HitPredict

Interactor 1: H2AZ (P0C0S5)
Histone H2A.Z (H2A/z)
Gene: H2AZ1

Interactor 2: CENPA (P49450)
Histone H3-like centromeric protein A (Centromere autoantigen A) (Centromere protein A) (CENP-A)
Gene: CENPA

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	34079125, 16622419
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Histone~Histone, Histone~Histone_H2A_C
Common GO terms	GO:0000786 - nucleosome GO:0005634 - nucleus GO:0030527 - structural constituent of chromatin GO:0046982 - protein heterodimerization activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 128 Hs			1 140
+	Hs
		469993 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		H31_HUMAN (5-134): 1.29e-52: 164: 48.86
+	Mm
		470229 H2AZ_MOUSE (1-128): 9.79e-62: 186: 100.00		H31_MOUSE (5-134): 1.29e-52: 164: 48.86
+	Hs
		470036 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		H31T_HUMAN (5-134): 1.01e-51: 162: 48.09
+	Hs
		470061 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		H32_HUMAN (5-134): 1.73e-51: 161: 48.86
+	Mm
		470230 H2AZ_MOUSE (1-128): 9.79e-62: 186: 100.00		H32_MOUSE (5-134): 1.73e-51: 161: 48.86
+	Mm
		470231 H2AZ_MOUSE (1-128): 9.79e-62: 186: 100.00		H33_MOUSE (5-134): 1.57e-51: 161: 49.62
+	Hs
		934914 H2AV_HUMAN (1-127): 2.06e-60: 183: 98.43		H31_HUMAN (5-134): 1.29e-52: 164: 48.86
+	Hs
		1086191 H2AV_HUMAN (1-127): 2.06e-60: 183: 98.43		H31T_HUMAN (5-134): 1.01e-51: 162: 48.09
+	Hs
		1157204 H2AV_HUMAN (1-127): 2.06e-60: 183: 98.43		H3C_HUMAN (5-134): 5.15e-52: 162: 47.69
+	Hs
		935141 H2A1A_HUMAN (5-125): 2.16e-56: 173: 61.48		H31_HUMAN (5-134): 1.29e-52: 164: 48.86
+	Hs
		934946 H2A2B_HUMAN (5-127): 9.2e-56: 171: 59.68		H31_HUMAN (5-134): 1.29e-52: 164: 48.86
+	Hs
		935170 H2A1J_HUMAN (5-125): 1.24e-55: 171: 61.48		H31_HUMAN (5-134): 1.29e-52: 164: 48.86
+	Mm
		935458 Q8CGP4_MOUSE (5-127): 1.37e-55: 171: 59.68		H31_MOUSE (5-134): 1.29e-52: 164: 48.86
+	Hs
		1086203 H2A2B_HUMAN (5-127): 9.2e-56: 171: 59.68		H31T_HUMAN (5-134): 1.01e-51: 162: 48.09
+	Hs
		1086293 H2A1J_HUMAN (5-125): 1.24e-55: 171: 61.48		H31T_HUMAN (5-134): 1.01e-51: 162: 48.09
+	Hs
		1157222 H2A1J_HUMAN (5-125): 1.24e-55: 171: 61.48		H3C_HUMAN (5-134): 5.15e-52: 162: 47.69
+	Hs
		1174640 H2A1J_HUMAN (5-125): 1.24e-55: 171: 61.48		H32_HUMAN (5-134): 1.73e-51: 161: 48.86
+	Mm
		952264 Q8CGP4_MOUSE (5-127): 1.37e-55: 171: 59.68		H32_MOUSE (5-134): 1.73e-51: 161: 48.86
+	Hs
		952450 H2A2B_HUMAN (5-127): 9.2e-56: 171: 59.68		H33_HUMAN (5-134): 1.57e-51: 161: 49.62
+	Mm
		952759 Q8CGP4_MOUSE (5-127): 1.37e-55: 171: 59.68		H33_MOUSE (5-134): 1.57e-51: 161: 49.62