HitPredict

Interactor 1: H2AZ (P0C0S5)
Histone H2A.Z (H2A/z)
Gene: H2AZ1

Interactor 2: PRKDC (P78527)
DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (p460)
Gene: PRKDC

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	35271311, 24463511
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 128 Hs			1 4128
+	Hs
		391652 H2A1B_HUMAN (5-125): 9.18e-55: 169: 61.48		PRKDC_HUMAN (1-4128): 0: 6819: 100.00
+	Hs
		470338 H2A1_HUMAN (5-125): 8.23e-55: 169: 61.48		PRKDC_HUMAN (1-4128): 0: 6819: 100.00
+	Hs
		555412 H2AX_HUMAN (5-124): 1.08e-54: 169: 61.98		PRKDC_HUMAN (1-4128): 0: 6819: 100.00
+	Hs
		470215 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		TRRAP_HUMAN (2754-4128): 0: 828: 15.88
+	Hs
		1300657 H2A1A_HUMAN (5-125): 2.16e-56: 173: 61.48		TRRAP_HUMAN (2754-4128): 0: 828: 15.88
+	Hs
		1296219 H2A1H_HUMAN (5-125): 2.98e-55: 170: 61.48		TRRAP_HUMAN (2754-4128): 0: 828: 15.88
+	Hs
		594872 H2A1D_HUMAN (5-125): 7.06e-55: 169: 62.30		TRRAP_HUMAN (2754-4128): 0: 828: 15.88
+	Mm
		650187 H2AX_MOUSE (5-124): 1.8e-54: 169: 61.98		ATM_MOUSE (3216-4128): 1.17e-165: 580: 18.84
+	Hs
		555448 H2AX_HUMAN (5-124): 1.08e-54: 169: 61.98		ATM_HUMAN (3218-4128): 1.84e-158: 557: 19.42
+	Hs
		555452 H2AX_HUMAN (5-124): 1.08e-54: 169: 61.98		ATR_HUMAN (3377-4128): 2.05e-122: 438: 19.28
+	Dm
		446316 H2AV_DROME (1-125): 2.57e-60: 183: 96.00		ATM_DROME (3050-4128): 8.44e-108: 391: 16.42
+	Sc
		755479 H2AZ_YEAST (4-126): 3.32e-39: 129: 65.91		TRA1_YEAST (2924-4127): 1.79e-115: 416: 14.57