HitPredict

Interactor 1: H2A1 (P0C0S8)
Histone H2A type 1 (H2A.1) (Histone H2A/ptl)
Gene: H2AC11

Interactor 2: H33 (P84243)
Histone H3.3
Gene: H3-3A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	33961781, 34349018
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~Histone, Histone~Histone_H2A_C
Common GO terms	GO:0000786 - nucleosome GO:0005634 - nucleus GO:0030527 - structural constituent of chromatin GO:0031492 - nucleosomal DNA binding GO:0046982 - protein heterodimerization activity and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 130 Hs			1 136
+	Hs
		470336 H2A1_HUMAN (1-130): 8.4e-68: 202: 100.00		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		934877 H2A2A_HUMAN (1-130): 6.74e-68: 202: 98.46		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		391649 H2A1B_HUMAN (1-130): 1.13e-67: 201: 98.46		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		935170 H2A1J_HUMAN (1-128): 2.78e-67: 201: 99.22		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		1086182 H2A2A_HUMAN (1-130): 6.74e-68: 202: 98.46		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		1086192 H2A3_HUMAN (1-130): 9.27e-68: 202: 97.69		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		391655 H2A1B_HUMAN (1-130): 1.13e-67: 201: 98.46		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		470399 H2A1_HUMAN (1-130): 8.4e-68: 202: 100.00		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		1086293 H2A1J_HUMAN (1-128): 2.78e-67: 201: 99.22		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		1151344 H2A2A_HUMAN (1-130): 6.74e-68: 202: 98.46		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Hs
		1174619 H2A1C_HUMAN (1-130): 8.04e-68: 202: 98.46		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Hs
		391723 H2A1B_HUMAN (1-130): 1.13e-67: 201: 98.46		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		470427 H2A1_HUMAN (1-130): 8.4e-68: 202: 100.00		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Hs
		1174640 H2A1J_HUMAN (1-128): 2.78e-67: 201: 99.22		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Hs
		391757 H2A1B_HUMAN (1-130): 1.13e-67: 201: 98.46		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Hs
		470413 H2A1_HUMAN (1-130): 8.4e-68: 202: 100.00		H37_HUMAN (1-136): 4.54e-57: 175: 94.12
+	Hs
		391740 H2A1B_HUMAN (1-130): 1.13e-67: 201: 98.46		H37_HUMAN (1-136): 4.54e-57: 175: 94.12
+	Hs
		1157222 H2A1J_HUMAN (1-128): 2.78e-67: 201: 99.22		H3C_HUMAN (1-136): 1.99e-56: 173: 95.59
+	Hs
		594830 H2A1D_HUMAN (1-130): 9.47e-68: 202: 99.23		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76
+	Hs
		391597 H2A1B_HUMAN (1-130): 1.13e-67: 201: 98.46		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76