Protein: Q9W3X6
fumarate hydratase (EC 4.2.1.2)

Gene: Q9W3X6, Fum1
Organism: Drosophila melanogaster
Interactions: 173
UniProt ID: Q9W3X6

Gene Ontology (top 5):
GO:0004333 - fumarate hydratase activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006099 - tricarboxylic acid cycle
GO:0006106 - fumarate metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

653063

HMOC
Homeotic protein ocelliless

1

1

High-throughput

0.451

High

121367

ALDR
Aldo-keto reductase 1B

1

5

High-throughput

0.445

High

234810

O46067
Hypoxia up-regulated protein 1

1

3

High-throughput

0.445

High

477082

NDKA
Nucleoside diphosphate kinase

1

1

High-throughput

0.445

High

1019704

TRXR1
Thioredoxin reductase 1, mitochondrial

1

1

High-throughput

0.445

High

1052525

ATPB
ATP synthase subunit beta, mitochondrial

1

3

High-throughput

0.445

High

1306212

Q8IRD3
Glutathione peroxidase

1

2

High-throughput

0.445

High

1343097

Q8STA5
Histidine triad nucleotide binding protein 1, isoform A

1

2

High-throughput

0.445

High

1471189

Q9VD29
small monomeric GTPase

1

1

High-throughput

0.445

High

1472542

Q9VEB1
Malate dehydrogenase, mitochondrial

1

3

High-throughput

0.445

High

1477431

Q9VIE8
Aconitate hydratase, mitochondrial

1

3

High-throughput

0.445

High

1480394

Q9VL68
Enoyl-CoA delta isomerase 1, mitochondrial

1

1

High-throughput

0.445

High

1480925

SYAC
Alanine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.445

High

1483841

Q9VQ61
Aspartate aminotransferase

1

1

High-throughput

0.445

High

1486493

Q9VU35
10 kDa heat shock protein, mitochondrial

1

2

High-throughput

0.445

High

1487372

Q9VVL7
Dihydrolipoyl dehydrogenase

1

1

High-throughput

0.445

High

1489210

Q9W022
GEO01508p1

1

4

High-throughput

0.445

High

1489936

CISY
Probable citrate synthase, mitochondrial

1

4

High-throughput

0.445

High

1489938

Q9W457
Serine hydroxymethyltransferase

1

1

High-throughput

0.445

High

197908

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.426

High

305761

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.426

High

633024

GLNA1
Glutamine synthetase 1, mitochondrial

1

0

High-throughput

0.426

High

712457

CALR
Calreticulin

1

0

High-throughput

0.426

High

875512

KARG
Arginine kinase 1

1

0

High-throughput

0.426

High

1026687

SODM
Superoxide dismutase [Mn], mitochondrial

1

0

High-throughput

0.426

High

1070852

Q0KHZ6
Electron transfer flavoprotein subunit beta

1

0

High-throughput

0.426

High

1263112

Q7JXC4
CG6459 protein

1

0

High-throughput

0.426

High

1374757

ACPM
Acyl carrier protein, mitochondrial

1

0

High-throughput

0.426

High

1467699

Q9VAC1
GM14349p

1

0

High-throughput

0.426

High

1474338

Q9VG31
Malic enzyme

1

0

High-throughput

0.426

High

1474452

Q9VG69
LP03547p

1

0

High-throughput

0.426

High

1479340

Q9VKB0
threonine--tRNA ligase

1

0

High-throughput

0.426

High

1480459

Q9VL70
HL08109p

1

0

High-throughput

0.426

High

1485647

Q9VSI6
Isocitrate dehydrogenase [NADP]

1

0

High-throughput

0.426

High

1486800

GARS
Glycine--tRNA ligase

1

0

High-throughput

0.426

High

1489940

NSUN2
tRNA

1

0

High-throughput

0.426

High

2248

A0A0B4K7J4
Glial cell line-derived neurotrophic family receptor-like, isoform E

1

1

High-throughput

0.417

High

1070961

Q0KI87
Nuak family kinase, isoform A

1

2

High-throughput

0.417

High

1489740

Q9W283
Arc, isoform A

1

2

High-throughput

0.417

High

54124

A1Z892
1-Cys peroxiredoxin

1

2

High-throughput

0.407

High

57688

A1ZB71
Glutathione S transferase E6

1

1

High-throughput

0.407

High

234656

VINC
Vinculin

1

1

High-throughput

0.407

High

356482

O97102
Small ubiquitin-related modifier

1

1

High-throughput

0.407

High

426868

HP1
Heterochromatin protein 1

1

1

High-throughput

0.407

High

556819

PSA1
Proteasome subunit alpha type-1

1

1

High-throughput

0.407

High

578190

ENO
Enolase

1

3

High-throughput

0.407

High

611566

PSA4
Proteasome subunit alpha type-4

1

1

High-throughput

0.407

High

648990

ANXB9
Annexin B9

1

1

High-throughput

0.407

High

649160

ANX10
Annexin B10

1

1

High-throughput

0.407

High

652817

PSA71
Proteasome subunit alpha type-7-1

1

1

High-throughput

0.407

High

726534

VATB
V-type proton ATPase subunit B

1

3

High-throughput

0.407

High

821952

PSA2
Proteasome subunit alpha type-2

1

1

High-throughput

0.407

High

856188

MOEH
Moesin/ezrin/radixin homolog 1

1

1

High-throughput

0.407

High

871734

FKB12
Peptidyl-prolyl cis-trans isomerase Fkbp12

1

3

High-throughput

0.407

High

874744

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

1

High-throughput

0.407

High

929100

DOD
Putative peptidyl-prolyl cis-trans isomerase dodo

1

2

High-throughput

0.407

High

929620

PDI
Protein disulfide-isomerase

1

2

High-throughput

0.407

High

1031313

PGK
Phosphoglycerate kinase

1

1

High-throughput

0.407

High

1061484

GRAP
Growth factor receptor-bound protein 2

1

2

High-throughput

0.407

High

1176394

VATA2
V-type proton ATPase catalytic subunit A isoform 2

1

4

High-throughput

0.407

High

1176654

NLP
Nucleoplasmin-like protein

1

1

High-throughput

0.407

High

1191746

Q3YMU0
Protein disulfide-isomerase

1

1

High-throughput

0.407

High

1262213

Q7JVH6
LD24696p

1

5

High-throughput

0.407

High

1262908

Q7JX87
1-Cys peroxiredoxin

1

2

High-throughput

0.407

High

1264183

Q7K0E6
Aspartate--tRNA ligase, cytoplasmic

1

1

High-throughput

0.407

High

1268014

TERA
Transitional endoplasmic reticulum ATPase TER94

1

2

High-throughput

0.407

High

1268136

Q7KN85
ATP-citrate synthase

1

1

High-throughput

0.407

High

1322020

Q8MYY7
RE44624p

1

1

High-throughput

0.407

High

1345340

Q8T0L3
E1 ubiquitin-activating enzyme

1

1

High-throughput

0.407

High

1378873

Q960D4
SD06560p

1

2

High-throughput

0.407

High

1440645

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

1

High-throughput

0.407

High

1464393

Q9V3V2
peptidylprolyl isomerase

1

3

High-throughput

0.407

High

1465099

THIO2
Thioredoxin-2

1

3

High-throughput

0.407

High

1465317

PDIA6
Protein disulfide-isomerase A6 homolog

1

1

High-throughput

0.407

High

1466123

PSA3
Proteasome subunit alpha type-3

1

2

High-throughput

0.407

High

1467788

Q9VAC4
GEO09167p1

1

1

High-throughput

0.407

High

1468243

Q9VAN7
Phosphoglycerate mutase

1

1

High-throughput

0.407

High

1468707

Q9VAY2
Heat shock protein 83

1

5

High-throughput

0.407

High

1469045

Q9VB96
Uncharacterized protein, isoform A

1

2

High-throughput

0.407

High

1474809

Q9VGK3
peptidylprolyl isomerase

1

3

High-throughput

0.407

High

1475859

Q9VH81
protein-serine/threonine phosphatase

1

1

High-throughput

0.407

High

1476910

Q9VHX4
LD24679p

1

5

High-throughput

0.407

High

1478397

Q9VJD4
LD24721p

1

3

High-throughput

0.407

High

1480213

EF1D
Probable elongation factor 1-delta

1

1

High-throughput

0.407

High

1480534

FKB59
FK506-binding protein 59

1

2

High-throughput

0.407

High

1480557

Q9VL89
Methionine aminopeptidase 2

1

1

High-throughput

0.407

High

1480872

AK200
A-kinase anchor protein 200

1

2

High-throughput

0.407

High

1482484

PSB4
Proteasome subunit beta type-4

1

3

High-throughput

0.407

High

1483424

Q9VPN5
Stress-induced-phosphoprotein 1

1

4

High-throughput

0.407

High

1484337

Q9VQL1
serine--tRNA ligase

1

1

High-throughput

0.407

High

1485059

Q9VRP2
Uncharacterized protein, isoform A

1

1

High-throughput

0.407

High

1485698

Q9VSL2
Glutathione S transferase O3

1

1

High-throughput

0.407

High

1486356

Q9VTY2
Uncharacterized protein, isoform A

1

5

High-throughput

0.407

High

1486555

WDR1
Actin-interacting protein 1

1

2

High-throughput

0.407

High

1486639

Q9VUC1
Hsc70Cb, isoform A

1

3

High-throughput

0.407

High

1488594

CLIC
Chloride intracellular channel Clic

1

1

High-throughput

0.407

High

1489692

Q9W227
Peptidyl-prolyl cis-trans isomerase

1

2

High-throughput

0.407

High

1489937

WUHO
tRNA

1

1

High-throughput

0.407

High

1489941

PSB3
Proteasome subunit beta type-3

1

1

High-throughput

0.407

High

1489942

Q9XYZ9
Glutathione S transferase E12, isoform A

1

1

High-throughput

0.407

High

1489944

PSA6
Proteasome subunit alpha type-6

1

2

High-throughput

0.407

High

1489945

PURA
Adenylosuccinate synthetase

1

1

High-throughput

0.407

High

1489946

Q9Y112
BcDNA.GH10614

1

5

High-throughput

0.407

High

52464

A1Z6X6
Lactoylglutathione lyase

1

0

High-throughput

0.232

Low

57907

A1ZB77
Uncharacterized protein, isoform J

1

0

High-throughput

0.232

Low

86618

B9EQV3
Endoplasmic reticulum transmembrane protein

1

0

High-throughput

0.232

Low

195176

O16043
Anon1A4

1

0

High-throughput

0.232

Low

304753

RS21
Small ribosomal subunit protein eS21

1

0

High-throughput

0.232

Low

305294

TRMB
tRNA

1

0

High-throughput

0.232

Low

357409

O97428
Ciboulot, isoform A

1

0

High-throughput

0.232

Low

357645

INO1
Inositol-3-phosphate synthase

1

0

High-throughput

0.232

Low

460221

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.232

Low

609514

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.232

Low

682860

PROF
Profilin

1

0

High-throughput

0.232

Low

762677

UCHL
Ubiquitin carboxyl-terminal hydrolase

1

0

High-throughput

0.232

Low

835242

6PGD
6-phosphogluconate dehydrogenase, decarboxylating

1

0

High-throughput

0.232

Low

930265

VATE
V-type proton ATPase subunit E

1

0

High-throughput

0.232

Low

1014765

CYC2
Cytochrome c-2

1

0

High-throughput

0.232

Low

1052315

HMGD
High mobility group protein D

1

0

High-throughput

0.232

Low

1171834

ATPB2
Sodium/potassium-transporting ATPase subunit beta-2

1

0

High-throughput

0.232

Low

1176774

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.232

Low

1260926

Q76NR6
Regucalcin

1

0

High-throughput

0.232

Low

1263190

SEELE
Protein seele

1

0

High-throughput

0.232

Low

1264766

Q7K148
Proteasome subunit beta

1

0

High-throughput

0.232

Low

1265348

Q7K2K2
FI04612p

1

0

High-throughput

0.232

Low

1268318

Q7KN99
Phosphopantothenoylcysteine synthetase, isoform A

1

0

High-throughput

0.232

Low

1269536

Q7KTW5
Inositol-1-monophosphatase

1

0

High-throughput

0.232

Low

1304011

Q8INK3
Fatty acid-binding protein, muscle

1

0

High-throughput

0.232

Low

1305815

Q8IQZ7
FI19014p1

1

0

High-throughput

0.232

Low

1321769

Q8MT58
Carnosine dipeptidase 2, isoform A

1

0

High-throughput

0.232

Low

1343383

OLA1
Obg-like ATPase 1

1

0

High-throughput

0.232

Low

1344494

Q8SYG3
E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.232

Low

1374643

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

High-throughput

0.232

Low

1377750

FAXC
Failed axon connections

1

0

High-throughput

0.232

Low

1427923

IF5A
Eukaryotic translation initiation factor 5A

1

0

High-throughput

0.232

Low

1440103

JUPIT
Microtubule-associated protein Jupiter

1

0

High-throughput

0.232

Low

1440231

NASP
Nuclear autoantigenic sperm protein homolog

1

0

High-throughput

0.232

Low

1445499

SH3BG
SH3 domain-binding glutamic acid-rich protein homolog

1

0

High-throughput

0.232

Low

1463735

Q9V3I1
Deoxyuridine 5'-triphosphate nucleotidohydrolase

1

0

High-throughput

0.232

Low

1464649

Q9V3V9
Endonuclease G inhibitor, isoform A

1

0

High-throughput

0.232

Low

1466295

TPP2
Tripeptidyl-peptidase 2

1

0

High-throughput

0.232

Low

1467034

Q9V9U3
LD45254p

1

0

High-throughput

0.232

Low

1469558

Q9VBR6
RE74917p

1

0

High-throughput

0.232

Low

1470563

Q9VCK6
LD34157p

1

0

High-throughput

0.232

Low

1471026

Q9VD02
GH14779p

1

0

High-throughput

0.232

Low

1472993

FLNA
Filamin-A

1

0

High-throughput

0.232

Low

1475166

TCTP
Translationally-controlled tumor protein homolog

1

0

High-throughput

0.232

Low

1475999

TEBPH
Cytosolic Prostaglandin E synthase

1

0

High-throughput

0.232

Low

1476518

Q9VHN7
transketolase

1

0

High-throughput

0.232

Low

1476651

DPP3
Dipeptidyl peptidase 3

1

0

High-throughput

0.232

Low

1479956

Q9VKW5
Prolyl endopeptidase

1

0

High-throughput

0.232

Low

1480667

Q9VLB7
Rab GDP dissociation inhibitor

1

0

High-throughput

0.232

Low

1482018

Q9VMU6
LD31822p

1

0

High-throughput

0.232

Low

1482525

Q9VNB2
RE42193p

1

0

High-throughput

0.232

Low

1483718

Q9VPX6
Adenylyl cyclase-associated protein

1

0

High-throughput

0.232

Low

1484162

BACC
Bacchus

1

0

High-throughput

0.232

Low

1484371

Q9VQL7
Fatty acid synthase

1

0

High-throughput

0.232

Low

1484856

Q9VRD6
NTF2-related export protein

1

0

High-throughput

0.232

Low

1484983

Q9VRL1
GEO06356p1

1

0

High-throughput

0.232

Low

1487202

Y9705
Cold shock domain-containing protein CG9705

1

0

High-throughput

0.232

Low

1487678

Q9VW59
Rho GDP-dissociation inhibitor 3

1

0

High-throughput

0.232

Low

1487852

RS10B
Small ribosomal subunit protein eS10B

1

0

High-throughput

0.232

Low

1488040

Q9VWV5
5' nucleotidase B, isoform G

1

0

High-throughput

0.232

Low

1488273

DHB4
Peroxisomal multifunctional enzyme type 2

1

0

High-throughput

0.232

Low

1489057

Q9VZI1
Transgelin

1

0

High-throughput

0.232

Low

1489348

Q9W0H8
Reticulocalbin-3

1

0

High-throughput

0.232

Low

1489461

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.232

Low

1489566

TALDO
Probable transaldolase

1

0

High-throughput

0.232

Low

1489782

Q9W2M4
Farnesoic acid O-methyl transferase domain-containing protein

1

0

High-throughput

0.232

Low

1489863

Q9W3F6
Bleomycin hydrolase

1

0

High-throughput

0.232

Low

1489935

Q9W3Y3
Calcyclin-binding protein

1

0

High-throughput

0.232

Low

1489939

Q9W478
RE43153p

1

0

High-throughput

0.232

Low

1489943

Q9XZ57
Eb1, isoform E

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025