Protein: NUCG
Endonuclease G, mitochondrial (Endo G) (EC 3.1.30.-)

Gene: NUCG, ENDOG
Organism: Homo sapiens
Interactions: 59
UniProt ID: Q14249

Gene Ontology (top 5):
GO:0000014 - single-stranded DNA endodeoxyribonuclease activity
GO:0000287 - magnesium ion binding
GO:0001701 - in utero embryonic development
GO:0003676 - nucleic acid binding
GO:0004520 - DNA endonuclease activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

727801

DNJA1
DnaJ homolog subfamily A member 1

5

3

High-throughput

0.720

High

537149

HSP7C
Heat shock cognate 71 kDa protein

3

1

High-throughput

0.662

High

930886

HSP72
Heat shock-related 70 kDa protein 2

3

1

High-throughput

0.650

High

348502

AIFM1
Apoptosis-inducing factor 1, mitochondrial

3

3

Small-scale

0.640

High

482898

TPM1
Tropomyosin alpha-1 chain

3

0

High-throughput

0.638

High

650549

KAPCG
cAMP-dependent protein kinase catalytic subunit gamma

2

1

High-throughput

0.628

High

761677

HSP74
Heat shock 70 kDa protein 4

2

1

Small-scale

0.611

High

1116200

PTC1
Protein patched homolog 1

2

2

High-throughput

0.611

High

1124779

ITLN1
Intelectin-1

3

1

High-throughput

0.609

High

1124780

ITLN2
Intelectin-2

3

1

High-throughput

0.604

High

336666

BAG4
BAG family molecular chaperone regulator 4

2

0

High-throughput

0.602

High

766089

PCGF2
Polycomb group RING finger protein 2

2

0

High-throughput

0.602

High

1119546

NFYC
Nuclear transcription factor Y subunit gamma

2

0

High-throughput

0.602

High

258878

DNJA2
DnaJ homolog subfamily A member 2

3

3

High-throughput

0.599

High

1124795

SFXN1
Sideroflexin-1

2

1

High-throughput

0.584

High

710707

EPHA8
Ephrin type-A receptor 8

2

2

High-throughput

0.574

High

846744

GRK6
G protein-coupled receptor kinase 6

2

2

High-throughput

0.574

High

1124778

DNJA4
DnaJ homolog subfamily A member 4

2

3

High-throughput

0.573

High

920696

NUBP1
Cytosolic Fe-S cluster assembly factor NUBP1

1

1

High-throughput

0.536

High

231307

EFNA2
Ephrin-A2

1

0

High-throughput

0.513

High

296703

TUSC2
Tumor suppressor candidate 2

1

0

High-throughput

0.513

High

1124791

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.513

High

1124775

EPHA7
Ephrin type-A receptor 7

1

2

High-throughput

0.489

High

332403

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

1

0

High-throughput

0.480

High

507964

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

292126

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

3

High-throughput

0.479

High

487307

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

814525

FEN1
Flap endonuclease 1

1

1

Small-scale

0.479

High

1107398

BIRC2
Baculoviral IAP repeat-containing protein 2

1

2

Small-scale

0.479

High

1124785

AURKB
Aurora kinase B

1

3

High-throughput

0.479

High

1124787

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.479

High

1124792

MIC26
MICOS complex subunit MIC26

1

1

High-throughput

0.479

High

1124793

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

4

High-throughput

0.479

High

1124794

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

1

High-throughput

0.479

High

216692

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.458

High

296240

SCO1
Protein SCO1 homolog, mitochondrial

1

0

High-throughput

0.458

High

559953

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.458

High

1013387

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

1124781

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.458

High

1124784

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.458

High

1124786

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

1124788

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

0

High-throughput

0.458

High

1124790

PHB2
Prohibitin-2

1

0

High-throughput

0.458

High

1124796

PLRKT
Plasminogen receptor

1

0

High-throughput

0.458

High

1124797

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

1124801

CHIP
E3 ubiquitin-protein ligase CHIP

1

0

Small-scale

0.458

High

1124776

SCMC2
Mitochondrial adenyl nucleotide antiporter SLC25A25

1

3

High-throughput

0.445

High

1124782

Q96BE0
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.437

High

1124789

DNJC7
DnaJ homolog subfamily C member 7

1

1

High-throughput

0.437

High

1124798

DNJB4
DnaJ homolog subfamily B member 4

1

3

High-throughput

0.407

High

239062

ZNRD2
Protein ZNRD2

2

0

High-throughput

0.328

High

1124799

EVL
Ena/VASP-like protein

2

0

High-throughput

0.328

High

347017

BAG2
BAG family molecular chaperone regulator 2

2

0

High-throughput

0.313

High

1124800

CBPA4
Carboxypeptidase A4

2

0

High-throughput

0.313

High

190360

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.279

Low

702396

CYTD
Cystatin-D

1

0

High-throughput

0.279

Low

1054583

PSME1
Proteasome activator complex subunit 1

1

0

High-throughput

0.279

Low

1124783

KCD12
BTB/POZ domain-containing protein KCTD12

1

0

High-throughput

0.279

Low

1124777

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025