Protein: KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17)

Gene: KCC2A, Camk2a
Organism: Rattus norvegicus
Interactions: 123
UniProt ID: P11275

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0002931 - response to ischemia
GO:0004674 - protein serine/threonine kinase activity
GO:0004683 - calcium/calmodulin-dependent protein kinase activity
GO:0005516 - calmodulin binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

540144

LRRC7
Leucine-rich repeat-containing protein 7

2

3

Small-scale

0.825

High

470382

ACM4
Muscarinic acetylcholine receptor M4

1

3

Small-scale

0.757

High

92872

D3ZCV0
F-actin cross-linking protein

1

6

Small-scale

0.724

High

73535

BRSK1
Serine/threonine-protein kinase BRSK1

1

8

High-throughput

0.618

High

73560

UBL4A
Ubiquitin-like protein 4A

1

9

High-throughput

0.618

High

98622

F1LSE6
PTPRF interacting protein alpha 3

1

3

High-throughput

0.618

High

312410

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

1

8

High-throughput

0.618

High

469961

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

16

High-throughput

0.618

High

540120

GSK3B
Glycogen synthase kinase-3 beta

1

4

High-throughput

0.618

High

540132

DGKG
Diacylglycerol kinase gamma

1

2

High-throughput

0.618

High

540133

DGKB
Diacylglycerol kinase beta

1

7

High-throughput

0.618

High

540139

RAN
GTP-binding nuclear protein Ran

1

2

High-throughput

0.618

High

540140

DNJA1
DnaJ homolog subfamily A member 1

1

1

High-throughput

0.618

High

540141

KPCG
Protein kinase C gamma type

1

7

High-throughput

0.618

High

540142

KPCB
Protein kinase C beta type

1

5

High-throughput

0.618

High

540150

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

13

High-throughput

0.618

High

540154

CTTB2
Cortactin-binding protein 2

1

2

High-throughput

0.618

High

540163

Q5M9H7
DnaJ homolog subfamily A member 2

1

1

High-throughput

0.618

High

540164

DCLK2
Serine/threonine-protein kinase DCLK2

1

15

High-throughput

0.618

High

540168

RHEB
GTP-binding protein Rheb

1

2

High-throughput

0.618

High

540172

ROCK2
Rho-associated protein kinase 2

1

2

High-throughput

0.618

High

540175

CAMKV
CaM kinase-like vesicle-associated protein

1

15

High-throughput

0.618

High

540177

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin; Ubiquitin-related]

1

9

High-throughput

0.618

High

540182

CDC37
Hsp90 co-chaperone Cdc37

1

3

High-throughput

0.618

High

540189

TANC1
Protein TANC1

1

2

Small-scale

0.618

High

540190

BAG6
Large proline-rich protein BAG6

1

6

High-throughput

0.618

High

540193

PPM1E
Protein phosphatase 1E

1

5

High-throughput

0.618

High

540194

AGAP2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

1

8

High-throughput

0.618

High

540195

CSKI1
Caskin-1

1

5

High-throughput

0.618

High

540199

RGRF2
Ras-specific guanine nucleotide-releasing factor 2

1

3

High-throughput

0.618

High

540210

ACTN1
Alpha-actinin-1

1

6

Small-scale

0.618

High

540211

CNKR2
Connector enhancer of kinase suppressor of ras 2

1

11

High-throughput

0.618

High

540212

GIT1
ARF GTPase-activating protein GIT1

1

8

High-throughput

0.618

High

540138

PRS8
26S proteasome regulatory subunit 8

2

3

Small-scale

0.595

High

540174

ARC
Activity-regulated cytoskeleton-associated protein

2

2

Small-scale

0.595

High

540128

RAB8A
Ras-related protein Rab-8A

1

0

High-throughput

0.586

High

540170

CAPS1
Calcium-dependent secretion activator 1

1

0

High-throughput

0.586

High

540188

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.586

High

540147

NMDE1
Glutamate receptor ionotropic, NMDA 2A

2

16

Small-scale

0.584

High

540148

NMDE2
Glutamate receptor ionotropic, NMDA 2B

2

16

Small-scale

0.584

High

540169

DLG1
Disks large homolog 1

1

15

Small-scale

0.578

High

470381

ACM3
Muscarinic acetylcholine receptor M3

1

3

Small-scale

0.575

High

540158

RD23B
UV excision repair protein RAD23 homolog B

1

3

Small-scale

0.575

High

540122

GRIA1
Glutamate receptor 1

2

8

Small-scale

0.563

High

540167

ITM2B
Integral membrane protein 2B

1

7

High-throughput

0.536

High

540134

CAC1A
Voltage-dependent P/Q-type calcium channel subunit alpha-1A

1

7

Small-scale

0.515

High

267287

CXD2
Gap junction delta-2 protein

1

1

Small-scale

0.501

High

540119

PSA2
Proteasome subunit alpha type-2

1

1

Small-scale

0.501

High

540125

GRM2
Metabotropic glutamate receptor 2

1

6

Small-scale

0.481

High

540126

GRM3
Metabotropic glutamate receptor 3

1

6

Small-scale

0.481

High

148533

LBR
Delta(14)-sterol reductase LBR

1

0

Small-scale

0.480

High

98609

RHG44
Rho GTPase-activating protein 44

1

7

High-throughput

0.479

High

98663

F1LST4
Microtubule-associated protein

1

14

High-throughput

0.479

High

98856

RPGF2
Rap guanine nucleotide exchange factor 2

1

2

High-throughput

0.479

High

108189

G3V8J5
Pleckstrin and Sec7 domain containing

1

4

High-throughput

0.479

High

204568

NEB2
Neurabin-2

1

20

Small-scale

0.479

High

204635

DNM1L
Dynamin-1-like protein

1

2

High-throughput

0.479

High

266829

TRIM3
Tripartite motif-containing protein 3

1

5

High-throughput

0.479

High

418771

GSTM1
Glutathione S-transferase Mu 1

1

1

High-throughput

0.479

High

504825

MAP1S
Microtubule-associated protein 1S

1

2

High-throughput

0.479

High

540116

PDE4D
3',5'-cyclic-AMP phosphodiesterase 4D

1

6

High-throughput

0.479

High

540117

PDE4B
3',5'-cyclic-AMP phosphodiesterase 4B

1

6

High-throughput

0.479

High

540127

GRM4
Metabotropic glutamate receptor 4

1

6

Small-scale

0.479

High

540129

GRM7
Metabotropic glutamate receptor 7

1

6

Small-scale

0.479

High

540135

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

5

High-throughput

0.479

High

540143

STRN
Striatin

1

8

High-throughput

0.479

High

540145

DLGP1
Disks large-associated protein 1

1

9

High-throughput

0.479

High

540146

DLGP4
Disks large-associated protein 4

1

9

High-throughput

0.479

High

540149

PDE2A
cGMP-dependent 3',5'-cyclic phosphodiesterase

1

6

High-throughput

0.479

High

540153

DREB
Drebrin

1

7

High-throughput

0.479

High

540159

SAM14
Sterile alpha motif domain-containing protein 14

1

8

High-throughput

0.479

High

540160

ARHG2
Rho guanine nucleotide exchange factor 2

1

7

High-throughput

0.479

High

540162

PI51C
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

1

2

High-throughput

0.479

High

540165

BAG5
BAG family molecular chaperone regulator 5

1

2

High-throughput

0.479

High

540166

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.479

High

540173

DLG3
Disks large homolog 3

1

15

High-throughput

0.479

High

540176

PRS7
26S proteasome regulatory subunit 7

1

3

Small-scale

0.479

High

540178

MAP6
Microtubule-associated protein 6

1

2

High-throughput

0.479

High

540179

PRS6A
26S proteasome regulatory subunit 6A

1

4

High-throughput

0.479

High

540181

HYOU1
Hypoxia up-regulated protein 1

1

3

High-throughput

0.479

High

540183

EHD1
EH domain-containing protein 1

1

1

High-throughput

0.479

High

540184

KCNJ2
Inward rectifier potassium channel 2

1

3

Small-scale

0.479

High

540185

AT1A4
Sodium/potassium-transporting ATPase subunit alpha-4

1

1

High-throughput

0.479

High

540186

HS105
Heat shock protein 105 kDa

1

3

High-throughput

0.479

High

540187

Q68G41
Enoyl-CoA delta isomerase 1, mitochondrial

1

3

High-throughput

0.479

High

540191

KIF5A
Kinesin heavy chain isoform 5A

1

3

High-throughput

0.479

High

540198

PEX5R
PEX5-related protein

1

7

High-throughput

0.479

High

540200

FUBP2
Far upstream element-binding protein 2

1

3

High-throughput

0.479

High

540201

WDR7
WD repeat-containing protein 7

1

2

High-throughput

0.479

High

540202

PCLO
Protein piccolo

1

8

High-throughput

0.479

High

540204

SRCN1
SRC kinase signaling inhibitor 1

1

4

High-throughput

0.479

High

540205

MYO5A
Unconventional myosin-Va

1

2

High-throughput

0.479

High

540207

PHOCN
MOB-like protein phocein

1

1

High-throughput

0.479

High

540209

E41L1
Band 4.1-like protein 1

1

7

High-throughput

0.479

High

148043

PI4KA
Phosphatidylinositol 4-kinase alpha

1

0

High-throughput

0.458

High

148453

MADD
MAP kinase-activating death domain protein

1

0

High-throughput

0.458

High

266913

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.458

High

540118

IP3KA
Inositol-trisphosphate 3-kinase A

1

0

High-throughput

0.458

High

540123

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.458

High

540124

TCPA
T-complex protein 1 subunit alpha

1

0

High-throughput

0.458

High

540130

PPAC
Low molecular weight phosphotyrosine protein phosphatase

1

0

High-throughput

0.458

High

540131

ASNS
Asparagine synthetase [glutamine-hydrolyzing]

1

0

High-throughput

0.458

High

540136

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

540137

PHAR1
Phosphatase and actin regulator 1

1

0

High-throughput

0.458

High

540151

BASP1
Brain acid soluble protein 1

1

0

Small-scale

0.458

High

540152

ADDB
Beta-adducin

1

0

High-throughput

0.458

High

540155

Q3MHT2
Cysteine desulfurase

1

0

High-throughput

0.458

High

540156

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.458

High

540161

IMPCT
Protein IMPACT

1

0

High-throughput

0.458

High

540171

INP4A
Inositol polyphosphate-4-phosphatase type I A

1

0

High-throughput

0.458

High

540180

TPM3
Tropomyosin alpha-3 chain

1

0

High-throughput

0.458

High

540192

IQEC3
IQ motif and SEC7 domain-containing protein 3

1

0

High-throughput

0.458

High

540196

ASGL1
Isoaspartyl peptidase/L-asparaginase

1

0

High-throughput

0.458

High

540197

ZWINT
Outer kinetochore KNL1 complex subunit ZWINT

1

0

High-throughput

0.458

High

540208

SEPT9
Septin-9

1

0

High-throughput

0.458

High

540121

TAU
Microtubule-associated protein tau

1

14

High-throughput

0.445

High

73547

CAZA1
F-actin-capping protein subunit alpha-1

1

2

High-throughput

0.437

High

92863

D3ZCL8
Synaptic Ras GTPase activating protein 1

1

11

High-throughput

0.437

High

540157

CAZA2
F-actin-capping protein subunit alpha-2

1

2

High-throughput

0.437

High

108211

G3V8V3
Alpha-1,4 glucan phosphorylase

1

0

High-throughput

0.249

Low

236694

EXOC8
Exocyst complex component 8

1

0

High-throughput

0.249

Low

540203

DCTN4
Dynactin subunit 4

1

0

High-throughput

0.249

Low

540206

NRBF2
Nuclear receptor-binding factor 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025