HitPredict

Interactor 1: H2AZ (P0C0S5)
Histone H2A.Z (H2A/z)
Gene: H2AZ1

Interactor 2: RUVB1 (Q9Y265)
RuvB-like 1 (EC 3.6.4.12) (49 kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (54 kDa erythrocyte cytosolic protein) (ECP-54) (INO80 complex subunit H) (Nuclear matrix protein 238) (NMP 238) (Pontin 52) (TIP49a) (TIP60-associated protein 54-alpha) (TAP54-alpha)
Gene: RUVBL1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.729

Property	Details
Experiments	33961781, 28242625, 35271311, 17721549, 22467210, 24463511
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000786 - nucleosome GO:0005634 - nucleus GO:0070062 - extracellular exosome
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 128 Hs			1 456
+	Hs
		470615 H2A1_HUMAN (5-125): 8.23e-55: 169: 61.48		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Hs
		555699 H2AX_HUMAN (5-124): 1.08e-54: 169: 61.98		RUVB1_HUMAN (1-456): 0: 704: 100.00
+	Dm
		446324 H2AV_DROME (1-125): 2.57e-60: 183: 96.00		RUVB1_DROME (1-455): 0: 660: 79.56
+	Hs
		470207 H2AZ_HUMAN (1-128): 9.79e-62: 186: 100.00		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Hs
		1175321 H2AV_HUMAN (1-127): 2.06e-60: 183: 98.43		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Hs
		1216283 H2A2B_HUMAN (5-127): 9.2e-56: 171: 59.68		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Hs
		1151396 H2A2A_HUMAN (5-125): 4.61e-55: 169: 62.30		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Hs
		470613 H2A1_HUMAN (5-125): 8.23e-55: 169: 61.48		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Hs
		555695 H2AX_HUMAN (5-124): 1.08e-54: 169: 61.98		RUVB2_HUMAN (2-455): 0: 651: 42.76
+	Sp
		815623 H2AZ_SCHPO (18-119): 1.91e-46: 148: 78.43		RUVB1_SCHPO (1-456): 0: 671: 69.96
+	Sp
		294002 H2AZ_SCHPO (18-119): 1.91e-46: 148: 78.43		RUVB2_SCHPO (1-455): 0: 639: 42.45
+	Sc
		978066 H2AZ_YEAST (4-126): 3.32e-39: 129: 65.91		RUVB1_YEAST (1-455): 0: 652: 67.39
+	Sc
		1015643 H2AZ_YEAST (4-126): 3.32e-39: 129: 65.91		RUVB2_YEAST (5-455): 0: 627: 41.72