HitPredict

Interactor 1: H2AZ (P0C0S5)
Histone H2A.Z (H2A/z)
Gene: H2AZ1

Interactor 2: H4 (P62805)
Histone H4
Gene: H4C1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	1.00	0.935

Property	Details
Experiments	27248496, 35271311, 34349018, 37071682, 22493515, 24463511
Identification Methods	affinity chromatography technology, cross-linking study, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CENP-T_C~Histone, CENP-T_C~Histone_H2A_C
Common GO terms	GO:0000786 - nucleosome GO:0005634 - nucleus GO:0006325 - chromatin organization GO:0030527 - structural constituent of chromatin GO:0046982 - protein heterodimerization activity and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 128 Hs			1 103
+	Hs
		917485 H2AV_HUMAN (1-127): 2.06e-60: 183: 98.43		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Dm
		446313 H2AV_DROME (1-125): 2.57e-60: 183: 96.00		H4_DROME (1-103): 4.51e-48: 150: 99.03
+	Hs
		917544 H2A2B_HUMAN (5-127): 9.2e-56: 171: 59.68		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917817 H2A1J_HUMAN (5-125): 1.24e-55: 171: 61.48		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917354 H2A2C_HUMAN (5-127): 3.47e-55: 170: 61.29		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917757 H2A1H_HUMAN (5-125): 2.98e-55: 170: 61.48		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		391638 H2A1B_HUMAN (5-125): 9.18e-55: 169: 61.48		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		470324 H2A1_HUMAN (5-125): 8.23e-55: 169: 61.48		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		555395 H2AX_HUMAN (5-124): 1.08e-54: 169: 61.98		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		594838 H2A1D_HUMAN (5-125): 7.06e-55: 169: 62.30		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917438 H2A2A_HUMAN (5-125): 4.61e-55: 169: 62.30		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917496 H2A3_HUMAN (5-125): 5.08e-55: 169: 62.30		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917699 H2A1C_HUMAN (5-125): 5.99e-55: 169: 61.48		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		470137 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		H4G_HUMAN (1-98): 1.04e-38: 126: 84.69
+	Sc
		356810 H2AZ_YEAST (4-126): 3.32e-39: 129: 65.91		H4_YEAST (18-103): 6.13e-41: 132: 90.70