57.31		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		924777 Q96D37_HUMAN (66-845): 0: 588: 99.62		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Mm
		1141129 VAV2_MOUSE (1-839): 0: 572: 47.39		GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67
+	Hs
		855781 VAV2_HUMAN (1-839): 0: 562: 47.14		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		924658 FGD6_HUMAN (121-613): 1.98e-80: 285: 14.96		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		924870 ECT2_HUMAN (83-631): 2.68e-76: 268: 16.55		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		1078876 PREX1_HUMAN (146-543): 5.53e-76: 272: 21.53		ITSN1_HUMAN (150-302): 3.02e-10: 63.3: 13.87
+	Hs
		557795 ECT2_HUMAN (83-631): 2.68e-76: 268: 16.55		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		279897 TRIO_HUMAN (182-669): 1.27e-49: 193: 14.54		ITSN2_HUMAN (189-304): 5.82e-12: 68.3: 11.86
+	Rn
		499159 GRB2_RAT (787-838): 7.33e-15: 76.3: 48.08		PLCG1_RAT (8-302): 1.46e-26: 111: 15.72
+	Hs
		924563 ARHG7_HUMAN (756-843): 5.34e-15: 81.4: 27.27		GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67
+	Hs
		209051 ARHG7_HUMAN (756-843): 5.34e-15: 81.4: 27.27		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00
+	Hs
		557687 ARHG7_HUMAN (756-843): 5.34e-15: 81.4: 27.27		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00
+	Hs
		209055 ARHG6_HUMAN (732-843): 2.95e-14: 79.1: 23.21		NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00
+	Hs
		557698 ARHG6_HUMAN (732-843): 2.95e-14: 79.1: 23.21		NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00