Protein: ECEL1
Endothelin-converting enzyme-like 1 (EC 3.4.24.-) (Xce protein)

Gene: ECEL1
Organism: Homo sapiens
Interactions: 134
UniProt ID: O95672

Gene Ontology (top 5):
GO:0003016 - respiratory system process
GO:0004222 - metalloendopeptidase activity
GO:0005886 - plasma membrane
GO:0007218 - neuropeptide signaling pathway
GO:0008237 - metallopeptidase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

341292

ECE1
Endothelin-converting enzyme 1

1

1

High-throughput

0.691

High

341281

HLAE
HLA class I histocompatibility antigen, alpha chain E

3

4

High-throughput

0.667

High

341286

CD1B
T-cell surface glycoprotein CD1b

3

9

High-throughput

0.667

High

341375

CLC2D
C-type lectin domain family 2 member D

2

4

High-throughput

0.628

High

341331

ABD12
Lysophosphatidylserine lipase ABHD12

2

0

High-throughput

0.576

High

341301

SG2A2
Mammaglobin-A

2

1

High-throughput

0.574

High

170598

CLGN
Calmegin

2

4

High-throughput

0.549

High

341285

CALX
Calnexin

2

4

High-throughput

0.549

High

341300

DNJC3
DnaJ homolog subfamily C member 3

2

6

High-throughput

0.549

High

341372

DNJB9
DnaJ homolog subfamily B member 9

2

4

High-throughput

0.549

High

341380

DJC16
DnaJ homolog subfamily C member 16

2

5

High-throughput

0.549

High

132545

UPK1A
Uroplakin-1a

1

9

High-throughput

0.536

High

160958

ADA10
Disintegrin and metalloproteinase domain-containing protein 10

1

3

High-throughput

0.536

High

175288

PLXB2
Plexin-B2

1

2

High-throughput

0.536

High

287505

LRP6
Low-density lipoprotein receptor-related protein 6

1

1

High-throughput

0.536

High

341268

LDLR
Low-density lipoprotein receptor

1

1

High-throughput

0.536

High

341269

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

7

High-throughput

0.536

High

341270

DQA1
HLA class II histocompatibility antigen, DQ alpha 1 chain

1

8

High-throughput

0.536

High

341272

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

1

9

High-throughput

0.536

High

341274

CD1A
T-cell surface glycoprotein CD1a

1

8

High-throughput

0.536

High

341275

INSR
Insulin receptor

1

1

High-throughput

0.536

High

341276

ITAV
Integrin alpha-V

1

1

High-throughput

0.536

High

341277

PROS
Vitamin K-dependent protein S

1

1

High-throughput

0.536

High

341279

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.536

High

341283

ITB4
Integrin beta-4

1

1

High-throughput

0.536

High

341284

ITB5
Integrin beta-5

1

3

High-throughput

0.536

High

341287

HLAF
HLA class I histocompatibility antigen, alpha chain F

1

4

High-throughput

0.536

High

341288

CEAM8
Cell adhesion molecule CEACAM8

1

1

High-throughput

0.536

High

341290

TGFR1
TGF-beta receptor type-1

1

1

High-throughput

0.536

High

341293

CD151
CD151 antigen

1

8

High-throughput

0.536

High

341294

MA2A2
Alpha-mannosidase 2x

1

1

High-throughput

0.536

High

341296

ADA17
Disintegrin and metalloproteinase domain-containing protein 17

1

3

High-throughput

0.536

High

341298

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

2

High-throughput

0.536

High

341304

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

3

High-throughput

0.536

High

341305

STIM1
Stromal interaction molecule 1

1

1

High-throughput

0.536

High

341306

ITA7
Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]

1

1

High-throughput

0.536

High

341312

MA2A1
Alpha-mannosidase 2

1

1

High-throughput

0.536

High

341315

HFE
Hereditary hemochromatosis protein

1

5

High-throughput

0.536

High

341326

GALT7
N-acetylgalactosaminyltransferase 7

1

2

High-throughput

0.536

High

341330

GLT12
Polypeptide N-acetylgalactosaminyltransferase 12

1

2

High-throughput

0.536

High

341344

HMR1
Major histocompatibility complex class I-related protein 1

1

5

High-throughput

0.536

High

341349

TMX3
Protein disulfide-isomerase TMX3

1

4

High-throughput

0.536

High

341355

LRFN3
Leucine-rich repeat and fibronectin type-III domain-containing protein 3

1

1

High-throughput

0.536

High

341356

TLR10
Toll-like receptor 10

1

1

High-throughput

0.536

High

341358

ADA19
Disintegrin and metalloproteinase domain-containing protein 19

1

3

High-throughput

0.536

High

341370

STIM2
Stromal interaction molecule 2

1

1

High-throughput

0.536

High

341373

SUSD2
Sushi domain-containing protein 2

1

1

High-throughput

0.536

High

341376

PLXA1
Plexin-A1

1

2

High-throughput

0.536

High

341377

TSN16
Tetraspanin-16

1

9

High-throughput

0.536

High

341379

JAG2
Protein jagged-2

1

2

High-throughput

0.536

High

341382

ST14
Suppressor of tumorigenicity 14 protein

1

4

High-throughput

0.536

High

247490

FZD6
Frizzled-6

1

0

High-throughput

0.513

High

320851

LRIG2
Leucine-rich repeats and immunoglobulin-like domains protein 2

1

0

High-throughput

0.513

High

327096

NXPH4
Neurexophilin-4

1

0

High-throughput

0.513

High

338674

VNN2
Pantetheine hydrolase VNN2

1

0

High-throughput

0.513

High

341282

PERF
Perforin-1

1

0

High-throughput

0.513

High

341291

SCNNA
Epithelial sodium channel subunit alpha

1

0

High-throughput

0.513

High

341295

ERF
ETS domain-containing transcription factor ERF

1

0

High-throughput

0.513

High

341299

HYAL2
Hyaluronidase-2

1

0

High-throughput

0.513

High

341302

MSLN
Mesothelin

1

0

High-throughput

0.513

High

341303

S39A6
Zinc transporter ZIP6

1

0

High-throughput

0.513

High

341309

MBTP1
Membrane-bound transcription factor site-1 protease

1

0

High-throughput

0.513

High

341311

SGCB
Beta-sarcoglycan

1

0

High-throughput

0.513

High

341320

AGRF1
Adhesion G-protein coupled receptor F1

1

0

High-throughput

0.513

High

341329

HDBP1
Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

1

0

High-throughput

0.513

High

341332

I17RC
Interleukin-17 receptor C

1

0

High-throughput

0.513

High

341339

NLGN2
Neuroligin-2

1

0

High-throughput

0.513

High

341343

EXT2
Exostosin-2

1

0

High-throughput

0.513

High

341345

TTC17
Tetratricopeptide repeat protein 17

1

0

High-throughput

0.513

High

341347

ASTRA
Protein Aster-A

1

0

High-throughput

0.513

High

341360

LMA2L
VIP36-like protein

1

0

High-throughput

0.513

High

341362

DEFM
Peptide deformylase, mitochondrial

1

0

High-throughput

0.513

High

341367

CC50A
Cell cycle control protein 50A

1

0

High-throughput

0.513

High

193659

TPSN
Tapasin

1

1

High-throughput

0.489

High

274421

DNJB6
DnaJ homolog subfamily B member 6

1

1

High-throughput

0.489

High

286515

SG2A1
Mammaglobin-B

1

1

High-throughput

0.489

High

320926

SUN1
SUN domain-containing protein 1

1

1

High-throughput

0.489

High

323945

CSTN1
Calsyntenin-1

1

1

High-throughput

0.489

High

341273

REL1
Prorelaxin H1 [Cleaved into: Relaxin B chain; Relaxin A chain]

1

1

High-throughput

0.489

High

341280

PDIA4
Protein disulfide-isomerase A4

1

3

High-throughput

0.489

High

341297

IDD
Integral membrane protein DGCR2/IDD

1

4

High-throughput

0.489

High

341308

GAS6
Growth arrest-specific protein 6

1

2

High-throughput

0.489

High

341313

CL12B
C-type lectin domain family 12 member B

1

4

High-throughput

0.489

High

341319

TGO1
Transport and Golgi organization protein 1 homolog

1

4

High-throughput

0.489

High

341321

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

3

High-throughput

0.489

High

341324

CREL2
Protein disulfide isomerase CRELD2

1

4

High-throughput

0.489

High

341325

FRMD5
FERM domain-containing protein 5

1

1

High-throughput

0.489

High

341327

CTGE6
cTAGE family member 6

1

3

High-throughput

0.489

High

341328

C1QL4
Complement C1q-like protein 4

1

1

High-throughput

0.489

High

341335

TTC13
Tetratricopeptide repeat protein 13

1

3

High-throughput

0.489

High

341337

CHSTE
Carbohydrate sulfotransferase 14

1

1

High-throughput

0.489

High

341340

DJB14
DnaJ homolog subfamily B member 14

1

3

High-throughput

0.489

High

341341

TM131
Transmembrane protein 131

1

1

High-throughput

0.489

High

341346

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

1

High-throughput

0.489

High

341350

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

5

High-throughput

0.489

High

341352

CSTN3
Calsyntenin-3

1

2

High-throughput

0.489

High

341353

CNPY3
Protein canopy homolog 3

1

1

High-throughput

0.489

High

341361

TOR3A
Torsin-3A

1

1

High-throughput

0.489

High

341364

CHSTC
Carbohydrate sulfotransferase 12

1

1

High-throughput

0.489

High

341371

CHPF2
Chondroitin sulfate glucuronyltransferase

1

1

High-throughput

0.489

High

341374

SUN2
SUN domain-containing protein 2

1

1

High-throughput

0.489

High

341378

CCPG1
Cell cycle progression protein 1

1

1

High-throughput

0.489

High

178128

NPC1
NPC intracellular cholesterol transporter 1

1

1

High-throughput

0.479

High

217670

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

341366

T106B
Transmembrane protein 106B

1

2

High-throughput

0.479

High

341271

DRB1
HLA class II histocompatibility antigen, DRB1 beta chain

1

9

High-throughput

0.445

High

240388

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.437

High

341310

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.437

High

341365

FBX6
F-box only protein 6

1

2

High-throughput

0.437

High

254704

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.426

High

341307

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

341363

SEM4B
Semaphorin-4B

1

0

High-throughput

0.426

High

341351

MIA2
Melanoma inhibitory activity protein 2

1

3

High-throughput

0.407

High

341359

CLPB
Mitochondrial disaggregase

1

2

High-throughput

0.407

High

341317

MPPE1
Metallophosphoesterase 1

2

0

High-throughput

0.328

High

341278

BGLR
Beta-glucuronidase

1

0

High-throughput

0.279

Low

341289

RNAS4
Ribonuclease 4

1

0

High-throughput

0.279

Low

341316

ERFE
Erythroferrone

1

0

High-throughput

0.279

Low

341322

SCAR3
Scavenger receptor class A member 3

1

0

High-throughput

0.279

Low

341323

BTNL3
Butyrophilin-like protein 3

1

0

High-throughput

0.279

Low

341333

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.279

Low

341334

SUMF1
Formylglycine-generating enzyme

1

0

High-throughput

0.279

Low

341336

UXS1
UDP-glucuronic acid decarboxylase 1

1

0

High-throughput

0.279

Low

341338

DIK2A
Divergent protein kinase domain 2A

1

0

High-throughput

0.279

Low

341342

SC65
Endoplasmic reticulum protein SC65

1

0

High-throughput

0.279

Low

341348

ZDH12
Palmitoyltransferase ZDHHC12

1

0

High-throughput

0.279

Low

341354

SPXN
Spexin

1

0

High-throughput

0.279

Low

341357

B3GN4
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 4

1

0

High-throughput

0.279

Low

341368

SELN
Selenoprotein N

1

0

High-throughput

0.279

Low

341369

SENP1
Sentrin-specific protease 1

1

0

High-throughput

0.279

Low

341381

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.279

Low

341318

OCAD2
OCIA domain-containing protein 2

1

0

High-throughput

0.269

Low

322889

UBP19
Ubiquitin carboxyl-terminal hydrolase 19

1

0

Small-scale

0.251

Low

341314

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025