HitPredict

Interactor 1: H2AZ (P0C0S5)
Histone H2A.Z (H2A/z)
Gene: H2AZ1

Interactor 2: H31 (P68431)
Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
Gene: H3C1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	1.00	0.928

Property	Details
Experiments	34349018, 23415232, 34079125, 33961781, 16622419, 24463511
Identification Methods	cross-linking study, affinity chromatography technology, proximity labelling technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~Histone, Histone~Histone_H2A_C
Common GO terms	GO:0000786 - nucleosome GO:0005634 - nucleus GO:0006325 - chromatin organization GO:0030527 - structural constituent of chromatin GO:0046982 - protein heterodimerization activity and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 128 Hs			1 136
+	Mm
		470229 H2AZ_MOUSE (1-128): 9.79e-62: 186: 100.00		H31_MOUSE (1-136): 2.8e-62: 188: 100.00
+	Hs
		470036 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		H31T_HUMAN (1-136): 1.27e-61: 187: 97.06
+	Mm
		470231 H2AZ_MOUSE (1-128): 9.79e-62: 186: 100.00		H33_MOUSE (1-136): 2.73e-61: 186: 96.32
+	Hs
		470061 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		H32_HUMAN (1-136): 6.5e-61: 185: 99.27
+	Mm
		470230 H2AZ_MOUSE (1-128): 9.79e-62: 186: 100.00		H32_MOUSE (1-136): 6.5e-61: 185: 99.27
+	Hs
		934914 H2AV_HUMAN (1-127): 2.06e-60: 183: 98.43		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		1086191 H2AV_HUMAN (1-127): 2.06e-60: 183: 98.43		H31T_HUMAN (1-136): 1.27e-61: 187: 97.06
+	Hs
		935141 H2A1A_HUMAN (5-125): 2.16e-56: 173: 61.48		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		1157204 H2AV_HUMAN (1-127): 2.06e-60: 183: 98.43		H3C_HUMAN (1-136): 5.49e-58: 177: 93.38
+	Hs
		934946 H2A2B_HUMAN (5-127): 9.2e-56: 171: 59.68		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		935170 H2A1J_HUMAN (5-125): 1.24e-55: 171: 61.48		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Mm
		935458 Q8CGP4_MOUSE (5-127): 1.37e-55: 171: 59.68		H31_MOUSE (1-136): 2.8e-62: 188: 100.00
+	Hs
		1086203 H2A2B_HUMAN (5-127): 9.2e-56: 171: 59.68		H31T_HUMAN (1-136): 1.27e-61: 187: 97.06
+	Hs
		1086293 H2A1J_HUMAN (5-125): 1.24e-55: 171: 61.48		H31T_HUMAN (1-136): 1.27e-61: 187: 97.06
+	Hs
		952450 H2A2B_HUMAN (5-127): 9.2e-56: 171: 59.68		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Mm
		952759 Q8CGP4_MOUSE (5-127): 1.37e-55: 171: 59.68		H33_MOUSE (1-136): 2.73e-61: 186: 96.32
+	Hs
		1174640 H2A1J_HUMAN (5-125): 1.24e-55: 171: 61.48		H32_HUMAN (1-136): 6.5e-61: 185: 99.27
+	Mm
		952264 Q8CGP4_MOUSE (5-127): 1.37e-55: 171: 59.68		H32_MOUSE (1-136): 6.5e-61: 185: 99.27
+	Hs
		1157222 H2A1J_HUMAN (5-125): 1.24e-55: 171: 61.48		H3C_HUMAN (1-136): 5.49e-58: 177: 93.38
+	Hs
		469965 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		CENPA_HUMAN (9-133): 5.62e-45: 145: 50.00