HitPredict

Interactor 1: H2AZ (P0C0S5)
Histone H2A.Z (H2A/z)
Gene: H2AZ1

Interactor 2: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.855

Property	Details
Experiments	35271311, 30021884, 37071682
Identification Methods	affinity chromatography technology, proximity labelling technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~Histone, Histone~Histone_H2A_C
Common GO terms	GO:0000786 - nucleosome GO:0005634 - nucleus GO:0030527 - structural constituent of chromatin GO:0046982 - protein heterodimerization activity GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 128 Hs			1 126
+	Hs
		470046 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		H2B2F_HUMAN (1-126): 2.34e-54: 168: 97.62
+	Hs
		469948 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		H2B1O_HUMAN (1-126): 3.25e-54: 167: 99.21
+	Hs
		420793 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		H2B1J_HUMAN (1-126): 7.8e-54: 166: 99.21
+	Hs
		469983 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		H2BFS_HUMAN (1-126): 1.26e-53: 166: 96.83
+	Hs
		469988 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		470118 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41
+	Hs
		1129818 H2AV_HUMAN (1-127): 2.06e-60: 183: 98.43		H2B2F_HUMAN (1-126): 2.34e-54: 168: 97.62
+	Hs
		241424 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Hs
		469955 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		469984 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		H2B1D_HUMAN (1-126): 3.5e-53: 164: 98.41
+	Hs
		1175296 H2AV_HUMAN (1-127): 2.06e-60: 183: 98.43		H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41
+	Hs
		420848 H2AV_HUMAN (1-127): 2.06e-60: 183: 98.43		H2B1J_HUMAN (1-126): 7.8e-54: 166: 99.21
+	Hs
		883032 H2AV_HUMAN (1-127): 2.06e-60: 183: 98.43		H2BFS_HUMAN (1-126): 1.26e-53: 166: 96.83
+	Hs
		918464 H2AV_HUMAN (1-127): 2.06e-60: 183: 98.43		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		241566 H2AV_HUMAN (1-127): 2.06e-60: 183: 98.43		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Hs
		470139 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		H2B1L_HUMAN (1-126): 2.49e-52: 162: 97.62
+	Hs
		470086 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03
+	Hs
		886139 H2AV_HUMAN (1-127): 2.06e-60: 183: 98.43		H2B1D_HUMAN (1-126): 3.5e-53: 164: 98.41
+	Hs
		470121 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		H2B1A_HUMAN (1-126): 3.43e-46: 147: 85.04
+	Hs
		1175297 H2AV_HUMAN (1-127): 2.06e-60: 183: 98.43		H2B1A_HUMAN (1-126): 3.43e-46: 147: 85.04