Protein: PUR8
Adenylosuccinate lyase (ADSL) (ASL) (EC 4.3.2.2) (Adenylosuccinase) (ASase)

Gene: PUR8, ADSL
Organism: Homo sapiens
Interactions: 132
UniProt ID: P30566

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0004018 - N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity
GO:0005829 - cytosol
GO:0006164 - purine nucleotide biosynthetic process
GO:0006167 - AMP biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

720781

SERB1
SERPINE1 mRNA-binding protein 1

2

1

High-throughput

0.611

High

720819

KLH20
Kelch-like protein 20

2

1

High-throughput

0.611

High

720820

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

2

3

High-throughput

0.611

High

240854

PRKN
E3 ubiquitin-protein ligase parkin

2

3

High-throughput

0.584

High

720786

TEKT4
Tektin-4

2

1

High-throughput

0.558

High

720812

TEKT2
Tektin-2

2

1

High-throughput

0.558

High

720791

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

274478

DNJB6
DnaJ homolog subfamily B member 6

1

1

High-throughput

0.536

High

720748

MTPN
Myotrophin

1

1

High-throughput

0.536

High

720755

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

2

High-throughput

0.536

High

720792

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

1

High-throughput

0.536

High

720805

E41L5
Band 4.1-like protein 5

1

1

High-throughput

0.536

High

720822

SAR1B
Small COPII coat GTPase SAR1B

1

1

High-throughput

0.536

High

720739

CCN3
CCN family member 3

1

0

High-throughput

0.518

High

720756

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.518

High

488204

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

1

0

High-throughput

0.513

High

708927

T2EB
Transcription initiation factor IIE subunit beta

1

0

High-throughput

0.513

High

720742

ST1A2
Sulfotransferase 1A2

1

0

High-throughput

0.513

High

185455

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

3

High-throughput

0.501

High

720753

REL
Proto-oncogene c-Rel

1

3

High-throughput

0.481

High

451602

GPX1
Glutathione peroxidase 1

1

2

High-throughput

0.479

High

507575

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.479

High

534691

BIP
Endoplasmic reticulum chaperone BiP

1

3

High-throughput

0.479

High

536584

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

720083

PURA2
Adenylosuccinate synthetase isozyme 2

1

1

High-throughput

0.479

High

720738

YAP1
Transcriptional coactivator YAP1

1

1

High-throughput

0.479

High

720743

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

2

High-throughput

0.479

High

720745

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

1

High-throughput

0.479

High

720746

TERA
Transitional endoplasmic reticulum ATPase

1

2

Small-scale

0.479

High

720751

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

3

High-throughput

0.479

High

720752

1433Z
14-3-3 protein zeta/delta

1

2

High-throughput

0.479

High

720754

TP4A2
Protein tyrosine phosphatase type IVA 2

1

2

High-throughput

0.479

High

720757

SBP1
Methanethiol oxidase

1

1

High-throughput

0.479

High

720759

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

720763

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

720779

CNTRB
Centrobin

1

1

High-throughput

0.479

High

720782

COP1
E3 ubiquitin-protein ligase COP1

1

3

High-throughput

0.479

High

720784

FBF1
Fas-binding factor 1

1

1

High-throughput

0.479

High

720790

ARMC5
Armadillo repeat-containing protein 5

1

1

High-throughput

0.479

High

720793

RPGR1
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1

1

2

High-throughput

0.479

High

720795

CEP89
Centrosomal protein of 89 kDa

1

1

High-throughput

0.479

High

720796

ACON
Aconitate hydratase, mitochondrial

1

3

High-throughput

0.479

High

720808

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

1

2

High-throughput

0.479

High

720810

SYLC
Leucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

720811

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

720815

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

2

High-throughput

0.479

High

720816

MTMR7
Phosphatidylinositol-3-phosphate phosphatase MTMR7

1

1

High-throughput

0.479

High

158125

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.458

High

289933

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

324093

CE152
Centrosomal protein of 152 kDa

1

0

High-throughput

0.458

High

326523

MFN2
Mitofusin-2

1

0

High-throughput

0.458

High

341903

CEP43
Centrosomal protein 43

1

0

High-throughput

0.458

High

343560

OXSR1
Serine/threonine-protein kinase OSR1

1

0

High-throughput

0.458

High

345420

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

371268

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

411433

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

475901

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

0

High-throughput

0.458

High

666073

PPAC
Low molecular weight phosphotyrosine protein phosphatase

1

0

High-throughput

0.458

High

693245

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

0

High-throughput

0.458

High

720733

CTNB1
Catenin beta-1

1

0

High-throughput

0.458

High

720740

PAXI
Paxillin

1

0

High-throughput

0.458

High

720741

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

720747

HDAC4
Histone deacetylase 4

1

0

High-throughput

0.458

High

720750

RS15A
Small ribosomal subunit protein uS8

1

0

High-throughput

0.458

High

720764

PCBP1
Poly(rC)-binding protein 1

1

0

High-throughput

0.458

High

720767

TENS2
Tensin-2

1

0

High-throughput

0.458

High

720768

CP135
Centrosomal protein of 135 kDa

1

0

High-throughput

0.458

High

720775

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

720778

YAF2
YY1-associated factor 2

1

0

High-throughput

0.458

High

720794

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

720799

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

720804

CPAP
Centrosomal P4.1-associated protein

1

0

High-throughput

0.458

High

720817

ADIP
Afadin- and alpha-actinin-binding protein

1

0

High-throughput

0.458

High

563273

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

626088

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

3

High-throughput

0.445

High

720736

GPX4
Phospholipid hydroperoxide glutathione peroxidase GPX4

1

2

High-throughput

0.445

High

720769

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.445

High

720777

CARM1
Histone-arginine methyltransferase CARM1

1

1

High-throughput

0.445

High

105421

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

217879

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

302147

NEBL
Nebulette

1

1

High-throughput

0.437

High

587999

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

715314

ODPAT
Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial

1

1

High-throughput

0.437

High

720744

TXTP
Tricarboxylate transport protein, mitochondrial

1

1

High-throughput

0.437

High

720762

HAPR1
HUWE1-associated protein modifying stress responses 1

1

1

High-throughput

0.437

High

720771

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

720772

CE128
Centrosomal protein of 128 kDa

1

1

High-throughput

0.437

High

720774

MAVS
Mitochondrial antiviral-signaling protein

1

1

High-throughput

0.437

High

720783

DCA11
DDB1- and CUL4-associated factor 11

1

1

High-throughput

0.437

High

720788

TP4A1
Protein tyrosine phosphatase type IVA 1

1

2

High-throughput

0.437

High

720800

GCP60
Golgi resident protein GCP60

1

1

High-throughput

0.437

High

720801

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

720823

MTCH2
Mitochondrial carrier homolog 2

1

2

High-throughput

0.437

High

429371

JUN
Transcription factor Jun

1

2

High-throughput

0.407

High

628605

CAP7
Azurocidin

1

1

High-throughput

0.407

High

720813

CBLC
E3 ubiquitin-protein ligase CBL-C

1

1

High-throughput

0.407

High

720776

CMTD1
Catechol O-methyltransferase domain-containing protein 1

2

0

High-throughput

0.318

High

215980

FIBP
Acidic fibroblast growth factor intracellular-binding protein

1

0

High-throughput

0.279

Low

387796

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

0

High-throughput

0.279

Low

720737

MAGA9
Melanoma-associated antigen 9

1

0

High-throughput

0.279

Low

720760

KRR1
KRR1 small subunit processome component homolog

1

0

High-throughput

0.279

Low

720780

F133A
Protein FAM133A

1

0

High-throughput

0.279

Low

720785

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.279

Low

720797

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.279

Low

720798

DERL2
Derlin-2

1

0

High-throughput

0.279

Low

720802

PAAT
ATPase PAAT

1

0

High-throughput

0.279

Low

720807

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

1

0

High-throughput

0.279

Low

720818

NTNG1
Netrin-G1

1

0

High-throughput

0.279

Low

720821

WIF1
Wnt inhibitory factor 1

1

0

High-throughput

0.279

Low

720814

EPDR1
Mammalian ependymin-related protein 1

1

0

High-throughput

0.269

Low

228448

LANC1
Glutathione S-transferase LANCL1

1

0

Small-scale

0.249

Low

245312

CE104
Centrosomal protein of 104 kDa

1

0

High-throughput

0.249

Low

279288

TULP3
Tubby-related protein 3

1

0

High-throughput

0.249

Low

341527

EYA4
Protein phosphatase EYA4

1

0

High-throughput

0.249

Low

376731

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

High-throughput

0.249

Low

694710

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

720734

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

720735

BMR1A
Bone morphogenetic protein receptor type-1A

1

0

High-throughput

0.249

Low

720749

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

720761

CUL4A
Cullin-4A

1

0

High-throughput

0.249

Low

720765

ANR55
Ankyrin repeat domain-containing protein 55

1

0

High-throughput

0.249

Low

720766

BSPRY
B box and SPRY domain-containing protein

1

0

High-throughput

0.249

Low

720773

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

720787

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.249

Low

720789

VP33A
Vacuolar protein sorting-associated protein 33A

1

0

High-throughput

0.249

Low

720803

SFXN1
Sideroflexin-1

1

0

High-throughput

0.249

Low

720806

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.249

Low

720809

SEP10
Septin-10

1

0

High-throughput

0.249

Low

330055

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low

653150

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

720758

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

720770

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025